Prevalence, risk-factors, and antimicrobial susceptibility profile of methicillin-resistant Staphylococcus aureus (MRSA) obtained from nares of patients and staff of Sokoto state-owned hospitals in Nigeria

Adeiza, Shuaibu Suleiman; Onaolapo, Josiah Ademola; Olayinka, Busayo Olalekan

doi:10.3205/dgkh000360

Cited by 6 publications

(1 citation statement)

References 52 publications

(27 reference statements)

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“…Moreover, the overall incidence of MRSA isolation is gradually increasing. There are reports on the prevalence of HA-MRSA in some parts of Nigeria (Adeiza et al, 2020;Obajuluwa et al, 2015;Udobi et al, 2013), but only few reports exist on nasal carriage of MRSA among students, among which are: 61.8% from undergraduate students of a private university in Ogun State (Alli et al, 2022); 32.7% from healthy students of University of Jos (Olorunfemi et al, 2021); 4% from medical students in a private university in Ogun State (Ajani et al, 2020); 22.6% among staff and students of Faculty of Pharmaceutical Sciences, Nnamdi Azikwe University Awka (Ike et al, 2016). No case of MRSA among students in Kaduna State has been reported.…”

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Prevalence and Antibiogram of Methicillin Resistant Staphylococcus aureus Nasal Carriage among Apparently Healthy University Staff and Students in Kaduna, Nigeria

Obajuluwa,

Parom,

Kubau

2024

jasem

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Methicillin Resistant Staphylococcus aureus (MRSA) has been frequently implicated in healthcare-associated infections. Hence, the objective of this paper was to investigate the prevalence and antibiogram of methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage among apparently healthy University staff and students in Kaduna, Nigeria. A total of 250 nasal swab samples were collected alongside demographic data. Gram staining and biochemical tests were carried out to identify the Staphylococcus aureus. Methicillin-resistance was determined phenotypically using cefoxitin disc. Antibiotics susceptibility testing of the MRSA isolates was carried out using agar diffusion method and the multidrug resistance determined. Out of the 250 nasal samples collected, 41 (16.4%) were confirmed to be S. aureus, out of which 25(61.0%) were methicillin resistant. Students from Faculties of Science and Medicine harboured higher percentages of MRSA (69.2% and 60.0%, respectively) in their nasal cavity. Gentamicin (84%) and ciprofloxacin (72%) were the most active antibacterial agents against the MRSA isolates. High level of resistance was recorded amongst the MRSA isolates to amoxicillin (80.0%), cotrimoxazole (52.0%), erythromycin (32.0%) and streptomycin (32.0%).Multidrug resistance was recorded in 48% of the MRSA isolates. In conclusion, there was a high prevalence of MRSA (61.0%) among Staff and students of Kaduna State University. Irrational use of antibiotics especially in the community and without prescription might be responsible for this.

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confidence: 99%

Prevalence and Antibiogram of Methicillin Resistant Staphylococcus aureus Nasal Carriage among Apparently Healthy University Staff and Students in Kaduna, Nigeria

Obajuluwa,

Parom,

Kubau

2024

jasem

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Nasal carriage of virulent and multidrug resistant Staphylococcus aureus: a possible comorbidity of COVID-19

Fowora,

Aiyedogbon,

Omolopo

et al. 2024

Mol Biol Rep

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Prospects for Antibacterial Discovery and Development

et al. 2021

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The rising prevalence of multidrug-resistant bacteria is an urgent health crisis that can only be countered through renewed investment in the discovery and development of antibiotics. There is no panacea for the antibacterial resistance crisis; instead, a multifaceted approach is called for. In this Perspective we make the case that, in the face of evolving clinical needs and enabling technologies, numerous validated antibacterial targets and associated lead molecules deserve a second look. At the same time, many worthy targets lack good leads despite harboring druggable active sites. Creative and inspired techniques buoy discovery efforts; while soil screening efforts frequently lead to antibiotic rediscovery, researchers have found success searching for new antibiotic leads by studying underexplored ecological niches or by leveraging the abundance of available data from genome mining efforts. The judicious use of “polypharmacology” (i.e., the ability of a drug to alter the activities of multiple targets) can also provide new opportunities, as can the continued search for inhibitors of resistance enzymes with the capacity to breathe new life into old antibiotics. We conclude by highlighting available pharmacoeconomic models for antibacterial discovery and development while making the case for new ones.

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Prevalence, risk-factors, and antimicrobial susceptibility profile of methicillin-resistant Staphylococcus aureus (MRSA) obtained from nares of patients and staff of Sokoto state-owned hospitals in Nigeria

Cited by 6 publications

References 52 publications

Prevalence and Antibiogram of Methicillin Resistant Staphylococcus aureus Nasal Carriage among Apparently Healthy University Staff and Students in Kaduna, Nigeria

Prevalence and Antibiogram of Methicillin Resistant Staphylococcus aureus Nasal Carriage among Apparently Healthy University Staff and Students in Kaduna, Nigeria

Nasal carriage of virulent and multidrug resistant Staphylococcus aureus: a possible comorbidity of COVID-19

Prospects for Antibacterial Discovery and Development

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