Prevalence of thyroid dysfunction and thyroid autoimmunity in polycystic ovary syndrome: A multicenter study from Bangladesh

Kamrul-Hasan, A B; Aalpona, Fatema Tuz Zahura; Mustari, Marufa; Akter, Farhana; Chanda, P K; Rahman, Mohammad Motiur; Mahbub, Mohammad Imtiaj; Selim, Shahjada

doi:10.4103/trp.trp_6_20

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…In an Indian study, Lakshminarayana and collaborators (2016) reported that 84.31% patients were euthyroid while 1.6%, 7.15%, 2.77% and 4.17% patients had subclinical hyperthyroidism, subclinical hypothyroidism, hyperthyroidism and hypothyroidism, respectively 19 . A study performed in Bangladesh by Kamrul-Hasan and partners (2020) highlighted that thyroid dysfunction prevalence was 17% (11% subclinical and 5.2% overt hypothyroidism while 0.4% subclinical and 0.4% overt hyperthyroidism) 20 . Another study performed in China by Huang and colleagues (2020) confirmed that \ overall thyroid diseases prevalence among population was only 8.81% (overt hyperthyroidism 0.38%, subclinical hyperthyroidism 1.86%, overt hypothyroidism 0.70% and subclinical hypothyroidism 5.87% 21 .…”

Section: Discussionmentioning

confidence: 99%

Incidence of Thyroid Diseases in Local Population

Javed¹

2023

PJMHS

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Background: Thyroid diseases are considered most significant public health dilemma worldwide with global prevalence of 5%-10%. In Pakistan, the hypothyroidism and hyperthyroidism prevalence is 4.1% and 5.1%, respectively. Thyroid disorder is a common, identifiable and simply curable, but if not diagnosed or left untreated can have intense adverse effects. Aim: To evaluate the incidence of thyroid diseases in local population of Lahore. Study design: Cross-sectional study. Methods: It is carried out among patients visiting Arif Memorial Teaching Hospital, Lahore. A total of 257 patients aged between 18 to 65 years with clinical features suggestive of thyroid disorders from October 2021 to November 2022 were included. Patients data were collected through questionnaire and analyzed using SPSS version 25.0. Results: Among 257 respondents, 64.2% were females and the mean age was 41.93±11.522 years. 33.9% respondents had family history of thyroid, 23.8% diagnosed with hypothyroidism, 12.8% with hyperthyroidism and 35.4% with subclinical hypothyroidism while 28% respondents were euthyroid. The association between thyroid disease and age was found statistically significant (P=0.000) but insignificant (P=0.351) between thyroid disease and gender. Conclusion: Study concluded that incidence of thyroid diseases was 72% in study population. Keywords: Incidence, thyroid disease, hypothyroidism, hyperthyroidism, euthyroidism.

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Section: Discussionmentioning

confidence: 99%

Incidence of Thyroid Diseases in Local Population

Javed¹

2023

PJMHS

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“…For example, two studies investigating clinical practice patterns in the management of primary hypothyroidism ( 12 ) and Graves’ disease ( 13 ) demonstrated both alignment and focal divergence from the available clinical practice guidelines. Despite having a high burden of patients suffering from thyroid disorders in Bangladesh ( 3 , 14 , 15 ), there is hardly any study investigating the practice pattern of physicians for management of these disorders. Moreover, following the appropriate guideline for all the time in a resource poor setting like Bangladesh is not always feasible.…”

Section: Introductionmentioning

confidence: 99%

Approach to management of hypo and hyperthyroidism in Bangladesh: a nationwide physicians’ perspective survey

Selim,

Mustari,

Khan

et al. 2024

Front. Endocrinol.

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IntroductionThyroid disorders are common clinical conditions globally. The objective of the present study was to evaluate the physicians’ approach to the diagnosis and treatment of thyroid disorders in Bangladesh.MethodsThe present nationally representative cross-sectional study was conducted among 662 physicians of different levels (general practitioners as well as specialists) from different hospitals in Bangladesh from January to June 2023. A self-administered semi-structured questionnaire including information about demographics and practice patterns for the diagnosis and management of thyroid disorders was used for data collection. Descriptive statistics were used to analyze the data.ResultsThe American Thyroid Association (ATA) guidelines were the most commonly followed guidelines for the diagnosis and management of thyroid disorders (60%), followed by the American Association of Clinical Endocrinologists (AACE) guidelines (18%) and the European Thyroid Association (ETA) guidelines (9%). Serum TSH, free T3 and free T4 levels were the most frequently used diagnostic tests for the evaluation and follow-ups of both hypothyroid and hyperthyroid states in adults, pregnant women and children, followed by total T3 and total T4 levels. Other tests, such as anti-TPO antibody, anti-TG antibody, anti-TPO, ultrasound scan of the thyroid gland, etc., were rarely used by the participating physicians. Levothyroxine at a dose of 25 to 50 mcg and carbimazole at a dose of 30 to 45 mg were the most frequently used drugs for hypothyroid and hyperthyroid patients, respectively. Almost 65% of the physicians suggested routine thyroid function tests before surgery. In addition, more than 90% of the physicians agreed that thyroid screening for pregnancy, neonates, school children and adults would be mandatory.ConclusionThe majority of the physicians participating in our study followed relevant guidelines for the diagnosis and management of thyroid disorders in Bangladesh. However, there are still some gaps to be improved, as a good number of physicians did not follow specific guidelines for these disorders.

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A Review of Autoimmune Thyroid Diseases and Their Complex Interplay with Female Fertility

Carafone,

Knutson,

Gigliotti

2024

Semin Reprod Med

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Hashimoto thyroiditis and Graves' disease are autoimmune thyroid disorders that are common in women of reproductive age and have a complex relationship with female fertility and health of the maternal–fetal dyad. Both hyperthyroidism and hypothyroidism, whether subclinical or overt in severity, directly or indirectly affect nearly every level of the hypothalamic–pituitary–ovary axis, uterine and ovarian function, as well as fetal development from implantation through delivery. Autoimmunity itself also appears to negatively impact both spontaneous and assisted fertility, as well as miscarriage risk, although the mechanism remains unclear, and the presence and magnitude of risk is variable in published literature. While treatment of overt hyperthyroidism and hypothyroidism is unequivocally recommended by professional societies, the impact of treatment on fertility outcomes, and the role of treatment in subclinical thyroid disease is more controversial. Unfortunately, levothyroxine has not been shown to abrogate the risk of subfertility and miscarriage observed in euthyroid thyroid autoantibody positive women.

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Prevalence of thyroid dysfunction and thyroid autoimmunity in polycystic ovary syndrome: A multicenter study from Bangladesh

Cited by 5 publications

References 20 publications

Incidence of Thyroid Diseases in Local Population

Incidence of Thyroid Diseases in Local Population

Approach to management of hypo and hyperthyroidism in Bangladesh: a nationwide physicians’ perspective survey

A Review of Autoimmune Thyroid Diseases and Their Complex Interplay with Female Fertility

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