Preventing Alzheimer disease with exercise?

Karceski, Steven

doi:10.1212/wnl.0b013e318255e0c9

Cited by 16 publications

(13 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, Kivipelto and Solomon (2007) proved that doing physical activities on a daily basis when a person was middle aged might reduce the risk of the development AD by 60%. Other research studies (Hamer and Chida, 2009;Karceski, 2012) state that the risk of developing AD is two times higher with those who do not do regular physical activities and simply stay inactive. Moreover, if these physical activities are done by elderly people who do not suffer from dementia, these individuals might reduce the risk of the development of AD by 40%.…”

Section: Current Treatment Of Admentioning

confidence: 99%

Alzheimer's disease: Potential preventive, non-invasive, intervention strategies in lowering the risk of cognitive decline - A review study

Klímová¹,

Kuča²

2015

J Appl Biomed

View full text Add to dashboard Cite

Section: Current Treatment Of Admentioning

confidence: 99%

Alzheimer's disease: Potential preventive, non-invasive, intervention strategies in lowering the risk of cognitive decline - A review study

Klímová¹,

Kuča²

2015

J Appl Biomed

View full text Add to dashboard Cite

“… 11 12 Experimental data support the theory that PE is likely to maintain and even improve cognitive and motor functions in healthy subjects. 13 It is also suggested that overall physical activity (PA) can protect against the onset of AD and PD, 14 15 16 17 and that PE can slow down the progression of these pathologies. 18 19 …”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Physical Exercise in Alzheimer's Disease and Parkinson's Disease: A Narrative Review

2015

View full text Add to dashboard Cite

Alzheimer's disease (AD) and Parkinson's disease (PD) are devastating, frequent, and still incurable neurodegenerative diseases that manifest as cognitive and motor disorders. Epidemiological data support an inverse relationship between the amount of physical activity (PA) undertaken and the risk of developing these two diseases. Beyond this preventive role, exercise may also slow down their progression. Several mechanisms have been suggested for explaining the benefits of PA in the prevention of AD. Aerobic physical exercise (PE) activates the release of neurotrophic factors and promotes angiogenesis, thereby facilitating neurogenesis and synaptogenesis, which in turn improve memory and cognitive functions. Research has shown that the neuroprotective mechanisms induced by PE are linked to an increased production of superoxide dismutase, endothelial nitric oxide synthase, brain-derived neurotrophic factor, nerve growth factor, insulin-like growth factor, and vascular endothelial growth factor, and a reduction in the production of free radicals in brain areas such as the hippocampus, which is particularly involved in memory. Other mechanisms have also been reported in the prevention of PD. Exercise limits the alteration in dopaminergic neurons in the substantia nigra and contributes to optimal functioning of the basal ganglia involved in motor commands and control by adaptive mechanisms involving dopamine and glutamate neurotransmission. AD and PD are expansive throughout our ageing society, and so even a small impact of nonpharmacological interventions, such as PA and exercise, may have a major impact on public health.

show abstract

“…The regular and repeated consistent and timely exercise increases cerebral blood flow that contributes to angiogenesis, neurogenesis, synaptogenesis, and neurotransmitter release in different cerebral areas involved in cognition (e.g., memorization) and mobility [16,17]. Experimental data support that PE can protect against the onset of AD and PD [18][19][20][21]. Indeed, physical inactivity is one of the most prominent risk factors for dementia, Parkinson's disease and Alzheimer's disease (AD) [22][23][24][25][26][27][28][29].…”

Section: What and How Physical Exercise (Pe) Can Help In Preventiomentioning

confidence: 99%

Physical Therapy for Neurodegenerative Diseases: An Educational Approach

Chakraborty¹,

Chakraborty²,

Smith³

et al. 2020

NNB

View full text Add to dashboard Cite

The most progressive neurodegenerative disease so far we know are Alzheimer’s disease (AD) and Parkinson’s disease (PD). They manifest cognitive and motor disorders, respectively. No cures are found yet for both the diseases, except some palliatives. At this stage, some alternative measures can be adopted that may slowdown the further progression and may bring comfort to the affected people. Epidemiological data supports a direct relationship between the physical activity (PA) and the risk of developing those two diseases. Aerobic physical exercise (PE) induces the release of neurotrophic factors, promotes angiogenesis, neurogenesis and synaptogenesis, and improves memory and cognitive functions. Further, PE activates the superoxide scavengers, like superoxide dismutase, endothelial nitric oxide synthase, and thereby protects the hippocampus, which is involved particularly in memory function. AD and PD not only deteriorate the quality of life but also may cause death. Therefore, any positive impact of non-pharmacological interventions, such as physical activity and exercise, would improve public health.

show abstract

Preventing Alzheimer disease with exercise?

Cited by 16 publications

References 4 publications

Alzheimer's disease: Potential preventive, non-invasive, intervention strategies in lowering the risk of cognitive decline - A review study

Alzheimer's disease: Potential preventive, non-invasive, intervention strategies in lowering the risk of cognitive decline - A review study

Protective Effects of Physical Exercise in Alzheimer's Disease and Parkinson's Disease: A Narrative Review

Physical Therapy for Neurodegenerative Diseases: An Educational Approach

Contact Info

Product

Resources

About