Prevalence of Use of Herbal and Traditional Medicines

Lee, E Lyn; Barnes, Joanne

doi:10.1007/978-3-031-07275-8_2

Cited by 7 publications

(8 citation statements)

References 20 publications

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“…Aromatic and medicinal plants are broadly utilized in both modern and traditional medicine [19], with ca. 50% of the medications prescribed by doctors originating from natural sources [20]. Anacyclus pyrethrum, the pellitory, is renowned for its pharmacological properties, which encompass antinociceptive, antioxidant, antidepressant, and anticonvulsive qualities [21,22].…”

Section: Introductionmentioning

confidence: 99%

Trihexyphenidyl Alters Its Host’s Metabolism, Neurobehavioral Patterns, and Gut Microbiome Feedback Loop—The Modulating Role of Anacyclus pyrethrum

Baslam,

Azraida,

Aboufatima

et al. 2023

Antioxidants

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Trihexyphenidyl (THP)—a synthetic anticholinergic medication used to manage parkinsonism and extrapyramidal symptoms—has gained significant clinical recognition. However, there is a critical gap in understanding its withdrawal effects. This study investigates the intricate interplay between gut microbiota and oxidative stress during THP withdrawal. Furthermore, it explores the therapeutic potential of Anacyclus pyrethrum (AEAP) for alleviating the associated adverse effects. This comprehensive research combines behavioral tests, biochemical analysis, gut microbiome assessment utilizing matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS), and oxidative stress measures. The results reveal that the chronic administration of THP leads to severe withdrawal syndrome, marked by heightened anxiety, depressive-like behaviors, increased cortisol levels, elevated oxidative stress, and gut dysbiosis. However, the administration of AEAP alongside THP shows a significant capacity to mitigate these deleterious effects. Co-treatment and post-treatment with AEAP increased bacterial density and diversity, promoting the proliferation of beneficial bacteria associated with improved gut health. Furthermore, AEAP administration reduced cortisol levels and exhibited potent antioxidant properties, effectively countering the THP-induced oxidative damage. This study highlights the withdrawal effects of THP and underscores the therapeutic potential of AEAP for managing these symptoms. The findings reveal its promising effects in alleviating behavioral and biochemical impairments, reducing oxidative stress, and restoring gut microbiota, which could significantly impact the clinical management of THP withdrawal and potentially extend to other substance withdrawal scenarios.

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Section: Introductionmentioning

confidence: 99%

Trihexyphenidyl Alters Its Host’s Metabolism, Neurobehavioral Patterns, and Gut Microbiome Feedback Loop—The Modulating Role of Anacyclus pyrethrum

Baslam,

Azraida,

Aboufatima

et al. 2023

Antioxidants

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“…The composition and form of the products reported in the scoping review and both databases are highly variable due to differences in plant parts used, methods of preparation (powdered plant material, dried extracts prepared with various solvents), possible standardization, dosage, and duration of exposure [ 36 ]. This variability in plant material will impact the quality of the final product and may lead to unknown ingredient concentrations.…”

Section: Discussionmentioning

confidence: 99%

“…Concomitantly, biological activity, including safety aspects, will differ among the various products available and may be less predictable if the nature and composition are not known or disclosed in the product information. Additionally, factors such as the quality and identity of the source plant material, fluctuations in content, environmental conditions, and inadequate post-harvest handling and storage may compromise product quality and safety [ 36 ]. Determining a safe dosage and duration of exposure for products with assumed phytoestrogenic activity is challenging due to significant variations in the usage of products containing the same plant species.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Safety Concerns on Herbal Products with Assumed Phytoestrogenic Activity

et al. 2023

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Phytoestrogens (PEs) are plant-based compounds that can interact with estrogen receptors and are mainly used to treat menopausal complaints. However, the safety of products with assumed phytoestrogenic activity is not fully understood. This study aimed to identify plant species with assumed phytoestrogenic activity, review existing literature on their use and safety, and critically evaluate adverse reaction (AR) reports of single-herb, multi-herb, and mixed-multiple products, as submitted to the Netherlands Pharmacovigilance Centre Lareb and to VigiBase of the World Health Organization (WHO). In the Lareb database, the most commonly reported plant species to cause ARs (total of 67 reports) were Actaea racemosa L. (black cohosh) (47.8%), Humulus lupulus L. (hops) (32.8%), and Glycine max (L.) Merr. (soybean) (22.4%). In the VigiBase database (total of 21,944 reports), the top three consisted of Glycine max (L.) Merr. (71.4%), Actaea racemosa L. (11.6%), and Vitex agnus-castus L. (chaste tree) (6.4%). In the scoping review (total of 73 articles), Actaea racemosa L. (30.1%), Glycine max (L.) Merr. (28.8%), and Trifolium pratense L. (13.7%) were the most frequently mentioned plant species. ARs were most frequently reported in the system organ classes “gastrointestinal disorders”, “skin and subcutaneous tissue disorders”, “reproductive system and breast disorders”, and “general disorders and administration site conditions”. Furthermore, from the scoping review, it appeared that the use of products with assumed phytoestrogenic activity was associated with postmenopausal bleeding. It was concluded that, while the potential benefits of products with assumed phytoestrogenic activity have been extensively pursued, the potential occurrence of ARs after using these products is less well understood. This study highlights the need for further investigation and careful monitoring of these products to better understand their effects and ensure the safety and well-being of individuals using them.

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“…5 However, the prevalence of IHM use by pregnant women varies across countries owing to differences in access, regulations, cultural aspects, historical influence, socioeconomic levels and conventional healthcare system progress. [6][7][8][9][10] Generally, the prevalence of use is higher in low-income countries where access to conventional healthcare is inadequate, TM is protuberant due to its cultural and historical reputation, and TM is one of the key sources, or sometimes the only available basis of healthcare. 10 In Africa, including Ethiopia, the prevalence of IHMs is high and widely used by pregnant women and the population too.…”

Section: Open Accessmentioning

confidence: 99%

“…[6][7][8][9][10] Generally, the prevalence of use is higher in low-income countries where access to conventional healthcare is inadequate, TM is protuberant due to its cultural and historical reputation, and TM is one of the key sources, or sometimes the only available basis of healthcare. 10 In Africa, including Ethiopia, the prevalence of IHMs is high and widely used by pregnant women and the population too. 3 11-14 For instance, a systematic review of studies in Africa shows the prevalence rate varying from 12% to 60%.…”

Section: Open Accessmentioning

confidence: 99%

Indigenous herbal medicine use and its associated factors among pregnant women attending antenatal care at public health facilities in Dire Dawa, Ethiopia: a cross-sectional study

Mohammed,

Amsalu,

Hailu

et al. 2024

BMJ Open

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ObjectiveThe aim of this study was to investigate the prevalence of indigenous herbal medicine use and its associated factors among pregnant women attending antenatal care (ANC) at public health facilities in Dire Dawa, Ethiopia.DesignA facility-based cross-sectional study design.SettingThe study was conducted in seven public health facilities (one referral hospital, three urban and three rural health centres) in Dire Dawa, Ethiopia, from October to November 2022.Participants628 pregnant women of any gestational age who had been on ANC follow-up at selected public health facilities were included.Main outcome measuresPrevalence of indigenous herbal medicine (users vs non-users) and associated factors.ResultsThe study revealed that 47.8% (95% CI 43.8% to 51.6%) of pregnant women used herbal medicines. Lack of formal education (adjusted OR, AOR 5.47, 95% CI 2.40 to 12.46), primary level (AOR 4.74, 95% CI 2.15 to 10.44), housewives (AOR 4.15, 95% CI 1.83 to 9.37), number of ANC visits (AOR 2.58, 95% CI 1.27 to 5.25), insufficient knowledge (AOR 4.58, 95% CI 3.02 to 6.77) and favourable perception (AOR 2.54, 95% CI 1.71 to 3.77) were factors significantly associated with herbal medicine use. The most commonly used herbs were garden cress (Lepidium sativum) (32%), bitter leaf (Vernonia amygdalina) (25.2%), moringa (Moringa oleifera) (24.5%).Commonindications were related to gastrointestinal problems, blood pressure and sugar.ConclusionThe prevalence of herbal medicine use is high (one in two pregnant women) and significantly associated with education level, occupation, ANC visits, knowledge and perceptions. The study’s findings are helpful in advancing comprehension of herbal medicines using status, types and enforcing factors. It is essential that health facilities provide herbal counselling during ANC visits, and health regulatory bodies ought to raise awareness and implement interventions to lower the risks from over-the-counter herbal medicine use by pregnant women.

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Prevalence of Use of Herbal and Traditional Medicines

Cited by 7 publications

References 20 publications

Trihexyphenidyl Alters Its Host’s Metabolism, Neurobehavioral Patterns, and Gut Microbiome Feedback Loop—The Modulating Role of Anacyclus pyrethrum

Trihexyphenidyl Alters Its Host’s Metabolism, Neurobehavioral Patterns, and Gut Microbiome Feedback Loop—The Modulating Role of Anacyclus pyrethrum

Analysis of Safety Concerns on Herbal Products with Assumed Phytoestrogenic Activity

Indigenous herbal medicine use and its associated factors among pregnant women attending antenatal care at public health facilities in Dire Dawa, Ethiopia: a cross-sectional study

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