Prevalence of Toxoplasmosis Among Cancer Patients.

Hamid., DaniahM

doi:10.21474/ijar01/4846

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…According to other study, the level of IgG among breast cancer patient was (220.72 IU/ml) but in control groups with Toxoplasma infection was (140.58 IU/ml) [23] while other study revealed the total levels of IgG antibody in patients with T. gondii group, cancer group and the control group were (87.32 IU /ml, 105.80 IU/ml, 63.26 IU/ml) respectively [24]. It is proposed that when individuals are previously infected with chronic toxoplasmosis and then get the infection with any sort of cancer, the probability of reactivation of the latent infection will be high and at the same time, the opportunity for cancer to be more aggressive will also be high [16].…”

Section: Discussionmentioning

confidence: 85%

The Association of Severe Toxoplasmosis and Some Cytokine Levels in Breast Cancer Patients

Assim

Saheb

2018

ijs

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Toxoplasma gondii is an opportunistic pathogen in which the reactivation of a latent infection can cause death in congenitally infected fetuses, newborns, and immunocompromised patients. This study aimed to determine the seropositivity of toxoplasmosis infection and the possible association with Interleukin-12 (IL-12) and Interleukin-23 (IL-23) cytokines in breast cancer patients. In this study, 190 women were enrolled. All serum samples were tested for T. gondii immunoglobulins (IgG and IgM) antibodies and (IL-12, IL-23) levels using ELISA technique. The result of this study showed that breast cancer patients recorded the highest percentage of toxoplasmosis infection. There were no positivity rates for anti-Toxoplasma IgM in breast cancer patients while the positivity percentage for anti-Toxoplasma IgM among the control group was (7.00%). Furthermore, the seroprevalence of anti-Toxoplasma IgG was the highest in the age group (31-40) years in patients with breast cancer while the highest mean titer of the IL-12 is restricted to ages (21-30) years in the control groups who are seropositive to anti-Toxoplasma IgG. Although, in patients with breast cancer who are seropositive to anti-Toxoplasma IgG, the highest mean titer of the IL-23 was in ages (21-30) years. Since most immunosuppressive patients are exposed to various possible risk factors including Toxoplasma primary infection or reactivation, so it is important to diagnose and treat toxoplasmosis in breast cancer patients to reduce the consequences of the infection.

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Section: Discussionmentioning

confidence: 85%

The Association of Severe Toxoplasmosis and Some Cytokine Levels in Breast Cancer Patients

Assim

Saheb

2018

ijs

View full text Add to dashboard Cite

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“…T oxoplasma gondii es un protozoo que infecta a un tercio de la población mundial 1 , se transmite a las personas por ingesta accidental de ooquistes procedentes de deposiciones de gato, por consumo de carne cruda de animales infectados, por vía transfusional, transplacentaria o por trasplante de órganos 1,2 . Su seroprevalencia alrededor del mundo en población general, según información disponible, varía desde 7% en Corea del Sur hasta 68% en Brasil 3 , lo que depende del área geográfica, saneamiento ambiental y las diferencias en estilo de vida 3 .…”

Section: Introductionunclassified

“…La mayoría de las series de seroprevalencia de toxoplasmosis en pacientes inmunocomprometidos han sido descritas en pacientes con síndrome de inmunodeficiencia adquirida, receptores de trasplante de órganos sólidos o de precursores hematopoyéticos, personas que reciben inmunoterapia, o bien, aquellos que sufren de enfermedades reumatológicas y mesenquimopatías de la niñez y reciben diferentes tratamientos inmunosupresores 1,2,8 . La seroprevalencia de toxoplasmosis en pacientes pediátricos con quimioterapia antineoplásica ha sido poco evaluada 8 .…”

Section: Introductionunclassified