Prevalence of thrombocytopenia during pregnancy, and its effect on pregnancy and perinatal outcome

Chandil, Nidhi; Luthra, Sonia; Dwivedi, AD; Singh, Ankita

doi:10.33545/gynae.2020.v4.i2a.503

Cited by 4 publications

(11 citation statements)

References 3 publications

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“…Thrombocytopenia is a substantial hematological abnormality among pregnant women, affecting approximately 7–11% of pregnant women around the world. 1 , 2 Developing countries share a huge burden of thrombocytopenia. A study revealed 8.4% of the overall global burden of thrombocytopenia among pregnant women; with the highest burden reported from Africa (15.3%) and the lowest from Taiwan.…”

Section: Introductionmentioning

confidence: 99%

“…Thrombocytopenia is a common problem during pregnancy and is associated with several negative consequences such as excessive bleeding during or after childbirth, maternal and fetal complications, 10 , 13 which may result in significant morbidity and mortality for both mother and fetus. 3 , 14 Several epidemiological studies reported 19%, 15.8%, and 8.8–10.5% burden of thrombocytopenia among pregnant women in Libya, 9 Uganda, 15 and India, 2 , 16 , 17 respectively. Furthermore, the risk of bleeding was significantly higher among severe thrombocytopenic women, 15 , 18 which requires appropriate monitoring and management.…”

Section: Introductionmentioning

confidence: 99%

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Thrombocytopenia Among Pregnant Women in Southwest Ethiopia: Burden, Severity, and Predictors

Haile¹,

Kebede²,

Abera³

et al. 2022

JBM

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Background Thrombocytopenia is a worldwide public health problem in pregnant women and is associated with significant maternal–fetal complications and mortality. Determination of burden, severity, and predictors of thrombocytopenia in pregnant women is imperative to develop intervention measures to mitigate their risk and public health impact, which is not well known in Ethiopia, particularly in the selected study area. Thus, this study aimed to determine the burden, severity, and predictors of thrombocytopenia among pregnant women in Wolkite University Specialized Hospital, southwest Ethiopia. Materials and Methods A cross-sectional study was employed among 422 pregnant women from May to August 2021. A structured questionnaire was used to collect data on socio-demographic, reproductive, and related characteristics. Venous blood samples were collected and platelet counts were determined by Sysmex XP-300 hematology analyzer. A binary logistic regression analysis was performed using SPSS version 22 software to identify independent predictors of thrombocytopenia. The p-value <0.05 was considered statistically significant. Results The overall burden of thrombocytopenia among pregnant women was 14.5% (95% CI: 11.4–17.8). Among them, 77%, 16.4%, and 6.6% had mild, moderate, and severe thrombocytopenia, respectively. Rural residence (AOR: 2.9, 95% CI: 1.5–5.8), increasing age (AOR: 1.9, 95% CI: 1.04–3.44), alcohol consumption (AOR: 2.48, 95% CI: 1.3–4.5), and HIV infection (AOR: 8.5, 95% CI: 1.9–18.4) were independent predictors of thrombocytopenia among the pregnant women. Conclusion A high burden of thrombocytopenia (14.5%) was observed among the pregnant women in this study area. Rural residence, increasing age, consumption of alcohol, and HIV infection were identified as independent predictors of thrombocytopenia. The findings of this study should be taken into consideration to conduct appropriate intervention measures on identified predictors and implement routine screening of platelet count, thrombocytopenia diagnosis, and treatments to reduce the burden of morbidity and mortality among pregnant women.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thrombocytopenia Among Pregnant Women in Southwest Ethiopia: Burden, Severity, and Predictors

Haile¹,

Kebede²,

Abera³

et al. 2022

JBM

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“…Platelet count was done in the central square of the Neubauer chamber (1 central and four corner squares) and calculated by using the following formula. 14 Platelet count per liter=No of cells counted x dilution x 10 6 /Volume counted (ml).…”

Section: Methodsmentioning

confidence: 99%

Thrombocytopenia in Pregnancy: A Cross-Sectional Study in Northern Pakistan

Ellahi

Khan

Shahid

et al. 2022

PAFMJ

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Objective: To determine the association of thrombocytopenia (mild, moderate & severe) with pregnancy-related disorders. Study Design: Cross-sectional study. Place and Duration of Study: Department of Haematology of Pakistan Railway Hospital, Rawalpindi Pakistan, in collaboration with the Departments of Obstetrics and Gynecology of Pak Emirates Military Hospital and Fuji Foundation Hospital, Rawalpindi Pakistan, from Oct 2018 to Oct 2019. Methodology: Seventy-five pregnant females with platelet count <150x109/l were included. Blood samples were taken and analyzed for complete blood count, peripheral blood smear, manual count by Neubauer chamber, uric acid, urinary proteins, liver function tests (bilirubin & aspartate aminotransferase), lactate dehydrogenase, coagulation profile and viral serology (Hepatitis B & C). Results: Out of a total of 75 thrombocytopenic pregnant females, gestational thrombocytopenia was most common (74.7%), followed by preeclampsia (17.3%), HELLP syndrome (4%), immune thrombocytopenic purpura (4%) respectively. Mild thrombocytopenia was frequently observed in patients of G.T. (62.5%), while moderate thrombocytopenia (84.6%) was generally detected in preeclampsia patients. Severe thrombocytopenia was mostly identified in patients with HELLP syndrome (66.7%) and immune thrombocytopenic purpura (66.7%). Conclusion: Mild thrombocytopenia is mostly presented in gestational thrombocytopenia. Moderate thrombocytopenia was frequent in patients with preeclampsia, and severe thrombocytopenia was usually diagnosed in patients with HELLP syndrome and immune thrombocytopenic purpura, which require apposite and judicious management for the safety of mother and fetus.

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“…Platelet counts of less than 100,000 per millilitre (ml), between 50,000 and 100,000 ml (ml), and less than 50,000 ml (ml) are considered mild, moderate, and severe, respectively, according to [3] research. [4] Approximately 7-11% of pregnant women throughout the world experience thrombocytopenia [5,6], making it a significant haematological disorder. Thrombocytopenia is disproportionately prevalent in low-income regions.…”

Section: Introductionmentioning

confidence: 99%

“…[11] Multiple epidemiological studies found that thrombocytopenia was a major problem among pregnant women in Libya [12] (19%), Uganda [13] (15.8%), and India (8.8-10.5%). [6,14,15] The prevalence of thrombocytopenia during pregnancy is notably different in our demographic, and this study helps to determine the extent to which it is inadequately diagnosed and mismanaged in pregnant women. Obstetricians can benefit from the magnitude that has been documented.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Thrombocytopenia in Pregnant Females

Qurban¹,

Arshad²,

Hussain³

et al. 2022

PJMHS

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Objective: This study was aimed to assess the frequency of thrombocytopenia in pregnant females. Study design: Descriptive cross-sectional study Place and duration of study: Rashid Latif Medical College, Lahore, From November, 2021 to April, 2022. Methods: A total of 380 pregnant females were enrolled to examine. Blood samples from pregnant women were taken to measure the platelet counts by using hematology analyzer. For statistical significance, proportions were analyzed with the Chi square. Detailed socio-demographics of enrolled cases included age, residence, occupational status, educational status, reproductive and related characteristics and BMI were recorded after taking informed written consent. SPSS-21was used to analyze the data. Results: In this study, 380 pregnant females were included with mean age 28.1years. Majority of the females 228/380 (60%) had rural residence, 160 (42.1%) were in third trimester of their pregnancy. Frequency of thrombocytopenia was recorded in 40 pregnant females as 10.5%. Females in their third trimester had moderate thrombocytopenia of about 81.0%, in second trimester 76.0% and in first trimester 74.0% respectively. Conclusion: Thrombocytopenia is a frequent complication of pregnancy. In the third trimester of pregnancy, thrombocytopenia was shown to affect a disproportionately high number of the women. Most patients are asymptomatic, hence it is important to assess for it by checking the peripheral smear and platelet count often throughout pregnancy, especially in the third trimester. Keywords: Thrombocytopenia, pregnant females, third trimester.

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Prevalence of thrombocytopenia during pregnancy, and its effect on pregnancy and perinatal outcome

Cited by 4 publications

References 3 publications

Thrombocytopenia Among Pregnant Women in Southwest Ethiopia: Burden, Severity, and Predictors

Thrombocytopenia Among Pregnant Women in Southwest Ethiopia: Burden, Severity, and Predictors

Thrombocytopenia in Pregnancy: A Cross-Sectional Study in Northern Pakistan

Frequency of Thrombocytopenia in Pregnant Females

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