Prevenção da nefrotoxicidade da anfotericina B por meio do uso de fitomedicamentos

Schlottfeldt, Fabio dos Santos; Fernandes, Sheila Marques; Martins, Daniel Malisani; Cordeiro, Priscilla Mendes; Fonseca, Cassiane Dezoti da; Watanabe, Mirian; Vattimo, Maria de Fátima Fernandes

doi:10.1590/s0080-623420150000700011

Cited by 11 publications

(7 citation statements)

References 18 publications

(35 reference statements)

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“…Diosmin, as a flavonoid glycoside, is another polyphenol with inherent antiurolithiatic activity which can be found in vegetables and citrus fruits [ 124 ]. It has been commonly used as a natural medicament for various renal diseases and protects kidneys from diabetic nephropathy, nephro-toxicity, and oxidative stress [ 125 , 126 , 127 , 128 ]. The renoprotective effects of diosmin were found attributable to its suppressing activity on lipid peroxidation, potentiating activity on antioxidant enzymes, and its modulatory effect on the expressions of Bax and p53 proteins [ 127 ].…”

Section: Effect Of Pharmacologically Active Phytochemicals On the mentioning

confidence: 99%

Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms

Nirumand

Hajialyani

Rahimi

et al. 2018

IJMS

175

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Kidney stones are one of the oldest known and common diseases in the urinary tract system. Various human studies have suggested that diets with a higher intake of vegetables and fruits play a role in the prevention of kidney stones. In this review, we have provided an overview of these dietary plants, their main chemical constituents, and their possible mechanisms of action. Camellia sinensis (green tea), Rubus idaeus (raspberry), Rubia cordifolia (common madder), Petroselinum crispum (parsley), Punica granatum (pomegranate), Pistacia lentiscus (mastic), Solanum xanthocarpum (yellow-fruit nightshade), Urtica dioica (stinging nettle), Dolichos biflorus (horse gram), Ammi visnaga (khella), Nigella sativa (black-cumin), Hibiscus sabdariffa (roselle), and Origanum vulgare (oregano) have received considerable interest based on scientific evidence. Beside these dietary plants, phytochemicals—such as catechin, epicatechin, epigallocatechin-3-gallate, diosmin, rutin, quercetin, hyperoside, and curcumin—as antioxidant dietary phyto-phenols were found to be effective for the prevention of urolithiasis (the process of stone formation in the urinary tract). The main underlying mechanisms of these dietary plants and their isolated phytonutrients in the management of urolithiasis include diuretic, antispasmodic, and antioxidant activity, as well as an inhibitory effect on crystallization, nucleation, and aggregation of crystals. The results as presented in this review demonstrate the promising role of dietary plants and phytophenols in the prevention and management of kidney stones. Further investigations are required to confirm the safety and efficacy of these compounds.

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Section: Effect Of Pharmacologically Active Phytochemicals On the mentioning

confidence: 99%

Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms

Nirumand

Hajialyani

Rahimi

et al. 2018

IJMS

175

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“…The nephrotoxic effect of AmB leads to ischemia and hypoxia in the endothelial and tubular epithelial cells with subsequent stimulation of the inflammatory response, formation of reactive oxygen species (ROS), and suppression of the antioxidant defense resulting in oxidative injury (Schlottfeldt et al, 2015 ). Oxidative stress and inflammatory cytokines have been reported to induce iNOS expression through activation of the transcription factor NF-κB (Pautz et al, 2010 , Cinelli et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Regulation of renal nitric oxide and eNOS/iNOS expression by tadalafil participates in the mitigation of amphotericin B–induced renal injury: Down-regulation of NF-κB/iNOS/caspase-3 signaling

Abdel-Rahman,

Messiha,

Ali

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Amphotericin B (AmB)–induced acute kidney injury (AKI) is a common health problem having an undesirable impact on its urgent therapeutic utility for fatal systemic fungal infections. Tadalafil (TAD), a phosphodiesterase-5 (PDE-5) inhibitor, has been observed to have a wide range of pharmacological actions, including nephroprotection. The study’s objective was to examine the possible underlying protective mechanism of TAD against AmB-induced nephrotoxicity. Experimentally, animals were divided randomly into four groups: control, TAD (5 mg/kg/day; p.o.), AmB (18.5 mg/kg/day; i.p.), and TAD+AmB groups. Sera and tissue samples were processed for biochemical, molecular, and histological analyses. The biochemical investigations showed that TAD significantly ameliorated the increase of kidney function biomarkers (creatinine, urea, CysC, KIM-1) in serum, renal nitric oxide (NO), lipid peroxidation (MDA), and inflammatory cytokines (TNF-α, IL-6) in AmB-treated rats. Meanwhile, TAD significantly retarded AmB-induced decrease in serum magnesium, sodium, potassium, and renal glutathione content. Molecular analysis revealed that TAD reduced AmB-induced imbalance in the protein expression of eNOS/iNOS, which explains its regulatory effect on renal NO content. These results were also supported by the down-regulation of nuclear NF-κB p65 and cleaved caspase-3 protein expressions, as well as the improvement of histological features by TAD in AmB-treated rats. Therefore, it can be suggested that TAD could be a promising candidate for renoprotection against AmB-induced AKI. That could be partly attributed to its regulatory effect on renal eNOS/iNOS balance and NO, the inhibition of NF-κB p65 nuclear translocation, its downstream inflammatory cytokines and iNOS, and ultimately the inhibition of caspase-3-induced renal apoptosis.

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“…Nesse cenário, observa-se que a incidência de infecções fúngicas invasivas tem aumentado, como consequência do contingente cada vez maior de pacientes com imunossupressão (5). O tratamento das infecções fúngicas com anfotericina B está associado a efeitos adversos importantes, como nefrotoxicidade.…”

Section: Discussionunclassified

Vasculite do sistema nervoso central secundária a Neurocriptococose – Relato de Caso

Pimenta

Quintino

Rodrigues

et al. 2020

VITTALLE, ISSN 1413-3563, Rio Grande, Brasil

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A meningoencefalite criptocócica é causada por fungos do gênero Cryptococcus, podendo infectar indivíduos imunossuprimidos e imunocompetentes. A infecção do sistema nervoso central (SNC) é a forma mais comum da criptococose extrapulmonar, podendo resultar em alta morbimortalidade. A doença criptocócica pode se manifestar como abscessos, meningite, granulomas e infartos e as condições que causam imunossupresão aumentam o risco de infecção do SNC. O diagnóstico é baseado em punção lombar e culturas, devendo-se ter a infecção por Cryptococcus como diagnóstico diferencial do acidente vascular cerebral, principalmente em indivíduos imunocomprometidos. O objetivo desse estudo é relatar o caso de um paciente com vasculite do SNC secundária a uma meningoencefalite criptocócica. Trata-se de uma paciente do sexo feminino, 34 anos, que fazia uso de medicação imunossupressora para controle da Doença de Crohn. Desenvolveu uma vasculite do SNC na vigência de infecção por Cryptococcus neoformans, manifestando-se com infarto cerebral, cujos achados foram confirmados nos exames de ressonância magnética do encéfalo e angiorressonância cerebral. A punção lombar apresentou o padrão típico da neurocriptococose. Tinta da China e cultura confirmaram o diagnóstico etiológico. Porém, mesmo com a terapêutica adequada, a paciente evoluiu para o óbito. Sabe-se que esse quadro de vasculite do SNC associada à infecção criptocócica é raro. Portanto, as manifestações inespecíficas dessa condição e seu início subagudo ou crônico geralmente podem levar a atrasos no diagnóstico e tratamento adequados. Assim, é importante o conhecimento dessa apresentação na neurocriptococose, uma vez que o diagnóstico e conduta precoces propiciam redução na morbimortalidade do paciente.

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Prevenção da nefrotoxicidade da anfotericina B por meio do uso de fitomedicamentos

Cited by 11 publications

References 18 publications

Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms

Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms

Regulation of renal nitric oxide and eNOS/iNOS expression by tadalafil participates in the mitigation of amphotericin B–induced renal injury: Down-regulation of NF-κB/iNOS/caspase-3 signaling

Vasculite do sistema nervoso central secundária a Neurocriptococose – Relato de Caso

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