Prevalence of Surgical-Site Infections and Patterns of Antimicrobial Use in a Large Tertiary-Care Hospital in Ho Chi Minh City, Vietnam

Sohn, Annette H.; Parvez, Farah M.; Vu, Tien; Hai, Hoang Hoa; Bích, Nguyễn Ngọc; Thư, Le Thi Anh; Hoa, Le Thi T; Thanh, Nguyễn Hải; Viet, Truong V.; Archibald, Lennox K.; Banerjee, Shailen N.; Jarvis, William R.

doi:10.1086/502070

Cited by 44 publications

(24 citation statements)

References 19 publications

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“…[8][9][10][11][12] Some other workers have found Pseudomonas aeruginosa as the principal offender of SSI. 15,16 In our study gram negative bacilli were more predominant in the classes of wounds other than clean wounds. NNIS system data had revealed that gram positive pathogens were most frequently associated with SSIs.…”

Section: Discussionsupporting

confidence: 47%

“…8 Another study reported a still higher resistance (92%) to gentamicin in gramnegative isolates. 15 In our study the sensitivity pattern to other aminoglycosides was 42.3% sensitivity to amikacin and netilmicin, 53.8% to kanamicin and 57.7% to tobramycin.…”

Section: Antimicrobial Susceptibility Pattern Of Gram Negative Isolatessupporting

confidence: 45%

“…22 Most of the gram negative isolates in our study showed high resistance to quinolones (70%). A still higher resistance of almost 100% to ciprofloxacin was reported in a study by Sohn et al 15 In contrast, another study done in Italy reported only 16.3% -24.8% resistance to Ciprofloxacin over a period of 6 years. 22 In the present study, it was observed that 42-57% of the isolates were sensitive to aminoglycoside group of drugs.…”

Section: Antimicrobial Susceptibility Pattern Of Gram Negative Isolatesmentioning

confidence: 72%

“…This was comparable to a study done in Vietnam, that reported 88% resistance to a third generation cephalosporin. 15 In another study from Italy most isolates were found to be susceptible to ceftriaxone. 22 Most of the gram negative isolates in our study showed high resistance to quinolones (70%).…”

Section: Antimicrobial Susceptibility Pattern Of Gram Negative Isolatesmentioning

confidence: 95%

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Bacteriological profile and antimicrobial susceptibility in surgical site infection in elective abdominal surgeries

et al. 2016

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Section: Discussionsupporting

confidence: 47%

Section: Antimicrobial Susceptibility Pattern Of Gram Negative Isolatessupporting

confidence: 45%

Section: Antimicrobial Susceptibility Pattern Of Gram Negative Isolatesmentioning

confidence: 72%

Section: Antimicrobial Susceptibility Pattern Of Gram Negative Isolatesmentioning

confidence: 95%

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Bacteriological profile and antimicrobial susceptibility in surgical site infection in elective abdominal surgeries

et al. 2016

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“…In our series, the SSI rate in the elective surgery group was found as 10.9% similar to other studies, while in the emergency surgery group, the SSI rate was 26.7%. It is stated in the literature that the SSI rate increases 1.69 times for malignant neoplasms and 1.9-2.65 times for emergency procedures (40). In addition, SSI rate has been shown to increase 1.1-fold with every three-day admission.…”

mentioning

confidence: 98%

An evaluation of treatment results of emergency versus elective surgery in colorectal cancer patients

Bayar

Yılmaz

Akıncı

et al. 2016

UCD

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Objective: Colorectal cancer is still one of the most common causes of cancer related deaths in the world despite improvements in diagnosis and treatment modalities, and application of community-based screening methods. Symptoms of colorectal cancer are non-specific and usually manifest following local progression. A number of patients with advanced stage colorectal cancer present to emergency departments with obstruction as the first sign of disease without any previous symptoms. This presentation is an indication for emergency surgery that has a high rate of morbidity and mortality. In this study, we aimed to determine the factors associated with early diagnosis and survival by comparing postoperative results of colorectal cancer patients who underwent surgery under emergency or elective situation. Material and Methods:Files of colorectal patients treated between 2009-2013 were retrospectively analyzed. Data on patient age, gender, operation type, intraoperative results, length of hospital stay, co-morbidities, postoperative complications and pathological results were evaluated and compared.Results: There was no statistical difference between groups in terms of age, gender, and pathology results (p>0.05). The difference between groups in terms of postoperative length of hospital stay, presence of co-morbid diseases, pathological stage, and postoperative complications was statistically significant (p<0.05). Length of hospital stay, advanced stage on admission, complications such as surgical site infection, evisceration, and anastomosis leakage rates were higher in patients in the emergency surgery group. Conclusion:Risk groups should be determined in order to diagnose colorectal cancer patients at an early stage while they are still asymptomatic, and this information should be incorporated into effective screening programs. This approach will be beneficial to treatment outcomes, complication rates, length of hospital stay, and survival and treatment results. INTRODUCTIONColorectal cancer (CRC) is one of the most frequent cancers with more than one million people worldwide being diagnosed with CRC annually, which is the most common gastrointestinal tract cancer (1). The majority of these neoplasms are endoluminal adenocarcinoma derived from the mucosa, and over 95% of CRC patients benefit from surgery or colonoscopic interventions for premalignant polyps with early diagnosis (2). Despite advances in diagnosis and treatment and dissemination of communitybased screening, colorectal cancer remains to be one of the main reasons of cancer-related deaths in the world (3).

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Letters to the Editor

Bereznicki¹,

Jackson²,

Peterson

et al. 2006

Pharmacy Practice and Res

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LETTERS TO THE EDITOR Ximelagatran cost effectiveness for stroke prevention in atrial fibrillationTo the Editor, In their recent article Valiya et al. concluded that ximelagatran appears to be cost effective in a small group of patients at high risk of bleeding. 1 We believe that this conclusion is not justified based on the findings published in the article. The analysis was based primarily on the results of the open-label SPORTIF III study in which ximelagatran was compared to warfarin for the prevention of thromboembolic stroke associated with atrial fibrillation. 2In this study, both the rate of ischaemic stroke and major bleeding were not significantly different between the anticoagulants. In their analysis, Valiya et al. use a base-case rate of major bleeding of 1.3 events per annum for each drug. We find it baffling that the authors then suggest that ximelagatran would be superior in patients who cannot tolerate warfarin.Ximelagatran has never been studied in patients who have suffered a major bleed or who have other problems while receiving warfarin-these patients were excluded from the trials. Neither head-to-head trial comparing the drugs demonstrated a significant reduction in major bleeding. 2,3Indeed, if the closed-label SPORTIF V trial is given precedence, warfarin was nearly statistically significantly superior at preventing stroke. If the major bleeding rates are similar, it is presumptuous to suggest that ximelagatran would be safer in patients suffering a warfarin-related bleed. Indeed, the authors could have considered the opposite scenario as well. The worstcase major bleeding incidence for warfarin used in the analysis is almost double the rate noted in combined analysis of the SPORTIF trials. 4 The authors did not consider the costs attributable to adverse events associated with ximelagatran, namely monitoring of alanine transaminase (ALT), hepatic failure and cessation of treatment in those with sustained elevations of ALT. This data is available from SPORTIF III, SPORTIF V (published in abstract form in 2004) and the US FDA, published when approval for ximelagatran was not granted because of a lack of safety data and concern about hepatic adverse events. 2,3,5 This data was available prior to submission of the article by Valiya et al. (January 2005). Indeed, AstraZeneca recently removed ximelagatran from the global market due to these safety concerns. Compared to a similar analysis, the cost of each INR test in the Valiya et al. analysis is higher and the cost attributed to a major bleed significantly higher, effectively resulting in a lower estimate of the incremental cost-effectiveness ratio of ximelagatran compared to warfarin. 4 While warfarin is not a perfect drug, there is scope to improve its management. In one analysis of major bleeding in the elderly, 17 of 18 events were considered preventable by either avoiding overanticoagulation, or drugs that added to the bleeding risk. 6 We believe the following should have been the primary conclusion of the analysis: ximelagat...

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Prevalence of Surgical-Site Infections and Patterns of Antimicrobial Use in a Large Tertiary-Care Hospital in Ho Chi Minh City, Vietnam

Cited by 44 publications

References 19 publications

Bacteriological profile and antimicrobial susceptibility in surgical site infection in elective abdominal surgeries

Bacteriological profile and antimicrobial susceptibility in surgical site infection in elective abdominal surgeries

An evaluation of treatment results of emergency versus elective surgery in colorectal cancer patients

Letters to the Editor

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