Prevalence of Small Intestinal Bacterial Overgrowth in Parkinson's Disease

Gabrielli, Maurizio; Bonazzi, Patrizia; Scarpellini, Emidio; Bendia, E.; Lauritano, Ernesto Cristiano; Fasano, Alfonso; Ceravolo, Maria Gabriella; Capecci, Marianna; Bentivoglio, Anna Rita; Provinciali, Leandro; Tonali, P.; Gasbarrini, Antonio

doi:10.1002/mds.23566

Cited by 156 publications

(113 citation statements)

References 15 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…Gastrointestinal dysfunctions, such as constipation and dysphagia, are commonly reported in PD. Gabrielli et al 39 recently showed that small intestinal bacterial overgrowth was highly prevalent in PD. Therefore, decreases in serum catechol sulfate levels in patients with PD may be attributed to abnormal gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

Identification of novel biomarkers for Parkinson's disease by metabolomic technologies

Hatano

Saiki

Okuzumi

et al. 2015

J Neurol Neurosurg Psychiatry

220

179

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Identification of novel biomarkers for Parkinson's disease by metabolomic technologies

Hatano

Saiki

Okuzumi

et al. 2015

J Neurol Neurosurg Psychiatry

220

179

View full text Add to dashboard Cite

show abstract

“…66,67,99,100 The prevalence of SIBO is 25.0-54.5% in PD patients compared to 8.3-20.0% in normal controls. The presence of SIBO has been associated with a greater degree of impairment in motor control in PD with fluctuation in levodopa response.…”

Section: Small Intestinal Bacterial Overgrowthmentioning

confidence: 99%

Gut Microbiota Dysfunction as Reliable Non-invasive Early Diagnostic Biomarkers in the Pathophysiology of Parkinson's Disease: A Critical Review

Nair

Ramachandran

Joghee

et al. 2018

J Neurogastroenterol Motil

119

View full text Add to dashboard Cite

Recent investigations suggest that gut microbiota affects the brain activity through the microbiota-gut-brain axis under both physiological and pathological disease conditions like Parkinson’s disease. Further dopamine synthesis in the brain is induced by dopamine producing enzymes that are controlled by gut microbiota via the microbiota-gut-brain axis. Also alpha synuclein deposition and the associated neurodegeneration in the enteric nervous system that increase intestinal permeability, oxidative stress, and local inflammation, accounts for constipation in Parkinson’s disease patients. The trigger that causes blood brain barrier leakage, immune cell activation and inflammation, and ultimately neuroinflammation in the central nervous system is believed to be due to the chronic low-grade inflammation in the gut. The non-motor symptoms that appear years before motor symptoms could be reliable early biomarkers, if they could be correlated with the established and reliable neuroimaging techniques or behavioral indices. The future directions should therefore, focus on the exploration of newer investigational techniques to identify these reliable early biomarkers and define the specific gut microbes that contribute to the development of Parkinson’s disease. This ultimately should pave the way to safer and novel therapeutic approaches that avoid the complications of the drugs delivered today to the brain of Parkinson’s disease patients.

show abstract

“…Thus, a recent Cochrane review concluded that further studies are required to address the gaps in knowledge regarding the role of HP infection in PD [24], and screening PD patients for HP status has yet to enter routine clinical practice. A role for small intestinal bacterial overgrowth (SIBO) in PD has also been proposed recently [4,5,25]. It is known that SIBO can occur as a sequela of HP infection as well as of gut dysmotility [26].…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori infection is associated with worse severity of Parkinson's disease

Tan

Mahadeva

Marras

et al. 2015

Parkinsonism & Related Disorders

116

View full text Add to dashboard Cite

Prevalence of Small Intestinal Bacterial Overgrowth in Parkinson's Disease

Abstract: Small intestinal bacterial overgrowth is highly prevalent in PD. Gastrointestinal motility abnormalities might explain this association.

Cited by 156 publications

References 15 publications

Identification of novel biomarkers for Parkinson's disease by metabolomic technologies

Identification of novel biomarkers for Parkinson's disease by metabolomic technologies

Gut Microbiota Dysfunction as Reliable Non-invasive Early Diagnostic Biomarkers in the Pathophysiology of Parkinson's Disease: A Critical Review

Helicobacter pylori infection is associated with worse severity of Parkinson's disease

Contact Info

Product

Resources

About