Vitamin D deficiency as a risk factor for endometriosis in Iranian women

Delbandi, Ali‐Akbar; Torab, Mansour; Abdollahi, Elaheh; Khodaverdi, Sepideh; Rokhgireh, Samaneh; Moradi, Zahra; Heidari, Samaneh; Mohammadi, Tahereh

doi:10.1016/j.jri.2020.103266

Cited by 20 publications

(28 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Also, a negative correlation between vitamin D levels and the severity of endometriosis was observed in that study 20 . We also showed lower serum and PF levels of 25(OH)D3 in the patients with endometriosis compared with controls 21 . Regarding 1,25‐dihydroxyvitamin D3 (1,25(OH)2D3) serum concentration results were controversial 22 .…”

Section: Introductionmentioning

confidence: 69%

“… 20 We also showed lower serum and PF levels of 25(OH)D3 in the patients with endometriosis compared with controls. 21 Regarding 1,25‐dihydroxyvitamin D3 (1,25(OH)2D3) serum concentration results were controversial. 22 The genomic pathway responsible for vitamin D activity is regulated by vitamin D receptor (VDR), which is expressed in many tissues and numerous tumours.…”

Section: Introductionmentioning

confidence: 99%

“…20 We also showed lower serum and PF levels of 25(OH)D3 in the patients with endometriosis compared with controls. 21 Regarding 1,25-dihydroxyvitamin D3…”

mentioning

confidence: 99%

See 2 more Smart Citations

Changes in MCP‐1, HGF, and IGF‐1 expression in endometrial stromal cells, PBMCs, and PFMCs of endometriotic women following 1,25(OH)2D3 treatment

Heidari

Kolahdouz‐Mohammadi

Khodaverdi

et al. 2022

J Cellular Molecular Medi

Self Cite

View full text Add to dashboard Cite

1,25(OH)2D3 has anti‐inflammatory and growth inhibitory effects. Our study explored the effect of 1,25(OH)2D3 treatment on the expression of monocyte chemotactic protein‐1 (MCP‐1), hepatocyte growth factor (HGF), and insulin‐like growth factor‐1 (IGF‐1) by peripheral blood mononuclear cells (PBMCs), peritoneal fluid mononuclear cells (PFMCs), endometrial stromal cells (ESCs), and its effect on the proliferation of PBMCs and PFMCs of patients with endometriosis compared with controls. PBMCs, PFMCs, and ESCs were obtained from 10 endometriosis patients and 10 non‐endometriotic individuals. After treating cells with 0.1 μM of 1,25(OH)2D3 for 6, 24, and 48 h, the gene and protein expression of mentioned factors were evaluated by real‐time PCR and ELISA methods, respectively. 1,25(OH)2D3 treatment significantly reduced the protein expression of MCP‐1, HGF, and IGF‐1 in PBMCs and PFMCs of endometriotic patients at 48 h (p < 0.05–<0.01). Also, this treatment significantly reduced MCP‐1, HGF, and IGF‐1 gene and/or protein expression in EESCs and EuESCs at 24 and 48 h (p < 0.05–<0.01). 1,25(OH)2D3 treatment also reduced the proliferation of PBMCs and PFMCs of endometriotic patients compared with controls (p < 0.01). 1,25(OH)2D3 can be considered as a potentially effective agent in the prevention and treatment of endometriosis along with other therapies.

show abstract

Section: Introductionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Changes in MCP‐1, HGF, and IGF‐1 expression in endometrial stromal cells, PBMCs, and PFMCs of endometriotic women following 1,25(OH)2D3 treatment

Heidari

Kolahdouz‐Mohammadi

Khodaverdi

et al. 2022

J Cellular Molecular Medi

Self Cite

View full text Add to dashboard Cite

show abstract

“…This research used vitamin D administered as physiologically as possible via the oral route. Although the optimal dose for immune system modulation in endometriosis is still unknown, vitamin D deficiency is related to endometriosis ( Anastasi et al ., 2017 ; Ciavattini et al ., 2017 ; Delbandi et al ., 2021 ). Thus, this study estimated that the effective dose modulating the expression of IL-17 in endometriosis refers to the deficiency correction dose recommended by the Endocrine Society ( Holick et al ., 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D inhibited endometriosis development in mice model through interleukin 17 modulation

Burjiah¹,

adi²,

Widjiati³

2022

Open Vet J

View full text Add to dashboard Cite

Background: Endometriosis is a common benign, estrogen-dependent, and chronic gynecological disease. Immune system disturbances and inflammatory abnormalities were involved in the pathogenesis of endometriosis. , Therefore, it is logical to use vitamin D, which has an immunomodulatory capacity, as supportive therapy for endometriosis. Aims: This research time to study the effect of different doses of vitamin D on IL-17 expression in endometriosis mice models. Methods: Endometriosis was induced in twenty-four mice divided into four groups of six. Group C received no treatment, while groups T1, T2, and T3 received graded doses of vitamin D to the stomach, sequentially 8 IU, 16 IU, and 24 IU for three weeks. Interleukin-17 expression and the extent of endometriotic peritoneal lesions were also measured and analyzed. Statistical tests were performed to see the difference in the mean area of endometriosis lesions and IL-17 expression between the control and treatment groups, as well as the correlation between the extent of endometriosis lesions and IL-17. We performed a statistical test to determine whether stratified doses have different IL-17 and endometriosis area outcomes. Results: The area of endometriosis lesions was decreased after 16 IU and 24 IU of vitamin D administration (p 0.023 and 0.009). Endometriosis lesions also tended to be smaller after 8 IU of vitamin D supplementation, although insignificant (p > 0.05). Interleukin-17 expression was significantly lower after 24 IU vitamin D administration (p = 0.004). Vitamin D doses of 8 IU and 16 IU caused lower IL-17 expression, although not significant (p = 0.452 and p = 0.645). The regulation of IL-17 expression was significantly dependent on the dose level of vitamin D with an optimal dose of 24 IU (p = 0.004). This dose also caused the smallest endometriosis lesion, although not optimal (p > 0.05). IL-17 expression was moderately and positively correlated with the extent of endometriosis lesions (p = 0.012, rho = 0.505). Conclusion: By modulating the expression of interleukin-17 in endometriotic lesions, vitamin D inhibits the development of endometriotic lesions in the endometriosis mice model. The optimal vitamin D dose in this study was 24 IU.

show abstract

“…Зрив адаптаційних механізмів у підлітковому віці призводить до активації поліморфних генів, які спри-Л. М. Семенюк 1 , Т. Ю. Юзвенко 1 , Є. С. Козачук 1 , Л. С. Чернуха 1 , О. І. Крижанівська 2 [14,15]. При виконанні науково-дослідної роботи «Розробка, вдосконалення та впровадження нових методів діагностики і лікування сексуальної дисфункції у жінок різного віку із дефіцитом андрогенів» (№ 0122U001153) у 2022 -2024 рр.…”

unclassified

Improvement of diagnostic methods of reproductive health disorders in women of early reproductive age with sexual dysfunction and hypoandrogenism

Semenyuk¹,

Yuzvenko²,

Козачук³

et al. 2023

CE&ES

View full text Add to dashboard Cite

Female sexual dysfunction (FSD) is a global health problem. This is a multifaceted problem that requires the coordinated interaction of many neurotransmitters and hormones, both central and peripheral. In young women with reproductive health problems, the first clinical signs of future imbalances manifest in adolescence. Disruption of adaptation mechanisms at this age leads to the activation of polymorphic genes, resulting in the multifunctional disorders of women’s health in the future. In particular, the role of vitamin D deficiency as a trigger in the formation of many immune‑hormonal imbalances is noted, including formation of methionine metabolism disorders and the accumulation of excess homocysteine in cells. Therefore, improving methods of diagnosing reproductive health disorders in women of early reproductive age with sexual dysfunction and hypoandrogenism can be considered as a method of preventing the formation of conditions in them for future fertility disorders, decreased ovarian reserve, and infertility. Objective — to improve methods to diagnose the reproductive health disorders in women of early reproductive age with sexual dysfunction and hypoandrogenism. Materials and methods. The research included 20 women of early reproductive age with symptoms of FSD and hypoandrogenism (group I) and 20 healthy women (group II). The hormonal reproductive background was determined on the 5—7th day of the menstrual cycle in all examined women, including levels of thyroid‑stimulating hormone (TSH), antibodies to thyroid peroxidase (TPO‑Ab), vitamin D, homocysteine. IBM SPSS Statistics version 25.0 software was used for statistical processing of the obtained data. Results. Vitamin D deficiency significantly raised the probability of decreased levels of luteinizing hormone (LH) (R2=0.705; p<0.001), estradiol (R2=0.320; p=0.022), free testosterone (R2=0.419; p=0.007), dihydroepiandrosterone sulfate (DHEA‑S) (R2=0.697; p<0.001) and increased levels of prolactin (R2=0.691; p<0.001), 17‑OP (R2=0.748; p<0.001). Hyperhomocysteinemia did not significantly affected the changes in the levels of these hormones (p>0.05), but significantly increases the probability of decreased FSH levels (R2=0.376; p=0.012). Moreover, it was established that high TSH levels increased the probability of elevation homocysteine rates (R2=0.561; p=0.001) and decreased levels of reproductive hormones: FSH (R2=0.357; p=0.014), LH (R2=0.626; p<0.001), estradiol (R2=0.451; p=0.004), free testosterone (R2=0.587; p=0.001) and DHEA‑S (R2=0.661; p<0.001). The increased TPO‑Ab levels can serve as a significant predictor of the increased prolactin levels (R2=0.675; p<0.001). Conclusions. Optimization of the medical care to women with FSD should include early diagnosis of vitamin D status and evaluation of homocysteine levels. Determination of women’s hormonal background should include assessments of the levels of TSH and antibodies to thyroperoxidase. An endocrinologist’s consultation is required in case of the reveal of thyroid gland disorders. The assessments of polymorphism of folate‑methionine cycle genes and thrombophilia should be performed in case of high levels of homocysteine.

show abstract

Vitamin D deficiency as a risk factor for endometriosis in Iranian women

Cited by 20 publications

References 49 publications

Changes in MCP‐1, HGF, and IGF‐1 expression in endometrial stromal cells, PBMCs, and PFMCs of endometriotic women following 1,25(OH)2D3 treatment

Changes in MCP‐1, HGF, and IGF‐1 expression in endometrial stromal cells, PBMCs, and PFMCs of endometriotic women following 1,25(OH)2D3 treatment

Vitamin D inhibited endometriosis development in mice model through interleukin 17 modulation

Improvement of diagnostic methods of reproductive health disorders in women of early reproductive age with sexual dysfunction and hypoandrogenism

Contact Info

Product

Resources

About