To investigate prevalence estimates of restless legs syndrome (RLS) in relation to insomnia complaints and daytime distress a questionnaire was sent to a randomly selected sample of 1962 inhabitants of Uppsala, Sweden. The questionnaire included questions about sleep and daytime distress and the standardized four-question set for epidemiological settings recommended by the International RLS Study Group. A positive diagnosis of RLS was established in 18.8% of all responders. When the optional question about frequency was applied 5.8% reported frequent symptoms. Insomnia symptoms and daytime distress were significantly associated with the frequency of RLS symptoms.Key words: anxiety, depression, insomnia, prevalence, restless legs syndrome. R ESTLESS LEGS SYNDROME (RLS) is a sensorimotor disorder characterized by an almost irresistible urge to move the legs that may cause considerable sleep disruption and insomnia complaints.1 Surveys of the general population have shown that RLS is a common disorder, and has a prevalence ranging between 2.5 and 10%. when a four-question set recommended for epidemiological surveys also was presented. The first three questions were built upon those validated by Rothdach et al. 5 and a positive diagnosis requires affirmative answers to each of these three questions. The fourth, optional question was designed as a convenient measure of severity and had seven response categories.The proposed four-question set does not yet seem to have been used in epidemiological surveys in the normal population. Therefore, the aims of the present study were (i) to estimate the prevalence of RLS according to the proposed four-question set; and (ii) to further investigate the frequency of RLS symptoms, and the relationship between frequency of RLS symptoms and sleep disruption and daytime distress.
METHODSA questionnaire was sent out by post to a randomly selected sample of 1962 subjects aged 20-59 years living in Uppsala Municipality. Approximately every 50th person was drawn from the national registration records. Responses were obtained from 586 men and 749 women, with mean (ϮSD) ages of 39 Ϯ 12 years and 38 Ϯ 11 years, respectively.The questionnaire consisted of items from the Uppsala Sleep Inventory. 6 The four-question set recommended for use in epidemiological settings by the IRLSSG 3 was also included. These questions had been translated into Swedish by a professional translator, discussed in an expert group, and adequately