The study was conducted using a consecutive, non-random sampling technique. Results: The prevalence of primary dysmenorrhea among female medical students was 80.1%; most of the Original Article participants)n=134(reported moderate pain)49.8%(. Primary dysmenorrhea was significantly associated with caffeine consumption)p<0.05(and did not show an association with factors, body mass index, diet, lack of physical activity, and smoking. Among the SF-36 domains, the 4 domains physical health)p<0.001(and emotional health)p=0.01(including health changes)p=0.033(and pain)p<0.001(were statistically significantly affected by dysmenorrhea. Primary dysmenorrhea also had a significant impact on the students' academic performance where a higher proportion of students suffering from primary dysmenorrhea showed negative effects on their attendance, concentration, study time, and participation in class. Conclusion: Most female medical students suffer from primary dysmenorrhea, which adversely affects their quality of life and academic performance. Caffeine consumption demonstrated a significant association with primary dysmenorrhea. Periodical awareness programs to minimize the consequences of primary dysmenorrhea should be introduced.