Prevalence, risk factors, and clinical patterns of chronic venous disorders of lower limbs: A population-based study in France

Carpentier, Patrick; Maricq, Hildegard R.; Biro, Christine; Ponçot-Makinen, Claire O.; Franco, A

doi:10.1016/j.jvs.2004.07.025

Cited by 337 publications

(274 citation statements)

References 27 publications

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“…The result of this study is in agreement with previous study from France. 7 This is in contrast to another study from Edinburgh, which observed male preponderance. 8 These studies were carried out several decades ago; in the mean time, changes in lifestyle may have occurred, leading to smaller differences in environmental factors that affect men and women.…”

Section: Discussioncontrasting

confidence: 97%

Prevalence and risk factors of varicose veins, skin trophic changes, and venous symptoms among northern Indian population

Agarwal¹,

Agarwal²,

Singh³

et al. 2016

Int J Res Med Sci

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Section: Discussioncontrasting

confidence: 97%

Prevalence and risk factors of varicose veins, skin trophic changes, and venous symptoms among northern Indian population

Agarwal¹,

Agarwal²,

Singh³

et al. 2016

Int J Res Med Sci

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“…patients with a history of thromboembolism were included. 13 Seide et al have reported a statistically significant relationship only in women between BMI and clinical classification.…”

Section: Discussionmentioning

confidence: 97%

Body Mass Index and Primary Chronic Venous Disease

Demir¹,

Şahin²,

Baran³

et al. 2016

Turkiye Klinikleri J Cardiovasc Sci

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he complaints secondary to lower extremity chronic venous disease (CVD) are indicators of a very important health problem, which results in substantial loss of work power. The chronic venous insufficiency (CVI) can be either primary or secondary. There is no identifiable cause in primary CVI; however the secondary CVI usually originates from prior deep vein thrombosis (DVT). Fourteen of these patients were excluded due to deep venous thrombosis. The belly/hip ratio and BMI of the remaining 186 were recorded. Presence, duration and rate of reflux, and location and number of segments with reflux were recorded. Three groups were formed according to BMI severity (normal weight: 18.5-24.9 kg/m², overweight: 25-29.9 kg/m², and obese: ≥ 30 kg/m²). These groups were evaluated for CEAP, and presence and severity of reflux. R Re es su ul lt ts s: : There were 61 men (32.1%) and 129 women (67.9%) with a range of age 15-83 (mean: 48.1±12.4) years and BMI range of 19.1-52.0 (mean: 29.8±6.1). No statistically significant relationship was noted among the CEAP categories and BMI groups. There was statistically significant relationship between number of vessels with reflux and CEAP patient groups (p<0.001). C Co on nc cl lu us si io on n: : BMI is not associated with severity of venous insufficiency. But the number of veins with reflux is strongly associated with severity of venous insufficiency. K Ke ey y W Wo or rd ds s: : Venous insufficiency; body mass index; ultrasonography, doppler Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmada Doppler ultrasonla kronik venöz yetmezlik tanısı alan hastalarda beden kitle indeksi (BKİ) ile venöz yetmezliğin derecesi arasındaki ilişki değerlendirildi. G Ge er re eç ç v ve e Y Yö ön n--t te em ml le er r: : Alt ekstremitede venöz yetmezlik şikayeti olan 200 hasta prospektif olarak değerlendirildi. Hastalar klinik, etiyoloji, anatomi, patoloji (KEAP) sınıflamasına göre kategorize edildi. Alt ekstremite venöz Doppler bulguları kayıt edildi. Ondört hasta venöz tromboz nedeniyle çalışma dışı bırakıldı. 186 hastanın bel/kalça oranları ve BKİ'leri kayıt edildi. Reflü olan segmentlerin sayıları, böl-gesi, reflü oranları ve süresi kaydedildi. BKİ'ne göre 3 grup oluşturuldu (normal kilolu: 18,5-24,9 kg/m², kilolu: 25-29,9 kg/m² ve obez: ≥30 kg/m²). Bu gruplar KEAP ve reflünün derecesine göre karşılaştırıldı. B Bu ul lg gu ul la ar r: : 15-83 yaşları (ort: 48,1±12,4) arasında 129 kadın (%67,9) ve 61 erkek (%32,1) vardı ve BKİ 19,1-52,0 (ort: 29,8±6,1) arasında idi. BKİ grupları ve KEAP kategorileri arasında istatistiksel olarak anlamlı bir ilişki bulunmadı. KEAP grupları ile reflü olan damarların sayıları arasında istatistiksel olarak anlamlı ilişki vardı (p<0.001). S So on nu uç ç: : BKİ venöz yetmezliğin derecesiyle ilişkili değildir. Reflü olan damar sayısıyla venöz yetmezliğin derecesi arasında ise güçlü bir ilişki vardır.

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“…C = normal group; V = CVI group. pregnancy, and family history have been identified (Ruckley et al 2002;Carpentier et al 2004), the molecular mechanisms underlying the pathogenesis of this disease remains vague. Various theories, such as the hemodynamic alteration causing venous hypertension (Bergan et al 2008), the incompetence of the saphenous venous valves (Duran et al 2000), the leukocyte-trapping hypothesis (Korthuis and Unthank 2000) and the weak vein wall hypothesis (Meissner et al 2007) had been put forward to explain the pathogenesis of varicose veins and CVI.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA Profiling in Great Saphenous Vein Tissues of Patients with Chronic Venous Insufficiency

Cui

Guang

Huang

et al. 2012

Tohoku J. Exp. Med.

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Chronic venous insufficiency (CVI) is a common disease characterized by structural and functional abnormalities of the venous system. Until recently, the pathogenesis of CVI remains largely unknown. MicroRNAs (miRNAs) are a family of endogenous small non-coding RNAs emerged as post-transcriptional gene repressors and play essential roles in diverse pathological processes including vascular disease. However, their roles in CVI have not been elucidated. In this study, we employed oligonucleotide microarrays to perform a genome-wide miRNAs profiling in the great saphenous vein (GSV) tissues of patients with CVI. Our results revealed a total of 14 miRNAs that are expressed differentially in GSV tissues. Among them nine miRNAs were found significantly up-regulated, while five miRNAs were downregulated significantly. Real-time RT-PCR verified statistically consistent expression of three selected miRNAs (miR-34a, miR-155 and miR-202) with microarrays analysis. These three miRNAs, which were described as crucial regulators in many biological processes and vascular diseases, might also play important roles in CVI. Functional annotation of target genes of differentially expressed miRNAs via bioinformatics approaches revealed that these predicted targets were significantly enriched and involved in several key signaling pathways important for CVI, including mitogen-activated protein kinase pathways, pathways in cancer, apoptosis, and cell cycle, and p53 signaling pathways. In summary, miRNAs might involve in multiple signaling pathways contributing to the pathological processes of CVI. These data may provide fundamental insights into the molecular basis of CVI, which may aid in designing novel approaches for prevention and treatment of this complex disease.Keywords: bioinformatics; chronic venous insufficiency; great saphenous vein; microarray; microRNA Tohoku J. Exp. Med., 2012 Dec, 228 (4), 341-350. © 2012 Tohoku University Medical Press Chronic venous insufficiency (CVI) is a complex medical condition characterized by structural and functional abnormalities of the venous system, which is commonly seen in humans. CVI is manifested with a range of signs, including varicose veins, trophic skin changes and venous ulcers. It has a considerable socioeconomic impact in many countries due to its high prevalence, cost of investigations and management, deterioration of the quality of life and loss of working days (Rabe and Pannier 2010). To date, in spite of numerous studies on CVI, the etiology and pathogenesis of CVI remains largely unknown.MicroRNAs (miRNAs) are a family of highly conserved, endogenous small non-coding RNAs (19-24nt) that post-transcriptionally repress gene expression via degradation or translational inhibition of their target mRNAs. They play important roles in nearly all physiological and pathological processes, including cell differentiation, proliferation, apoptosis, cardiovascular disease, and human cancers (Bartel 2004). There is mounting evidence suggesting that miRNAs had distinct expression profiles an...

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Prevalence, risk factors, and clinical patterns of chronic venous disorders of lower limbs: A population-based study in France

Abstract: Our results show a high prevalence of chronic venous disorders of the lower limbs in the general population of France, with no significant geographic variations. They also provide interesting insights regarding the association of varicose veins, skin trophic changes, and venous symptoms.

Cited by 337 publications

References 27 publications

Prevalence and risk factors of varicose veins, skin trophic changes, and venous symptoms among northern Indian population

Prevalence and risk factors of varicose veins, skin trophic changes, and venous symptoms among northern Indian population

Body Mass Index and Primary Chronic Venous Disease

MicroRNA Profiling in Great Saphenous Vein Tissues of Patients with Chronic Venous Insufficiency

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