Prevalence of Thyroid Incidentalomas from 1995 to 2016: A Single-Center, Retrospective Cohort Study

Drake, Tyler; Gravely, Amy; Westanmo, Anders; Billington, Charles J.

doi:10.1210/jendso/bvz027

Cited by 21 publications

(14 citation statements)

References 13 publications

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“…This modality was also found to have the highest rate of detection of incidental thyroid nodules in a single institutional study by Drake and colleagues and were reported more frequently in the past decade. 20 Other studies have found ultrasonography examinations to report incidental thyroid disease with the highest frequency at 20% to 67% of patients, 21,22 but this is likely because of differing approaches to classification of detection modes. We sought to identify the upstream test that prompted the use of ultrasonography to examine the nodule.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Rising Incidence of Thyroid Cancer and Thyroid Nodule Detection Modes

Sajisevi

Caulley

Eskander

et al. 2022

JAMA Otolaryngol Head Neck Surg

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IMPORTANCEThere is epidemiologic evidence that the increasing incidence of thyroid cancer is associated with subclinical disease detection. Evidence for a true increase in thyroid cancer incidence has also been identified. However, a true increase in disease would likely be heralded by an increased incidence of thyroid-referable symptoms in patients presenting with disease.OBJECTIVES To evaluate whether modes of detection (MODs) used to identify thyroid nodules for surgical removal have changed compared with historic data and to determine if MODs vary by geographic location. DESIGN, SETTING, AND PARTICIPANTSThis was a retrospective analysis of pathology and medical records of 1328 patients who underwent thyroid-directed surgery in 16 centers in 4 countries: 4 centers in Canada, 1 in Denmark, 1 in South Africa, and 12 in the US. The participants were the first 100 patients (or the largest number available) at each center who had thyroid surgery in 2019. The MOD of the thyroid finding that required surgery was classified using an updated version of a previously validated tool as endocrine condition, symptomatic thyroid, surveillance, or without thyroid-referable symptoms (asymptomatic). If asymptomatic, the MOD was further classified as clinician screening examination, patient-requested screening, radiologic serendipity, or diagnostic cascade. MAIN OUTCOMES AND MEASURESThe MOD of thyroid nodules that were surgically removed, by geographic variation; and the proportion and size of thyroid cancers discovered in patients without thyroid-referable symptoms compared with symptomatic detection. Data analyses were performed from April 2021 to February 2022. RESULTSOf the 1328 patients (mean [SD] age, 52 [15] years; 993 [75%] women; race/ethnicity data were not collected) who underwent thyroid surgery that met inclusion criteria, 34% (448) of the surgeries were for patients with thyroid-related symptoms, 41% (542) for thyroid findings discovered without thyroid-referable symptoms, 14% (184) for endocrine conditions, and 12% (154) for nodules with original MOD unknown (under surveillance). Cancer was detected in 613 (46%) patients; of these, 30% (183 patients) were symptomatic and 51% (310 patients) had no thyroid-referable symptoms. The mean (SD) size of the cancers identified in the symptomatic group was 3.2 (2.1) cm (median [range] cm, 2.6 [0.2-10.5]; 95% CI, 2.91-3.52) and in the asymptomatic group, 2.1 (1.4) cm (median [range] cm, 1.7 [0.05-8.8]; 95% CI, 1.92-2.23). The MOD patterns were significantly different among all participating countries.CONCLUSIONS AND RELEVANCE This retrospective analysis found that most thyroid cancers were discovered in patients who had no thyroid-referable symptoms; on average, these cancers were smaller than symptomatic thyroid cancers. Still, some asymptomatic cancers were large, consistent with historic data. The substantial difference in MOD patterns among the 4 countries suggests extensive variations in practice.

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Section: Discussionmentioning

confidence: 99%

Evaluating the Rising Incidence of Thyroid Cancer and Thyroid Nodule Detection Modes

Sajisevi

Caulley

Eskander

et al. 2022

JAMA Otolaryngol Head Neck Surg

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“…Also, there are differing guidelines on the size cutoff for thyroid nodule FNAs (10,11), and adopting less aggressive size criteria would reduce overdiagnosis. Finally, addressing the increasing prevalence of incidental thyroid nodules (12) and how this impacts overdiagnosis and overtreatment is important.…”

Section: Commentarymentioning

confidence: 99%

Should Small Low-Risk Papillary Thyroid Cancer Be Called Cancer at All?

Drake¹

2021

Clinical Thyroidology

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“…The increased use of different imaging modalities, such as ultrasound, computed tomography and magnetic resonance imaging have shown a steady increase in the prevalence of thyroid incidentaloma. In a contrast-enhanced MR angiography study, incidental thyroid nodules were detected in 4.6% of patients 11,12 .…”

Section: Introductionmentioning

confidence: 99%

Incidental Detection of Thyroid Nodule on Carotid Color Doppler Ultrasound in Patients Presenting with Cerebrovascular Diseases

2022

PJMD

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Background: Thyroid nodules are often detected in clinical practice, during physical examination, or accidentally during different imaging techniques. Most of these nodules are characterized as benign, and thyroid cancer is identified in only a small subclass. Ultrasonography is considered an important tool in thyroid nodule evaluation. Therefore, the study aimed to determine the frequency of incidental detection of a nodule of thyroid on carotid color Doppler ultrasound in patients presenting with cerebrovascular diseases. Methods: A cross-sectional descriptive study was carried out in the PNS Shifa hospital, Radiology department, from August 2017 to May 2018. Patients (n=110) underwent Color Doppler Ultrasound examinations with a scanner (Xario), furnished with a linear transducer operational at 10 MHz by the researcher. Incidental detection of thyroid nodule was labeled. Demographic detail including name, age, gender, and BMI was noted. Echogenicity and size of the thyroid gland was compared to that of encompassing glandular parenchyma. The data collected were analyzed and interpreted using SPSS version 20. Results: The patient’s mean age was 59.92 ± 11.03 years with the ratio being 1.2:1 between males and females respectively. Diabetes and hypertension were existent in 43(39.1%) and 54(49.1%) patients respectively. Family history of thyroid nodules was present in 31(28.2%) patients. Thyroid nodule was detected in 34(30.91%) patients. The Benign pattern of thyroid nodules on grayscale. However, the histologic pattern of a mildly differentiated follicular thyroid carcinoma was detected. Conclusion: The frequency of incidental detection of thyroid nodule on carotid color Doppler ultrasound was 30.91% in patients presenting with cerebrovascular diseases. Keywords: Carotid Color Doppler Ultrasound; Incidental Detection; Cerebrovascular; Thyroid Nodule.

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Prevalence of Thyroid Incidentalomas from 1995 to 2016: A Single-Center, Retrospective Cohort Study

Cited by 21 publications

References 13 publications

Evaluating the Rising Incidence of Thyroid Cancer and Thyroid Nodule Detection Modes

Evaluating the Rising Incidence of Thyroid Cancer and Thyroid Nodule Detection Modes

Should Small Low-Risk Papillary Thyroid Cancer Be Called Cancer at All?

Incidental Detection of Thyroid Nodule on Carotid Color Doppler Ultrasound in Patients Presenting with Cerebrovascular Diseases

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