Prevalence of Vitamin D Deficiency and Insufficiency in Northeast Tennessee

Kuriacose, Reena; Olive, Kenneth E.

doi:10.1097/smj.0b013e318181881b

Cited by 10 publications

(5 citation statements)

References 17 publications

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“…Mean calcium levels were 2.24 ± < 0.01 mmol/L for men, (α2 = 55.175; p < 0.001). Using generalised estimating equations analysis with odds ratios and adjusting for the covariate of age (Table II), we found that all the years prior to 2010 were associated with higher odds of vitamin D deficiency to Our data indicated that vitamin D deficiency was clearly prevalent in our population -(i) the frequency distribution of (29,32,33) and Denmark, (34) where a high degree of vitamin D deficiency was seen among the populations studied. According to Hirani et al, women were more likely to be vitamin D deficient than men.…”

Section: E Th O Dsmentioning

confidence: 84%

Vitamin D deficiency remains prevalent despite increased laboratory testing in New South Wales, Australia

Quaggiotto¹,

Tran²,

Bhanugopan³

2014

smedj

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INTRODUCTIONCONCLUSION We found that vitamin D deficiency was prevalent in both men and women, with a higher prevalence in the latter, despite the substantial increased demand for 25(OH)D testing in our population over the decade. Vitamin D deficiency was associated with elevated PTH levels. Vitamin D toxicity was rare and only observed once during our study period. 25(OH)D levels decreased with age and varied with season, with the highest levels observed in late summer and the lowest in early spring.

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Section: E Th O Dsmentioning

confidence: 84%

Vitamin D deficiency remains prevalent despite increased laboratory testing in New South Wales, Australia

Quaggiotto¹,

Tran²,

Bhanugopan³

2014

smedj

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“…All of the patients had one of the AITD (GD or HT) and Vitamin D deficiencies defined as serum values <20 ng/mL. [171819]…”

Section: Methodsmentioning

confidence: 99%

Effects of Vitamin D treatment on thyroid autoimmunity

et al. 2016

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Background:Vitamin D was shown to be related to autoimmune thyroid diseases (AITDs) in the previous studies. We aimed to investigate the relationship between Vitamin D and thyroid autoimmunity.Materials and Methods:Eighty-two patients, diagnosed with AITD by the endocrinology outpatient clinic, were included in this prospective study. All of the patients had both AITD and Vitamin D deficiency, defined as serum values <20 ng/mL. They were randomly assigned into two groups. The first group included 46 patients and the second one included 36 patients. The first group was treated with Vitamin D for 1 month at 1000 IU/day. The second group served as the control group and was not treated with Vitamin D replacement. Serum thyroid-stimulating hormone, free T4 (fT4), thyroid peroxidase antibody (TPO-Ab), thyroglobulin antibody (TgAb), and Vitamin D levels were measured at the initiation of the study and again at 1 month in all patients.Results:Two groups were similar with regard to age, sex, and type of thyroid disease. Whereas TPO-Ab (before; 278.3 ± 218.4 IU/ml and after; 267.9 ± 200.7 IU/ml) and TgAb (before; 331.9 ± 268.1 IU/ml and after; 275.4 ± 187.3 IU/ml) levels were significantly decreased by the Vitamin D replacement therapy in group 1 (P = 0.02, P = 0.03, respectively), the evaluated parameters in the control group did not significantly change (P = 0.869, P = 0.530, respectively). In addition, thyroid function tests did not significantly change with Vitamin D replacement in two groups.Conclusion:Vitamin D deficiency may contribute to the pathogenesis of AITDs. Since supplementation of the Vitamin D decreased thyroid antibody titers in this study in Vitamin D deficient subjects, in the future Vitamin D may become a part of AITDs' treatment, especially in those with Vitamin D insufficiency. Further clinical and experimental studies are required to understand the effect of Vitamin D on AITD.

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“…Recent evidence suggests that vitamin D is a key regulator of the immune system, 12 and as such, it may play an important role in patient susceptibility to hospital‐acquired infections, 13 including HACDIs 14 . Given that the prevalence of suboptimal levels of 25‐hydroxyvitamin D (25(OH)D) has increased in the general population, 15 – 19 we performed a 2‐center retrospective cohort study of hospitalized adult patients among whom 25(OH)D was measured within 1 year of hospitalization. Our objective was to test the hypothesis that vitamin D status before hospital admission is associated with the risk of developing HACDIs.…”

Section: Introductionmentioning

confidence: 99%

Association Between Prehospital Vitamin D Status and Hospital‐Acquired Clostridium difficile Infections

Quraishi

Litonjua

Moromizato

et al. 2014

J Parenter Enteral Nutr

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Objective To investigate whether preadmission 25-hydroxyvitamin D (25(OH)D) levels are associated with the risk of hospital-acquired Clostridium difficile infection (HACDI). Materials and Methods Our retrospective cohort study focused on 568 adult patients from 2 Boston teaching hospitals between August 1993 and November 2006. All patients had 25(OH)D levels measured before hospitalization and were at risk for HACDI (defined as the presence of C difficile toxin A or B in stool samples obtained >48 hours after hospitalization). We performed multivariable regression analyses to test the association of prehospital 25(OH)D levels with HACDI while adjusting for clinically relevant covariates. Results In these 568 patients, mean (SD) 25(OH)D level was 19 (12) ng/mL, and 11% of patients met criteria for incident HACDI. Following adjustment for age, sex, race (nonwhite vs white), patient type (medical vs surgical), and Deyo-Charlson index, patients with 25(OH)D levels <10 ng/mL had higher odds of HACDI (odds ratio [OR], 2.90; 95% confidence interval [CI], 1.01–8.34) compared with patients with 25(OH)D levels ≥30 ng/mL. When patients with HACDI were analyzed relative to a larger patient cohort without HACDI (n = 5047), those with 25(OH)D levels <10 ng/mL (OR, 4.96; 95% CI, 1.84–13.38) and 10–19.9 ng/mL (OR, 3.36; 95% CI, 1.28–8.85) had higher adjusted odds of HACDI compared with patients with 25(OH)D levels ≥30 ng/mL. Conclusions In our cohort of adult patients, vitamin D status before hospital admission was inversely associated with the risk of developing HACDI. These data support the need for randomized, controlled trials to test the role of vitamin D supplementation to prevent HACDI.

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Prevalence of Vitamin D Deficiency and Insufficiency in Northeast Tennessee

Abstract: Vitamin D deficiency is highly prevalent in all age groups and in both females and males in this population. Clinicians should consider measuring the vitamin D level of all inpatients on a routine basis.

Cited by 10 publications

References 17 publications

Vitamin D deficiency remains prevalent despite increased laboratory testing in New South Wales, Australia

Vitamin D deficiency remains prevalent despite increased laboratory testing in New South Wales, Australia

Effects of Vitamin D treatment on thyroid autoimmunity

Association Between Prehospital Vitamin D Status and Hospital‐Acquired Clostridium difficile Infections

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