Prevalence of the Leptospira serovars bratislava, grippotyphosa, mozdok and pomona in French dogs

Renaud, Claire; Andrews, SJ; Djelouadji, Zouheira; Lecheval, Sandrine; Corrao-Revol, Nadine; Buff, Samuel; Demont, Pierre; Kodjo, Angéli

doi:10.1016/j.tvjl.2012.10.002

Cited by 35 publications

(35 citation statements)

References 6 publications

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“…Although serovar Mozdok has been implicated in canine leptospirosis, mainly in Europe, 10 to our knowledge, this is the first report of its isolation. Similarly, this is the first isolate from a patient in the southern hemisphere and only the second worldwide.…”

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confidence: 78%

“…Human leptospirosis caused by serogroup Pomona is common in that region and while serovar Mozdok has not been implicated in any human cases, 9 it is a causative agent of canine leptospirosis in Europe. 10 We report the isolation and characterization of two isolates of serovar Mozdok recovered from cases of canine and human leptospirosis in Pelotas, southern Brazil. The canine strain was isolated in 2009 during a municipal dog neutering campaign.…”

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confidence: 99%

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Infection with Leptospira kirschneri Serovar Mozdok: First Report from the Southern Hemisphere

Cunha¹,

Félix²,

Neto³

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Leptospirosis is a global zoonosis caused by pathogenic Leptospira spp. In this study, we characterized two Leptospira kirschneri serogroup Pomona serovar Mozdok isolates, one obtained from a dog and the other from a patient with severe leptospirosis, 4 years later. Histopathological analysis showed that both isolates caused severe tissue damage when used to infect hamsters. While L. kirschneri serogroup Pomona serovar Mozdok is endemic in animals in Europe, there is only one report of human leptospirosis in the literature. Although strains belonging to L. kirschneri serogroup Pomona have been identified in cases of human leptospirosis in Europe, serovar Mozdok has not yet been implicated. The 4-year interval between isolations and the fact that this is the first report of serovar Mozdok as the causative agent of human leptospirosis in the southern hemisphere, demonstrates its epidemiological importance to public health. Moreover, the presence of serovar Mozdok in Brazil has the potential to affect vaccine and diagnostic test development.

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confidence: 78%

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confidence: 99%

Infection with Leptospira kirschneri Serovar Mozdok: First Report from the Southern Hemisphere

Cunha¹,

Félix²,

Neto³

et al. 2016

The American Society of Tropical Medicine and Hygiene

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“…An MST database was created from spacer sequences obtained for Leptospira sp. strains belonging to the Icterohaemorrhagiae, Australis, Grippotyphosa, and Canicola serogroups (Table 2), which are highly prevalent in France, with the seroprevalence of the Icterohaemorrhagiae serogroup in rodents being as high as 45.6% (12,(27)(28)(29)(30). The choice of spacer was based on the same MLST scheme (21).…”

Section: Discussionmentioning

confidence: 99%

“…During the serological diagnosis, the identification permits the establishment of the serogroup responsible for the infection. Moreover, the serogroup identification enables the determination of the animal reservoir and the prevalence of serogroup according to geographic regions (4), which can then be used to plan updates to the vaccine components (11,12).…”

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confidence: 99%

“…Moreover, MST permitted the phylogeographical lineages to be defined (26), which is of great interest in epidemiologic studies. In this study, we investigated the MST for L. interrogans species genotyping, particularly for the Icterohaemorrhagiae, Canicola, Australis, and Grippotyphosa serogroups, which are the most prevalent serogroups in France (12,(27)(28)(29)(30). The results of MST genotyping have been subsequently compared with the results of the VNTR analysis used as the reference molecular typing method.…”

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High-Resolution Typing of Leptospira interrogans Strains by Multispacer Sequence Typing

et al. 2014

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Leptospirosis is a worldwide zoonosis which is responsible for the typical form of Weil's disease. The epidemiological surveillance of the Leptospira species agent is important for host prevalence control. Although the genotyping methods have progressed, the identification of some serovars remains ambiguous. We investigated the multispacer sequence typing (MST) method for genotyping strains belonging to the species Leptospira interrogans, which is the main agent of leptospirosis worldwide. A total of 33 DNA samples isolated from the reference strains of L. interrogans serogroups Icterohaemorrhagiae, Australis, Canicola, and Grippotyphosa, which are the most prevalent serogroups in France, were analyzed by both the variable-number tandem-repeat (VNTR) and MST methods. An MST database has been constructed from the DNA of these reference strains to define the MST profiles. The MST profiles corroborated with the VNTR results. Moreover, the MST analysis allowed the identification at the serovar level or potentially to the isolate level for strains belonging to L. interrogans serovar Icterohaemorrhagiae, which then results in a higher resolution than VNTR (Hunter-Gaston index of 0.94 versus 0.68). Regarding L. interrogans serogroups Australis, Canicola, and Grippotyphosa, the MST and VNTR methods similarly identified the genotype. The MST method enabled the acquisition of simple and robust results that were based on the nucleotide sequences. The MST identified clinical isolates in correlation with the reference serovar profiles, thus permitting an epidemiological surveillance of circulating L. interrogans strains, especially for the Icterohaemorrhagiae serogroup, which includes the most prevalent strains of public health interest.

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Leptospira and Leptospirosis

Faine¹

2015

Current Topics in Microbiology and Immunology

152

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Prevalence of the Leptospira serovars bratislava, grippotyphosa, mozdok and pomona in French dogs

Cited by 35 publications

References 6 publications

Infection with Leptospira kirschneri Serovar Mozdok: First Report from the Southern Hemisphere

Infection with Leptospira kirschneri Serovar Mozdok: First Report from the Southern Hemisphere

High-Resolution Typing of Leptospira interrogans Strains by Multispacer Sequence Typing

Leptospira and Leptospirosis

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