Preventing Accidental Heterocyst Development in Cyanobacteria

Xing, Weiqin; Zhang, Cheng‐Cai

doi:10.1128/jb.00349-19

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…CalA, an AbrB‐type transcription factor, can inhibit the transcription of hepA and hetP (Higo et al, 2019). CalA may be essential in cyanobacteria, and acts as a safety device to prevent accidental heterocyst differentiation (Higo et al, 2019; Xing & Zhang, 2019). HepB (Alr3698) is a component of an ABC transporter essential for HEP layer formation (Wang et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

HetF defines a transition point from commitment to morphogenesis during heterocyst differentiation in the cyanobacterium Anabaena sp. PCC 7120

Xing,

Liu,

Zhang

2023

Molecular Microbiology

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The filamentous cyanobacterium Anabaena sp. PCC 7120 is able to form heterocysts for nitrogen fixation. Heterocyst differentiation is initiated by combined‐nitrogen deprivation, followed by the commitment step during which the developmental process becomes irreversible. Mature heterocysts are terminally differentiated cells unable to divide, and cell division is required for heterocyst differentiation. Previously, we have shown that the HetF protease regulates cell division and heterocyst differentiation by cleaving PatU3, which is an inhibitor for both events. When hetF is required during the developmental program remains unknown. Here, by controlling the timing of hetF expression during heterocyst differentiation, we provide evidence that hetF is required just before the beginning of heterocyst morphogenesis. Consistent with this finding, transcriptome data show that most of the genes known to be involved in the early step (such as hetR and ntcA) or the commitment step (such as hetP and hetZ) of heterocyst development could be expressed in the ΔhetF mutant. In contrast, most of the genes involved in heterocyst morphogenesis and nitrogen fixation remain repressed in the mutant. These results indicated that in the absence of hetF, heterocyst differentiation is able to be initiated and proceeds to the stage just before heterocyst envelope formation.

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Section: Introductionmentioning

confidence: 99%

HetF defines a transition point from commitment to morphogenesis during heterocyst differentiation in the cyanobacterium Anabaena sp. PCC 7120

Xing,

Liu,

Zhang

2023

Molecular Microbiology

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Genetic engineering contribution to developing cyanobacteria-based hydrogen energy to reduce carbon emissions and establish a hydrogen economy

Kamshybayeva

Kossalbayev

Sadvakasova

et al. 2024

International Journal of Hydrogen Energy

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The Making of a Heterocyst in Cyanobacteria

Zeng

Zhang

2022

Annu. Rev. Microbiol.

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Heterocyst differentiation that occurs in some filamentous cyanobacteria, such as Anabaena sp. PCC 7120, provides a unique model for prokaryotic developmental biology. Heterocyst cells are formed in response to combined-nitrogen deprivation and possess a microoxic environment suitable for nitrogen fixation following extensive morphological and physiological reorganization. A filament of Anabaena is a true multicellular organism, as nitrogen and carbon sources are exchanged among different cells and cell types through septal junctions to ensure filament growth. Because heterocysts are terminally differentiated cells and unable to divide, their activity is an altruistic behavior dedicated to providing fixed nitrogen for neighboring vegetative cells. Heterocyst development is also a process of one-dimensional pattern formation, as heterocysts are semiregularly intercalated among vegetative cells. Morphogens form gradients along the filament and interact with each other in a fashion that fits well into the Turing model, a mathematical framework to explain biological pattern formation. Expected final online publication date for the Annual Review of Microbiology, Volume 76 is September 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Preventing Accidental Heterocyst Development in Cyanobacteria

Cited by 3 publications

References 31 publications

HetF defines a transition point from commitment to morphogenesis during heterocyst differentiation in the cyanobacterium Anabaena sp. PCC 7120

HetF defines a transition point from commitment to morphogenesis during heterocyst differentiation in the cyanobacterium Anabaena sp. PCC 7120

Genetic engineering contribution to developing cyanobacteria-based hydrogen energy to reduce carbon emissions and establish a hydrogen economy

The Making of a Heterocyst in Cyanobacteria

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