Prevalence, risk factors, and management of asthma in China: a national cross-sectional study

Huang, Ke; Yang, Ting; Xu, Jun‐Fa; Yang, Lan; Zhao, Jianping; Zhang, X; Bai, Chunxue; Kang, Jian; Ran, Pixin; Shen, Huahao; Wen, Fuqiang; Chen, Y; Sun, Tieying; Shan, Guangliang; Lin, Yingxiang; Xu, Guodong; Wu, Sinan; Wang, C; Wang, R; Shi, Zhihong; Xu, Yongsheng; Ye, X; Song, Yuanlin; Wang, Q; Zhou, Yumin; Li, W; Ding, Liren; Wan, Chun; Yao, Wan-zhen; Guo, Yanfei; Xiao, Fei; Lü, Yong; Peng, Xiaoxia; Zhang, B; Xiao, Dingquan; Wang, Z; Chen, Z; Bu, Xiaoning; Zhang, H; An, Li; Zhang, S; Zhu, Jianguo; Cao, Zhixin; Zhan, Qingyuan; Yang, Yuanhua; Liang, Lirong; Tong, Xunliang; Dai, Huaping; Cao, Bin; Wu, Tangchun; Chung, Kian Fan; He, Jiang

doi:10.1016/s0140-6736(19)31147-x

Cited by 480 publications

(377 citation statements)

References 36 publications

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“…Approximately 300 million individuals are affected by asthma worldwide [1]. In China, a recent national survey showed an overall incidence of 4.2%, with about 457 million asthma cases among adults [2]. Severe bronchial asthma combined with respiratory failure is clinically diagnosed by persistent dyspnea and airway obstruction, or even more severe symptoms, which may be life-threatening.…”

Section: Introductionmentioning

confidence: 99%

High-Flow Nasal Cannula: A Promising Oxygen Therapy for Patients with Severe Bronchial Asthma Complicated with Respiratory Failure

Geng

Batu

You

et al. 2020

Canadian Respiratory Journal

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Severe bronchial asthma complicated with respiratory failure, a common critical illness in respiratory medicine, may be lifethreatening. High-flow nasal cannula (HFNC) is a novel oxygen therapy technique developed in recent years. HFNC was applied in this study for treating adult patients with severe bronchial asthma complicated with respiratory failure. Its efficacy was analyzed comparatively to conventional oxygen therapy (COT). HFNC and COT were randomly performed based on conventional treatment. e HFNC group was similar to COT-treated patients in terms of response rate, with no significant difference in efficacy between the two groups. In patients with bronchial asthma, effectively increased PO 2 and reduced PCO 2 were observed after treatment in both groups. However, HFNC was more efficient than COT in elevating PO 2 in patients with severe bronchial asthma complicated with respiratory failure, while no statistically significant difference in PCO 2 reduction was found between the two groups. Heart rate (HR) and respiratory rate (RR) between the two groups on admission (0 h) and at 2, 8, 24, and 48 h after admission were compared. Both indicators significantly decreased with time. No significant differences in HR and RR were found between the groups at 0, 2, and 8 h after admission. However, these indicators were significantly lower in the HFNC group compared with the COT group at 24 and 48 h after admission. HFNC could significantly elevate PO 2 and reduce HR and RR. us, it is a promising option for patients with severe bronchial asthma complicated with respiratory failure.

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Section: Introductionmentioning

confidence: 99%

High-Flow Nasal Cannula: A Promising Oxygen Therapy for Patients with Severe Bronchial Asthma Complicated with Respiratory Failure

Geng

Batu

You

et al. 2020

Canadian Respiratory Journal

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“…At present, Chinese people with allergic diseases account for approximately 30% of the total population (approximately 400 million), with hundreds of millions of people, especially among those who are young [28] . Based on the prevalence of childhood asthma in 2010, there were 6.7 million children with asthma in China alone.…”

Section: Discussionmentioning

confidence: 99%

Research on the improvement of allergic rhinitis in asthmatic children after reducing dust mite exposure: a randomized, double-blind, cross-placebo study protocol

Chen

Yuan

et al. 2020

Preprint

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Background: Allergic rhinitis (AR) in children has become a major respiratory inflammatory disease with a high incidence that is increasing yearly. In China, 54.93% of children with asthma have AR, which often requires synchronous treatment. House dust mites (HDMs) are common allergens that often cause attacks of AR and asthma. Reducing allergen exposure is one of the most important measures to control and treat AR and asthma attacks. Hestelia Mite Bait, containing 0.1% emamectin, is a new tool for trapping and killing dust mites that can reduce the number of dust mites on mattresses, thereby may reduce stimulation by allergens and ultimately improve asthma and rhinitis symptoms. This single-centre, randomized double-blind cross-placebo trial will explore the improvement of allergic rhinitis in asthmatic children after reducing dust mite exposure.Methods: We will recruit 60 children (aged 3-12 years) who have been diagnosed with allergic rhinitis and asthma and are allergic to dust mites as confirmed by a serum allergen test. Participants will randomly receive the Hestelia Mite Bait intervention for 8 weeks and the placebo intervention for 8 weeks. There will be a 4-week washout period between the two interventions. The primary outcome is the v isual analogue scale (VAS) score of AR symptoms; the secondary outcomes include the Rhinitis Control Assessment Test (RCAT) score, Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) score , changes in the dust mite level, drug usage for asthma and AR , Asthma Control Questionnaire-5 (ACQ-5) score, frequency of acute asthma attacks and emergency visits, and frequency of hospitalization.Discussion: This study will scientifically and objectively evaluate the improvement effect on rhinitis and asthma after reducing dust mite exposure and provide a convenient means for the prevention and treatment of children's airway allergic diseases in the future.Trial registration : ChiCTR1900024688 (www.chictr.org.cn) registration date: July 21, 2019

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“…Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, including developing countries such as China, especially with the increasing rates of obesity and Type 2 diabetes, which are the two important risk factors of CVDs [1,2]. It is estimated that in China the number of patients suffering from CVDs is up to 29 million, which will continue growing rapidly in the next 10 years [3]. It is of extreme importance to discover more effective predictors to optimize screening or preventative measures for individuals susceptible to CVDs.…”

Section: Introductionmentioning

confidence: 99%

Association of QTc Interval with Risk of Cardiovascular Diseases and Related Vascular Traits: A Prospective and Longitudinal Analysis

Deng

Niu

Luo

et al. 2020

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Background: Prolonged heart rate corrected QT (QTc) interval was reported to be associated with cardiovascular diseases (CVDs). Objective: There exists little data on the association between QTc interval and cardiovascular risk in Asian populations. We prospectively investigated the association of QTc interval with CVDs and vascular traits in a large cohort of Chinese adults. Methods: A total of 7,605 participants aged 40 years or older from a well-defined community without CVDs at baseline were included and followed up for an average of 4.5 years. Association of baseline QTc interval with incident CVDs was evaluated using Cox regression analysis. Associations of QTc interval with brachial-ankle pulse wave velocity (baPWV), carotid intimamedia thickness (CIMT), and risk of microalbuminuria and peripheral arterial diseases (PAD) were secondarily examined. Results: Prolonged QTc interval (≥460 ms in women and ≥450 ms in men) was associated with 51% higher risk of total major CVDs (hazard ratio [HR] = 1.51, 95% confidence interval [CI] [1.20, 1.90]), particularly, 48% increased risk of stroke (95% CI [1.16, 1.88]). Prolonged QTc interval was positively associated with baPWV (β = 38.10 cm/s, standard error [SE] = 8.04, P < 0.0001) and CIMT (β = 0.01 mm, SE = 0.01, P = 0.04). Prolonged QTc interval was associated with increased risk of incident microalbuminuria (odds ratio [OR] = 1.65, 95% CI [1.21, 2.24]) and PAD (2.49, 95% CI [1.35, 4.59]). Conclusions: Prolonged QTc interval is positively and significantly associated with increased risk of CVDs and related vascular traits in Chinese population.

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Prevalence, risk factors, and management of asthma in China: a national cross-sectional study

Cited by 480 publications

References 36 publications

High-Flow Nasal Cannula: A Promising Oxygen Therapy for Patients with Severe Bronchial Asthma Complicated with Respiratory Failure

High-Flow Nasal Cannula: A Promising Oxygen Therapy for Patients with Severe Bronchial Asthma Complicated with Respiratory Failure

Research on the improvement of allergic rhinitis in asthmatic children after reducing dust mite exposure: a randomized, double-blind, cross-placebo study protocol

Association of QTc Interval with Risk of Cardiovascular Diseases and Related Vascular Traits: A Prospective and Longitudinal Analysis

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