Prevalencia de la infección por Trypanosoma cruzi y transmisión vertical en mujeres gestantes latinoamericanas en un área de salud de Vizcaya

Arzanegui, Olatz Avila; Arenaza, Paloma Liendo; Indart, Lorea Martinez; Astorkiza, Txanton Martinez; Guruceta, Maria Itziar Pocheville; Arberas, María Victoria Egurbide

doi:10.1016/j.eimc.2012.01.029

Cited by 16 publications

(10 citation statements)

References 35 publications

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“…Within Spain, 7 of the 12 studies with prevalence estimates of Chagas disease in migrants were similar to the highest countrywide estimate (Del Pino and Coll, 2006; Giménez-Martí et al, 2006; Munoz-Vilches et al, 2012; Paricio-Talayero et al, 2008; Roca et al, 2011; Santiago et al, 2012; Soriano Arandes et al, 2009), two were lower(Piron et al, 2008; Ramos et al, 2012a), and three(Avila Arzanegui et al, 2013; Barona-Vilar et al, 2012; Lucas and Barba, 2009) were higher (Figure 2). One additional study was conducted in Spain, but its results are not summarized here because it was a non-representative sample of only Bolivian and Paraguayan participants (Ramos et al, 2012b).…”

Section: Resultssupporting

confidence: 57%

“…Of these studies, 11 reported higher prevalence estimates as compared to PAHO (Barona-Vilar et al, 2012; Jackson et al, 2010; Jackson et al, 2009; Lucas and Barba, 2009; Paricio-Talayero et al, 2008; Roca et al, 2011) and 6 had similar estimates (El Ghouzzi et al, 2010; Ramos et al, 2012a; Ramos et al, 2012b). For Paraguayan migrants, 3 studies had similar prevalence estimates to countrywide estimates (Ramos et al, 2012a; Ramos et al, 2012b), while 3 were higher (Figure 4) (Avila Arzanegui et al, 2013; Barona-Vilar et al, 2012; Lucas and Barba, 2009). However, it should be noted that one sample that was higher was only based on 6 individuals, and thus was very imprecise (95% CI: 3.0–56.4) (Lucas and Barba, 2009).…”

Section: Resultsmentioning

confidence: 69%

“…Contrary to most Chagas literature, younger age was associated with Chagas disease in 1 study(Lucas and Barba, 2009) and had no association in another (Roca et al, 2011). Other variables found to be significantly associated with Chagas disease included: living in a rural area (Custer et al, 2012; Muñoz et al, 2009; Roca et al, 2011), living in a mud/adobe house (Avila Arzanegui et al, 2013; Custer et al, 2012; Muñoz et al, 2009; Roca et al, 2011), hearing about Chagas disease (Roca et al, 2011), knowing someone with Chagas disease (Roca et al, 2011), having lived in a place with a thatched roof (Custer et al, 2012), having a mother or grandmother born in an endemic country (Custer et al, 2012), having a mother or family member who has had Chagas disease (Jackson et al, 2010; Lescure et al, 2009; Lucas and Barba, 2009; Ramos et al, 2012b), being bitten by a triatomine (Custer et al, 2012), or knowledge of the vector (Avila Arzanegui et al, 2013). …”

Section: Resultsmentioning

confidence: 99%

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A global systematic review of Chagas disease prevalence among migrants

et al. 2016

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Human migration has been identified as a potential factor for increased Chagas disease risk and has transformed the disease from a Latin American problem to a global one. We conducted a systematic review of the scientific literature between 2004–2014 in order to: summarize current seroprevalence estimates of Chagas disease among Latin American migrants, in both endemic and non-endemic settings; compare seroprevalence estimates in migrants to countrywide prevalence estimates; and identify risk factors for Chagas disease among migrants. A total of 320 studies were screened and 23 studies were included. We found evidence that the prevalence of Chagas disease is higher than expected in some migrant groups and that reliance on blood donor screening prevalence underestimates the burden of disease. Overall there is a dearth of high quality epidemiologic studies on the prevalence of Chagas in migrants, especially among intra-regional migrants within Latin America. Given that the disease cannot likely be eradicated, improved surveillance and reporting is vital to continuing control efforts. More accurate health surveillance of both Latin American migrants and the Chagas disease burden will help countries appropriately scale up their response to this chronic disease. Overall, improved estimates of Chagas disease among migrants would likely serve to highlight the real need for better screening, diagnostics, and treatment of individuals living with the disease.

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Section: Resultssupporting

confidence: 57%

Section: Resultsmentioning

confidence: 69%

Section: Resultsmentioning

confidence: 99%

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A global systematic review of Chagas disease prevalence among migrants

et al. 2016

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“…Three studies were undertaken in blood banks,[ 22 – 24 ] eight in antenatal units,[ 8 , 25 – 31 ] six in primary care settings or communities[ 6 , 32 – 36 ] and one study provided data both from blood bank and antenatal settings. [ 37 ] Data from 10,884 individuals was analyzed.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Chagas Disease in Latin-American Migrants Living in Europe: A Systematic Review and Meta-analysis

et al. 2015

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BackgroundFew studies have assessed the burden of Chagas disease in non-endemic countries and most of them are based on prevalence estimates from Latin American (LA) countries that likely differ from the prevalence in migrants living in Europe. The aim of this study was to systematically review the existing data informing current understanding of the prevalence of Chagas disease in LA migrants living in European countries.MethodsWe conducted a systematic review and meta-analysis of studies reporting prevalence of Chagas disease in European countries belonging to the European Union (EU) before 2004 in accordance with the MOOSE guidelines and based on the database sources MEDLINE and Global Health. No restrictions were placed on study date, study design or language of publication. The pooled prevalence was estimated using random effect models based on DerSimonian & Laird method.ResultsWe identified 18 studies conducted in five European countries. The random effect pooled prevalence was 4.2% (95%CI:2.2-6.7%); and the heterogeneity of Chagas disease prevalence among studies was high (I2 = 97%,p<0.001). Migrants from Bolivia had the highest prevalence of Chagas disease (18.1%, 95%CI:13.9–22.7%).ConclusionsPrevalence of Chagas in LA migrants living in Europe is high, particularly in migrants from Bolivia and Paraguay. Data are highly heterogeneous dependent upon country of origin and within studies of migrants from the same country of origin. Country-specific prevalence differs from the estimates available from LA countries. Our meta-analysis provides prevalence estimates of Chagas disease that should be used to estimate the burden of disease in European countries.

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“…Although there are few studies performed locally in Spain [ 16 , 26 , 27 ], to our knowledge, this is the first one addressing Chagas disease epidemiology nationwide. Moreover, the use of hospitalized data for characterizing Chagas disease epidemiology in non-endemic countries also represents a premier.…”

Section: Discussionmentioning

confidence: 99%

Using Hospital Discharge Database to Characterize Chagas Disease Evolution in Spain: There Is a Need for a Systematic Approach towards Disease Detection and Control

et al. 2015

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After the United States, Spain comes second in the list of countries receiving migrants from Latin America, and, therefore, it is the European country with the highest expected number of infected patients of Chagas disease. We have studied the National Health System’s Hospital Discharge Records Database (CMBD) in order to describe the disease evolution from 1997 to 2011 in Spain. We performed a retrospective descriptive study using CMBD information on hospitalizations including Chagas disease. Data was divided in two periods with similar length in time: 1997-2004 and 2005-2011. Hospitalization rates were calculated and clinical characteristics were described. We used multivariable logistic regression to calculate adjusted odds-ratio (aOR) for the association between various conditions and being hospitalized with organ affectation. A total of 1729 hospitalization records were identified. Hospitalization rates for the two periods were 18 and 242.8/100000 population, respectively. The median age was 35 years (range 0-87), 74% were female and the 16-45 age-group was mostly represented (69.8%). Overall, 23.4% hospitalizations included the diagnosis of Chagas disease with organ complications. Being male [aOR: 1.3 (1.00-1.77)], aged 45 and 64 years [aOR: 2.59 (1.42-4.71)], and a median hospitalization cost above 3,065 euro [aOR: 2.03 (3.73-7.86)] were associated with hospitalizations with organ affectation. Since 2005, the number of detected infections increased in Spain. The predominant patients’ profile (asymptomatic women at fertile age) and the conditions associated with organ affectation underlines the need for increased efforts towards the early detection of T cruzi.

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Prevalencia de la infección por Trypanosoma cruzi y transmisión vertical en mujeres gestantes latinoamericanas en un área de salud de Vizcaya

Cited by 16 publications

References 35 publications

A global systematic review of Chagas disease prevalence among migrants

A global systematic review of Chagas disease prevalence among migrants

Prevalence of Chagas Disease in Latin-American Migrants Living in Europe: A Systematic Review and Meta-analysis

Using Hospital Discharge Database to Characterize Chagas Disease Evolution in Spain: There Is a Need for a Systematic Approach towards Disease Detection and Control

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