Preventing chronic postoperative pain

Reddi, D.

doi:10.1111/anae.13306

Cited by 97 publications

(65 citation statements)

References 69 publications

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“…As such, the physiological transduction and transmission of noxious stimuli are a vital protective mechanism, allowing withdrawal from potential damage by environmental factors. However, if this pain is not managed effectively, it may become chronic pain, harming the related organs and leading to dysfunction [10,11].…”

Section: Y H Gao and Cw LI Contributed Equally To This Workmentioning

confidence: 99%

Effect of electroacupuncture on the cervicospinal P2X7 receptor/fractalkine/CX3CR1 signaling pathway in a rat neck-incision pain model

Gao

Wang

et al. 2016

Purinergic Signalling

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Increasing evidence supports that acupuncture intervention is an effective approach for intraoperative and postoperative pain. Neuron-microglia crosstalk, mediated by the purinergic P2X7 receptor (R)/fractalkine/CX3CR1 cascade in the spinal cord dorsal horn, plays a pivotal role in pain processing. However, its involvement in the analgesic effect of electroacupuncture (EA) remains unclear. In this study, a rat neck-incision pain model was established by making a longitudinal incision along the midline of the neck and subsequent repeated mechanical stimulation. EA stimulation was applied to bilateral LI18, LI4-PC6, or ST36-GB34. The thermal pain threshold, cervicospinal ATP concentration, expression levels of purinergic P2XR and P2YR subunits mRNAs, and fractalkine, CX3CR1 and p38 MAPK proteins, were detected separately. The neck incision induced strong thermal hyperalgesia and upregulation of spinal ATP within 48 h. No significant change was found in thermal hyperalgesia after a single session of EA intervention. However, a single session of EA dramatically enhanced the neck incision-induced upregulation of ATP and upregulated the expression of P2X7R, which was reversed by two sessions of EA. Two sessions of EA at bilateral LI18 or LI4-PC6 attenuated hyperalgesia significantly, accompanied with downregulation of P2X7R/fractalkine/ CX3CR1 signaling after three sessions of EA. EA stimulation of LI18 or LI4-PC6 alleviates thermal hyperalgesia in neck-incision pain rats, which may be associated with its effects in regulating the neck incision-induced increase of ATP and P2X7R and subsequently suppressing fractalkine/CX3CR1 signaling in the cervical spinal cord.

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Section: Y H Gao and Cw LI Contributed Equally To This Workmentioning

confidence: 99%

Effect of electroacupuncture on the cervicospinal P2X7 receptor/fractalkine/CX3CR1 signaling pathway in a rat neck-incision pain model

Gao

Wang

et al. 2016

Purinergic Signalling

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“…However, the results were only found in the disc herniation group. A possible reason for the different results for patients with disc herniation may be the presence of inflammation, which often causes more on-going nociceptive stimuli and constant pain experience that could cause more risk of plasticity changes in the nervous system [6]. In disc herniation, the sciatic pain is described to have both a neuropathic component with the mechanical-stimuli causing the nerve root compression and also an inflammatory component [19].…”

Section: Discussionmentioning

confidence: 99%

“…Socio-demographic, clinical, work-related and psychological risk factors may partly explain poor outcomes after spinal surgery [5]. Another reported risk factor is insufficient pain treatment pre-and post-surgery [6]. It has been suggested that screening of somatosensory function may contribute to the understanding of pain mechanisms involved [7].…”

Section: Introductionmentioning

confidence: 99%

Association between pain sensitivity in the hand and outcomes after surgery in patients with lumbar disc herniation or spinal stenosis

et al. 2017

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Purpose To investigate the association between pain sensitivity in the hand pre-surgery, and patient-reported outcomes (PROs) in function, pain and health pre-and postsurgery in patients with disc herniation or spinal stenosis. Methods This is a prospective cohort study with 82 patients. Associations between pressure-, cold-and heat pain threshold (PPT, CPT, HPT) in the hand pre-surgery and Oswestry, VAS pain, EQ-5D, HADS, and Self-Efficacy Scale, pre-and three months post-surgery; were investigated with linear regression.Results Patients with disc herniation more sensitive to pressure pain pre-surgery showed lower function and selfefficacy, and higher anxiety and depression pre-surgery, and lower function, and self-efficacy, and higher pain postsurgery. Results for cold pain were similar. In patients with spinal stenosis few associations with PROs were found and none for HPT and PROs. Conclusions Altered pain response in pressure-and cold pain in the hand, as a sign of widespread pain pre-surgery had associations with higher pain, lower function and selfefficacy post-surgery in patients with disc herniation.

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“…Kerusakan dan inflamasi pada nervus akan memicu rasa nyeri. Rasa nyeri pasien dipengaruhi oleh berbagai faktor, termasuk psikologi dari pasien (Reddi, 2016). Menurut Yin et al (2015), 80% pasien paska operasi mengalami nyeri dan menurut Kable et al (2004), 41 % pasien paska operasi masih merasakan nyeri meskipun sudah pulang ke rumah dan 20 % merupakan pasien yang mengalami pembedahan TURP.…”

Section: Trans Urethral Resection Of Theunclassified

Pengaruh Relaksasi Benson terhadap Penurunan Nyeri Paska Bedah pada Pasien <i>Transurethral Resection of the Prostate</i>.

Sueb¹,

Triwibowo²

2018

Jur. Kep. Soed.

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Surgical intervention of transurethral resection of the prostate can cause pain and trauma. The use of non-pharmacological and pharmacology therapy can be used to reduce pain intensity in patients post-surgery. Benson Relaxation is a non-pharmacological therapy involving patient confidence factor for achieving health and welfare conditions is higher. The purpose of this study is to determine the effect of Benson relaxation to pain intensity in patients with TURP intervention. The experiment study with randomized pretest-posttest control group design was conducted. Total sampling technique obtained 14 patients TURP divided into 2 groups. The control group was administered with analgesics and the treatment accepted analgesics and Benson relaxation. Data were analyzed using paired t-test and independent t-test. The results showed that administration of analgesics cannot reduce pain intensity (p 0.156), while the combination of Benson relaxation and analgesics can reduce pain intensity among TURP patients (p 0.002). Independent t-test confirmed that the combination therapy of relaxation Benson and analgesics can reduce pain intensity in patients TURP compared analgesic administer only (p 0.0170. The conclusion is the combination of Benson relaxation and analgesics can reduce pain intensity among TURP patients. Keyword: Pain intensity, Benson relaxation, transurethral resection of the prostate ABSTRAKTindakan pembedahan transurethral resection of the prostate (TURP) dapat menyebabkan nyeri dan trauma. Penggunaan terapi non-farmakologis dan farmakologis dapat digunakan untuk mengurangi intensitas nyeri pada pasien paska bedah. Relaksasi benson merupakan terapi non-farmakologis yang melibatkan faktor kepercayaan pasien untuk mencapai kondisi kesehatan dan kesejahteraan yang lebih tinggi. Tujuan dari penelitian ini yaitu untuk mengetahui efek relaksasi Benson terhadap intensitas nyeri pada pasien dengan TURP. Teknik total sampling medapatkan 14 pasien dengan tindakan TURP yang dibagi menjadi 2 kelompok. Kelompok kontrol diberikan analgesik dan kelompok perlakuan diberikan analgesik dan relaksasi benson. Analisis data menggunakan paired t-test dan independent t-test. Hasil penelitian menunjukkan pemberian analgesik tidak dapat mengurangi intensitas nyeri pada pasien TURP dengan nilai p 0,156, sedangkan kombinasi terapi relaksasi Benson dan analgesik dapat mengurangi intensitas nyeri pasien TURP dibandingkan dengan pemberian analgesik saja (p 0,017). Kesimpulannya terapi kombinasi relaksasi Benson dan pemberian analgesik dapat mengurangi intensitas nyeri pada pasien paska tindakan TURP. Kata Kunci: intensitas nyeri, relaksasi Benson, transurethral resection of the prostate

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Preventing chronic postoperative pain

Cited by 97 publications

References 69 publications

Effect of electroacupuncture on the cervicospinal P2X7 receptor/fractalkine/CX3CR1 signaling pathway in a rat neck-incision pain model

Effect of electroacupuncture on the cervicospinal P2X7 receptor/fractalkine/CX3CR1 signaling pathway in a rat neck-incision pain model

Association between pain sensitivity in the hand and outcomes after surgery in patients with lumbar disc herniation or spinal stenosis

Pengaruh Relaksasi Benson terhadap Penurunan Nyeri Paska Bedah pada Pasien <i>Transurethral Resection of the Prostate</i>.

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