Prevalência da lesão HPV induzida em canal anal de mulheres com neoplasia intraepitelial cervical 2 e 3: um estudo de corte transversal

Heráclio, Sandra de Andrade; araujo, Thaís antunes de; Souza, Alex Sandro Rolland; Cahen, Kristiane; Junior, Sergio Lima; Souza, Paulo Roberto Eleutério de; Amorim, Melânia Maria Ramos

doi:10.1590/so100-720320150005279

Cited by 4 publications

(6 citation statements)

References 33 publications

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“…Most studies about anal intraepithelial neoplasia are performed in HIV-positive patients and in men who have sex with men. Studies in patients with immunocompetent CIN II and CIN III, as those in this study, are scarce [11].…”

Section: Discussionmentioning

confidence: 92%

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Anal cytology in immunocompetent patients with high-grade intraepithelial neoplasia (CIN II and CIN III)

Ribeiro¹,

Barbosa²,

Schnaider³

2020

Clin J Obstet Gynaecol

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Introduction: Anal cancer is directly related to the presence of high-grade HPV. Immunocompromised patients have defi ned conducts, something which is not observed in immunocompetent patients. Objective:To study the anal cytology of patients with high-grade intraepithelial neoplasia (CINII and III) in order to propose a protocol to be followed by the Oncology Gynaecology Service at the Samuel Libânio Clinical Hospital (HCSL). Methods:Clinical, prospective, transversal and single-centered study. Sampling was by convenience within one year. A total of 150 patients were studied. Out of these, 76 were patients with high-grade cervical intraepithelial lesions diagnosed through histopathological examination of the uterine cervix (Study Group) and 74 without high-grade intraepithelial lesions and with cervical cytology negative for neoplasia (Control Group). The following variables were analyzed: age, sexarc, tobacco use, alcohol consumption, STD history (not HPV), menopause, Hormone Replacement Therapy, anal sex practice, parity, number of sexual partners and contraceptive use. Results:There was no signifi cant difference between the number of cases in altered anal cancer oncology in the study group, in comparison with the control group.Conclusion: There were changes in the anal cytology of the study group and these should be evaluated due to the risk of dealing with pre-neoplastic anal lesion. Clinical Trials: NCT03241680.Anal cytology in immunocompetent patients with high-grade intraepithelial neoplasia (CIN II and CIN III) https://www.heighpubs.org/cjog 008 https://doi.

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Section: Discussionmentioning

confidence: 92%

“…Data similar to the ones in the literature were found in this research, as a considerable higher number of patients who consume alcohol beverages was observed in the study group. Heráclio, et al [11] cited more than 50% of patients with CIN II and CIN III being alcohol consumers [18].…”

Section: Discussionmentioning

confidence: 99%

Anal cytology in immunocompetent patients with high-grade intraepithelial neoplasia (CIN II and CIN III)

Ribeiro¹,

Barbosa²,

Schnaider³

2020

Clin J Obstet Gynaecol

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“…Com esses mesmos percentuais de sensibilidade e especificidade na citologia pelo teste de Papanicolau, corrobora Leeds & Fang (2016), na sua revisão sistemática. No estudo transversal de Heráclio (2015), a citologia anal apresentou alta sensibilidade (98%) e baixa especificidade (50%), todavia, no estudo de Leal et al (2020), ficou evidenciado que a citologia anal, globalmente, está descrita em 69% a 93% para a sensibilidade e de 32% a 59% para especificidade.…”

Section: Resultsunclassified

“…No recém-nascido a transmissão do HPV pode acontecer pelas vias de parto e no processo de amamentação (GARCEZ et al, 2016). A principal via de transmissão do HPV é a sexual que inclui: contato oral-genital, genital-genital ou mesmo anal-genital (BARROS; MOREIRA; MENEZES, 2021), e pelos dedos ou no contato de objetos com o canal anal (HERÁCLIO, 2015).…”

Section: Introductionunclassified

A importância do rastreamento pela citologia oncótica do câncer anal em população de risco e portadores de HIV / The importance of anal cancer oncotic cytology screening in risk population and HIV patients

Figueiredo¹,

Júnior²

2021

BJDV

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RESUMOO câncer anal é uma neoplasia comum em grupos e população de risco, as taxas de infecção tem aumentado consideravelmente e 93% dessas neoplasias são atribuídas à infecção persistente por HPV, onde a principal forma de transmissão é pela via sexual, que inclui: oral-genital, genital-genital, anal-genital, digital-genital e a utilização de objetos no ato sexual. O câncer anal tem sido associado aos fatores e população de risco como: o coito desprotegido, sexo anal receptivo, tabagismo, doenças autoimunes, múltiplos parceiros, infecções sexualmente transmissíveis (ISTs), fístula anal crônica, higiene anogenital inadequada, irritação crônica anal, pacientes imunodeprimidos, transplantados de órgãos sólidos e pessoas HIV-positivas. O objetivo deste trabalho é demonstrar a importância da citologia anal para o rastreamento das neoplasias intraepiteliais anais (NIAs), em população de risco e portadores de HIV. O estudo foi realizado por meio de uma revisão bibliográfica sistemática, através do levantamento de artigos científicos utilizando as principais bases de indexação científicas, tais como: PubMed, SciElo, Google Acadêmico, MedLine, Lilacs. Após as buscas foram encontrados 107 artigos que passaram por uma filtragem na leitura de títulos, resumos e íntegra, focando-se a temática do estudo, restaram 23 artigos que melhor refletiu o objetivo do estudo. Autores evidenciaram os fatores de risco para o desenvolvimento do câncer anal e as respectivas populações de risco, a sensibilidade e a especificidade da citologia oncótica e a importância da citologia para o rastreamento do câncer anal. A citologia anal é uma ferramenta de grande importância para a investigação e acompanhamento do câncer anal, na população de risco e principalmente em pacientes

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“…The authors explain this excellent performance by the fact that the samples were collected by medical and nursing students specially trained in the procedure. Another study by Heráclio et al 25 reported that 7% of the conventional samples were unsatisfactory. Meanwhile, Albuquerque et al 9 recommend that the proportion of unsatisfactory samples in this group should be less than 5%, while we obtained 11.25%, showing that there is room for improvement in the sample collection procedures in our institution.…”

Section: Discussionmentioning

confidence: 97%

Conventional cytologic diagnosis of human papillomavirus‐induced anal intraepithelial neoplasia: The experience of a referral center in Rio de Janeiro, Brazil

Barcellos

Coutinho

Cytryn

et al. 2022

Diagnostic Cytopathology

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Background Screening of anal cancer is rarely available or performed in Brazil. This study analyzes the diagnostic performance of conventional cytology (CC) in the prevention of anal cancer in a coloproctology and gynecology outpatient clinics in a public hospital in Rio de Janeiro, Brazil. Methods From 2005 to 2017, 1066 conventional cytological samples were collected. We analyze the causes of unsatisfactory samples (11.3%) and compare the cytological diagnoses of 83 samples from persons living with HIV and persons not living with HIV and in specific situations, using as the gold standard high‐resolution anoscopy or histopathology in cases biopsied within 6 months after cytology. Results The sensitivity of cytology with diagnosis of ASC‐US for detection of anal intraepithelial neoplasia of any grade was 85%, specificity was 41%, positive and negative predictive values were 64% and 75%, respectively, and positive and negative likelihood ratios were 1.46 and 0.35, respectively. Conclusion Conventional cytology available in resource‐limited settings is a simple, noninvasive, low‐cost method that proved feasible for outpatient screening of precursor lesions of the anal canal.

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Prevalência da lesão HPV induzida em canal anal de mulheres com neoplasia intraepitelial cervical 2 e 3: um estudo de corte transversal

Abstract: Women with CIN grade 2/3 showed a high prevalence of anal HPV infection and HPV-induced lesions.

Cited by 4 publications

References 33 publications

Anal cytology in immunocompetent patients with high-grade intraepithelial neoplasia (CIN II and CIN III)

Anal cytology in immunocompetent patients with high-grade intraepithelial neoplasia (CIN II and CIN III)

A importância do rastreamento pela citologia oncótica do câncer anal em população de risco e portadores de HIV / The importance of anal cancer oncotic cytology screening in risk population and HIV patients

Conventional cytologic diagnosis of human papillomavirus‐induced anal intraepithelial neoplasia: The experience of a referral center in Rio de Janeiro, Brazil

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