Prevalence of sleep‐related respiratory disorders in 101 schizophrenic inpatients

Abstract

from a sense of incompatibility with wearing PMA or an elevation of muscular tones. Accordingly, we should be cautious about the changes of sleep structure and subjective sleep disturbance when we apply PMA treatment to OSAS patients. Before starting this study, we hypothesized that forward advancement of mandible with PMA night best act to dilate hypopharynx manifested as increase of PAS.3 However, ultrafast MRI of upper airway during sleep showed an improvement not only of GP obstruction, but also of velopharyngeal obstruction in most subjects. Concerning these results, velopharyngeal dilatation brought about by inferior and forward advancement of the mandible manifested as the change of MP-H, N-Me and S N B and the decrease of intraesophageal negative pressure loading was thought to act cooperatively to suppress velopharyngeal collapse. T o a certain extent, elevation of muscle tonus when equipped with PMA might contribute to maintain patency of upper airway. Considering that VP obstruction is most common in OSAS,' PMA treatment niight be widely acceptable for the disorder. AbstractWe studied the prevalence of sleep-related respiratory disorders (SRRD) in 101 schizophrenic inpatients (64 men and 37 women) and in 48 healthy volunteers (control group: 22 men and 26 women) using ambulatory pulseoximetric devices. Those with a desaturation index (DI) 2 5 were classified as having SRRD. The prevalence of S R R D in the schizophrenic patients (men 21.9%, women 13.5%) was not higher than that in the control group (men 30.7%, women 13.6%). Gender difference in the prevalence of S R R D was not observed in schizophrenic group. This was probably because the schizophrenic women took an increased amount of sleeping pills. Neuroleptics were shown to be least effected on SRRD.

Sleep disordered breathing in community psychiatric patients

“…In schizophrenia patients, two studies found no differences in sleep disordered breathing between patient and normal controls 5,28 , however it should be noted that the BMI of patients with schizophrenia was similar to the control subjects in both studies which may cast doubt on how representative these samples were. In contrast an older population (mean age 59 years) studied by Ancoli-Israel 6 showed that 48% of the population had an AHI of > 10 events per hour.…”

“…Sleep disturbance in psychiatric populations may be due to the psychiatric illness, psychotropic medication or the result of a primary sleep disorder. The prevalence of sleep apnoea in the psychiatric population in the community has been studied with conflicting results [5][6][7] .…”

Acute psychosis after CPAP treatment in a schizophrenic patient with sleep apnoea­hypopnoea syndrome

“…ZARCONE and BENSON [7] reported that 14.5% of male patients with schizophrenia had comorbid SAHS. In schizophrenic patients, TAKAHASHI et al [8] in a study based only on oximetric data, reported a sleep-related respiratory disorder prevalence of 21.9% for males and 13.5% for females, not higher than that in a control group.…”

“…Treatment with continuous positive airway pressure (CPAP) has been reported to improve psychological symptoms, psychosocial adjustment, daytime sleepiness [4] and daytime function [5], but it is not clear if CPAP ameliorates the cognitive deficits [6]. Schizophrenia associated to SAHS has rarely been referred [7,8], but, to our knowledge, the induction of a psychotic episode by CPAP treatment in a patient with SAHS and coexisting schizophrenia has never previously been reported.…”

Sleep-Disordered Breathing and Psychiatric Disorders

“…Takahashi and colleagues compared rates of "sleepdisordered breathing" in a sample of 101 Japanese inpatients with DSM-III-R schizophrenia and a group of 48 healthy volunteers (staff, their friends and family) with comparable body mass index (BMI) and age [58]. OSA was diagnosed using ambulatory pulse-oximetry devices and was defined as a RDI>5 (the number of desaturations greater than 4 % below baseline/hour).…”