Vitamin D deficiency remains prevalent despite increased laboratory testing in New South Wales, Australia

Abstract

INTRODUCTIONCONCLUSION We found that vitamin D deficiency was prevalent in both men and women, with a higher prevalence in the latter, despite the substantial increased demand for 25(OH)D testing in our population over the decade. Vitamin D deficiency was associated with elevated PTH levels. Vitamin D toxicity was rare and only observed once during our study period. 25(OH)D levels decreased with age and varied with season, with the highest levels observed in late summer and the lowest in early spring.

Is There Any Threshold for Vitamin D That Elevates Parathyroid Hormone

“…Supporting data from past studies, PTH levels were higher in vitamin D deficient than in vitamin D insufficient patients along with a negative correlation between 25(OH) D and PTH in the present study [12] [17] [26] [27] [28].…”

“…In a retrospective study to analyze the biochemical results stored in the database of a pathology laboratory, it was reported that 33% of 3745 men and 40% of 6754 women were vitamin D deficient to some degree (25[OH] D ≤ 50 nmol/L) along with a significant negative association between PTH and 25(OH) D, while a significant positive association between calcium and 25(OH) D levels [12]. Supporting data from past studies, PTH levels were higher in vitamin D deficient than in vitamin D insufficient patients along with a negative correlation between 25(OH) D and PTH in the present study [12] [17] [26] [27] [28].…”

“…Indeed, data from some studies indicated an association between vitamin D deficiency and elevated PTH levels [12] [29] [30] [31] [32] leading consideration of the theoretical plateau in PTH as 25(OH) D increases to be used as a determinant in establishing the adequacy of vitamin D status [33]. However it should be noted that while 25(OH) D and PTH levels are inversely related, less than half of the patients with a low vitamin D level have been confirmed to have an elevated PTH, and, in most of these patients, the PTH does not immediately normalize with correction of the vitamin D [27] [34].…”

“…Owing to greater awareness within the medical community regarding the importance of poor vitamin D status as a public health problem affecting almost every second person worldwide [2] [9] [10] [11], the interest in the biology of vitamin D and vitamin D deficiency and thereby the demand for vitamin D testing has increased dramatically in the last 2 decades [12] [13] [14].…”

Çukurova Bölgesinde D vitamini düzeyleri

“…Serum veya plazma 25-hidroksi-D3 [25(OH)D3] düzeyi, D vitamininin besinsel ve fonksiyonel durumunu yansıtan en iyi gösterge olarak kabul edilir. Bunun nedeni; 25(OH) D3'ün uzun yarılanma ömrüne (15 ile 35 gün) sahip olması ve kanda yüksek konsantrasyonlarda bulunmasındandır 1,5,6 .…”