Preventing contamination between injections with multiple-use nozzle needle-free injectors: A safety trial

Kelly, Kimberly A.; Loskutov, Anatoly; Zehrung, Darin; Puaa, Kapaakea; LaBarre, Paul; Muller, Nancy; Wang, Guiqiang; Ding, Huiguo; Hu, Da-rong; Blackwelder, William C.

doi:10.1016/j.vaccine.2007.12.041

Cited by 21 publications

(10 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, after injections with saline of volunteers who carried hepatitis B virus, 8% of subsequent injections into vials-representing the next vaccinees in a clinic or mass campaign-were found to contain hepatitis B antigen. 245 High-speed microcinematography also revealed extensive splash back from the skin during injection with MUNJIs.…”

Section: Solid Dissolving Needlesmentioning

confidence: 97%

Technologies to Improve Immunization

Papania¹,

Zehrung²,

Jarrahian³

2018

Plotkin's Vaccines

Self Cite

View full text Add to dashboard Cite

Section: Solid Dissolving Needlesmentioning

confidence: 97%

Technologies to Improve Immunization

Papania¹,

Zehrung²,

Jarrahian³

2018

Plotkin's Vaccines

Self Cite

View full text Add to dashboard Cite

“…The use of multidose systems with the same nozzle, occasionally lead to transmission of for example Hepatitis B between recipients. Studies demonstrated the infectious potential of several jet injectors [5,6]. Today, safe jet-injection systems are available using disposable parts facing the vaccinee.…”

Section: Needle-free (Intramuscular/subcutaneous) Jet Injectionmentioning

confidence: 99%

Alternative administration routes and delivery technologies for polio vaccines

Kraan

Stel

Kersten

et al. 2016

Expert Review of Vaccines

View full text Add to dashboard Cite

Global polio eradication is closer than ever. Replacement of the live attenuated oral poliovirus vaccine (OPV) by inactivated poliovirus vaccine (IPV) is recommended to achieve complete eradication. Limited global production capacity and relatively high IPV costs compared to OPV spur the need for improved polio vaccines. The target product profile of these vaccines includes not only dose sparing but also high stability, which is important for stockpiling, and easy application important for (emergency) vaccination campaigns. In this review, the current status of alternative polio vaccine delivery strategies is given. Furthermore, we discuss the feasibility of these strategies by highlighting challenges, hurdles to overcome, and formulation issues relevant for optimal vaccine delivery. ARTICLE HISTORY

show abstract

“…Jet injectors are devices that use pressure to deliver substances into the skin [48][49][50][51]. The first devices were multiple-use nozzle jet injectors, with which a large number of patient were vaccinated through the same fluid stream and nozzle [48,49]. However, such devices are no longer used because of cross-contamination.…”

Section: Jet Injectorsmentioning

confidence: 99%

Frontiers of transcutaneous vaccination systems: Novel technologies and devices for vaccine delivery

Matsuo

Hirobe

Okada

et al. 2013

Vaccine

View full text Add to dashboard Cite

Transcutaneous immunization (TCI) systems that use the skin's immune function are promising needle-free, easy-to-use, and low-invasive vaccination alternative to conventional, injectable vaccination methods. To develop effective TCI systems, it is essential to establish fundamental techniques and technologies that deliver antigenic proteins to antigen-presenting cells in the epidermis and dermis while overcoming the barrier function of the stratum corneum. In this review, we provide an outline of recent trends in the development of techniques for the delivery of antigenic proteins and of the technologies used to enhance TCI systems. We also introduce basic and clinical research involving our TCI systems that incorporate several original devices.

show abstract

Preventing contamination between injections with multiple-use nozzle needle-free injectors: A safety trial

Cited by 21 publications

References 9 publications

Technologies to Improve Immunization

Technologies to Improve Immunization

Alternative administration routes and delivery technologies for polio vaccines

Frontiers of transcutaneous vaccination systems: Novel technologies and devices for vaccine delivery

Contact Info

Product

Resources

About