Prevalence of syphilis among voluntary blood donors in Liguria region (Italy) from 2009 to 2013

Drago, Francesco; Cogorno, Ludovica; Ciccarese, Giulia; Strada, P.; Tognoni, Massimo; Rebora, Alfredo; Parodi, Aurora

doi:10.1016/j.ijid.2014.04.008

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…The TTIs studied in this study showed higher prevalence compared with many other studies. Our study findings showed a higher prevalence of HIV when compared with other studies, including 0.12% in Nepal [15], 0.005% in Italy [17], 0.03% in China [18], 0.12% in Pakistan [19], 0.074% in India [16]. In addition, syphilis had higher prevalence when compared with studies done in India (0.09%) [20], in Nepal (0.48%) [15], Italy (0.031%) [17], Pakistan (0.07%) [19].…”

Section: Discussioncontrasting

confidence: 60%

The prevalence of transfusion transmitted infections: A focus on hepatitis B virus among blood donors at Hawassa blood bank center, Southern Ethiopia

Bonja¹,

Hussein²,

Alemu³

et al. 2017

Int J Blood Transfus Immunohematol

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Aims: Millions of lives are saved each year through blood transfusion but a safe blood supply is a critical component of health care to prevent the spread of blood-borne infectious diseases. Therefore, it is essential to assess the prevalence and identify the most common culprit and risk in transfusion services. Methods A cross-sectional study was conducted from April 2015 to May 2015 at the Hawassa blood bank center. Blood donors who donated blood for transfusion purposes were considered for the study. Whole blood was collected and serum was separated from each donor. The sera were used for examination of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), and syphilis. Thick film was prepared and stained using Giemsa for malaria detection. Results: A total of 384 blood donors were screened during the study period. Among these donors, 67.2% (258) were males and 32.8% (126) were females. The overall prevalence of transfusion transmitted infections (TTI) was 28 out of 384 (7.29%) apparently healthy donors. and malaria was 6 (1.6%), 16 (4.2%), 2 (0.5%), 3 (0.8%) and 1 (0.3%) respectively. Two out of 384 (0.5%) had co-infections with HIV-HBV 1 (0.26%) and HBV-HCV 1 (0.26%). A 1:14 ratio (7.14%) of the blood collected was discarded only due to the presence of TTI. The highest discard rate was recorded from HBV infected units 57.1%, followed by HIV 21.40%, syphilis 10.7%, HCV 7.10%, and malaria 3.60%. Overall, TTIs were found in males (7.8%), married (2.5%), rural (8%), private/NGO employed donors (28.6%), 45-54 age group (20%), and in replacement/family donors (16.1%) (p = 0.039). Conclusion: The prevalence of TTIs in the Hawassa blood bank center was significantly high. HBV infection was the major cause for TTIs. Recommendations: Overall, effective clinical and laboratory screening of blood donors is essential. Proper treatment of TTI positive cases and a good donor selection program will help to reduce the prevalence of TTIs in donor units. Blood bank programs should give much more consideration in screening and diagnosis of HBV which is the main TTI that causes a high discard rate of blood.

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Section: Discussioncontrasting

confidence: 60%

The prevalence of transfusion transmitted infections: A focus on hepatitis B virus among blood donors at Hawassa blood bank center, Southern Ethiopia

Bonja¹,

Hussein²,

Alemu³

et al. 2017

Int J Blood Transfus Immunohematol

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“…50 Studies from several African countries have observed a high prevalence, for instance, Burkina Faso (1.5%), 51 Nigeria, (3.1%), 22 and Angola (20.0%) 52 while data from developed countries indicate a low prevalence comparatively, Qatar (0.43), 26 Iran (0%), 37 United States of America (0.16%), 53 and Italy (0.031%). 54 The malaria positivity in the present study was 0.14%. Earlier studies from Pakistan have reported a comparatively similar results of 0.1 6 and 0.10%.…”

Section: Discussionsupporting

confidence: 41%

Seroprevalence of Transfusion-Transmitted Infections among Voluntary and Replacement Blood Donors at the Peshawar Regional Blood Centre, Khyber Pakhtunkhwa, Pakistan

et al. 2021

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Introduction Blood transfusion is linked to several risks, most notably the transmission of transfusion-transmitted infections (TTIs), including hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), syphilis, and malaria. The risk posed by these blood-borne infectious agents is high in developing countries, including Pakistan. This fact stresses the need for regular surveillance of TTIs. Therefore, the present study was undertaken to assess the seroprevalence of TTIs at a regional blood center. Material and Methods This was a retrospective 4-year descriptive study undertaken at the Regional Blood Centre in Peshawar, Khyber Pakhtunkhwa Province of Pakistan, on the blood donor data from June 2016 to May 2020. A total of 41,817 donors donated blood during the study period and were screened for HBV, HCV, HIV, syphilis, and malaria. To ensure donor privacy, donors were identified via codes and no personal information was available. The data were extracted from the ZAAVIA blood transfusion information system database. Results The study included a total of 41,817 donors—41,493 (99.22%) males and 324 (0.78%) females. Of them, 22,343 (53.43%) were voluntary donors while 19,474 (46.57%) were replacement donors. An overall TTI prevalence rate of 4.61% was found. The TTI prevalence rate in voluntary donors was 3.90% while 5.42% in replacement donors. The overall prevalence of HBV, HCV, HIV, syphilis, and malaria was 1.95, 1.38, 0.23, 0.91, and 0.14%, respectively. Conclusion The current study documented a high prevalence (1,929 out of 41,817, 4.61%) of TTIs, especially in replacement donors (1,057 out of 19,474, 5.42%), and low participation of female donors. The recommendations include the promotion of voluntary blood donors, enrolment of female blood donors, and screening of donated blood through highly sensitive screening assay (i.e., nucleic acid testing).

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“…The reactive cases of syphilis (T. pallidum) in the present study were 272 (0.83%). The findings in our study were higher when compared with the results of different studies conducted in some developed countries, including the USA (0.16%) [50], Italy (0.031%) [51], Israel (0.047%) [52], and Saudi Arabia (0.044%) [53]. When comparing our results with studies from various African countries, the prevalence of syphilis in blood donors was much higher than the results of the present study, for example, in Burkina Faso (1.5%) [54], Nigeria (3.1%) [55], and Angola (20.0%) [56].…”

Section: Plos Onecontrasting

confidence: 88%

Analysis of molecular subtypes and antibiotic resistance in Treponema pallidum isolates from blood donors in Khyber Pakhtunkhwa, Pakistan

Muhammad,

Khalifa,

Salih

et al. 2024

PLoS ONE

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Syphilis, caused by Treponema pallidum, is resurging globally. Molecular typing allows for the investigation of its epidemiology. In Pakistan and other nations, T. pallidum subsp. pallidum has developed widespread macrolide resistance in the past decade. A study at the Peshawar Regional Blood Centre from June 2020–June 2021 analyzed serum samples from 32,812 blood donors in Khyber Pakhtunkhwa, Pakistan, to assess circulating T. pallidum strains and antibiotic resistance. Blood samples were initially screened for T. pallidum antibodies using a chemiluminescent microparticle immunoassay (CMIA). CMIA-reactive samples underwent polymerase chain reaction (PCR) targeted the polA, tpp47, bmp, and tp0319 genes. PCR-positive samples were further analyzed for molecular subtyping using a CDC-developed procedure and tp0548 gene examination. All PCR-positive samples were analyzed for the presence of point mutations A2058G and A2059G in 23S rRNA, as well as the G1058C mutation in 16S rRNA. These mutations are known to impart antimicrobial resistance to macrolides and doxycycline, respectively. Out of 32,812 serum samples, 272 (0.83%) were CMIA-reactive, with 46 being PCR-positive. Nine T. pallidum subtypes were identified, predominantly 14d/f. The A2058G mutation in 23S rRNA was found in 78% of cases, while G1058C in 16S rRNA and A2059G in 23S rRNA were absent. The research found donor blood useful for assessing T. pallidum molecular subtypes and antibiotic resistance, especially when chancres are not present. The prevalent subtype was 14d/f (51.85%), and the high macrolide resistance of 36 (78%) indicates caution in using macrolides for syphilis treatment in Khyber Pakhtunkhwa, Pakistan.

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Prevalence of syphilis among voluntary blood donors in Liguria region (Italy) from 2009 to 2013

Cited by 6 publications

References 6 publications

The prevalence of transfusion transmitted infections: A focus on hepatitis B virus among blood donors at Hawassa blood bank center, Southern Ethiopia

The prevalence of transfusion transmitted infections: A focus on hepatitis B virus among blood donors at Hawassa blood bank center, Southern Ethiopia

Seroprevalence of Transfusion-Transmitted Infections among Voluntary and Replacement Blood Donors at the Peshawar Regional Blood Centre, Khyber Pakhtunkhwa, Pakistan

Analysis of molecular subtypes and antibiotic resistance in Treponema pallidum isolates from blood donors in Khyber Pakhtunkhwa, Pakistan

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