Preventing Postpartum Venous Thromboembolism in 2022: A Narrative Review

Blondon, Marc; Skeith, Leslie

doi:10.3389/fcvm.2022.886416

Cited by 7 publications

(3 citation statements)

References 48 publications

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“…Cesarean delivery increases the risk of venous thromboembolism by three times compared with vaginal delivery [ 12 ]. During pregnancy, the women develop resistance to protein C, in addition to losing it through surgery [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Challenges in Cerebral Venous Thrombosis Management—Case Reports and Short Literature Review

Pleşa

Jijie²,

Toma³

et al. 2023

Life

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Cerebral venous thrombosis (CVT) is a rare type of stroke, with a complex clinical presentation that can make it a diagnostic challenge for the swift initiation of anticoagulation. When a hemorrhagic transformation is added, therapeutic management becomes even more complex. We describe a series of four cases, aged between 23 and 37 years old, with cerebral venous thrombosis. They were admitted to our clinic between 2014 and 2022. All cases presented significant challenges in either diagnostic, therapeutic or etiologic evaluation, at different stages of the disease. Late complications such as epilepsy or depression and other behavioral disorders represent long-term sequelae for the patient. Therefore, through its late complications, CVT is not only an acute disease but a chronic disorder with long-term follow-up requirements. The first case of the series is of a postpartum woman with focal neurological deficit caused by CVT with hemorrhagic transformation that presented multiple thrombotic complications and severe depression. The second case is of a man with extensive cerebral thrombosis who developed bilateral papillary edema under therapeutic anticoagulation treatment. The third case is of a woman with bilateral cavernous sinus thrombosis who later developed depressive disorder and focal seizures. The fourth case is of a pregnant woman in the first trimester presenting with a steep decline in consciousness level secondary to deep cerebral vein thrombosis requiring intensive care and subsequently developing a memory disorder. For a long period of time, due to being underdiagnosed, few things were known about CVT. Nowadays, we have all the tools to diagnose, treat, and follow up cases of CVT.

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Section: Discussionmentioning

confidence: 99%

Challenges in Cerebral Venous Thrombosis Management—Case Reports and Short Literature Review

Pleşa

Jijie²,

Toma³

et al. 2023

Life

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“…Zusammen mit weiteren Faktoren wie Geburtstraumata führt dies zu einem erhöhten Risiko für venöse Thrombembolien (VTE). Insgesamt sind schwangerschaftsassoziierte VTE 5-bis 10fach und innerhalb der ersten 6 Wochen postpartal sogar bis zu 22-bis 60-fach häufiger als VTE bei nicht schwangeren Frauen vergleichbaren Alters [10,11]. Die Inzidenz thrombembolischer Komplikationen liegt im Wochenbett bei ca.…”

Section: Herz Und Kreislaufunclassified

Wochenbett – evidenz- und eminenzbasierte Empfehlungen

Schneider¹,

Kehl²,

Beckmann³

et al. 2022

Frauenheilkunde up2date

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Die Postpartalphase des Wochenbetts ist charakterisiert durch Rückbildung der schwangerschaftsbedingten physiologischen Körperveränderungen. Sie wird durch Hebammen und Ärzte medizinisch überwacht und begleitet. So lassen sich Blutverlust, Wundheilung, der Beginn der Stillbeziehung und eventuell auftretende pathologische Prozesse durch Entzündungsvorgänge, Infektionen oder psychische Störungen rechtzeitig erkennen und behandeln.

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“…"Heparinassociated osteoporosis" and "heparin-induced thrombocytopenia (HIT)" are the chief maternal safety concerns that may be linked to the use of "unfractionated heparin (UFH)." This drug is commonly used for the treatment of VTE, which does not cross the placenta and does not result in fetal teratogenicity (Blondon & Skeith, 2022;Gates, Brocklehurst, & Davis, 2002;Greer, 2005;Huang, Li, Li, & Liao, 2022). Additionally, "activated partial thromboplastin time (APTT)" should be monitored when UFH is administered.…”

Section: Introductionmentioning

confidence: 99%

scoping review of venous thromboembolism and antithrombotic therapy in pregnancy

Ndjapa-Ndamkou

Govender

Chauke

et al. 2022

ijhs

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Introduction: Venous thromboembolism (VTE) is a known factor implicated in maternal mortality. Low molecular weight heparin (LMWH) and unfractionated heparin (UFH) are being widely used in cases of VTE. However, the efficiency of both of these drugs in the treatment of VTE is limited. Hence, a scoping review was conducted to understand the role of these drugs in the case of VTE. Methodology: The studies that included either the VTE or pulmonary embolism (PE) or both, and the studies that used the intervention of either the LMWH or UHF or both were selected. Case-control or cohort studies were included. The studies that were case-reports or with a sample of <10 were excluded. Results: Fifteen studies included 819 subjects with acute VTE. A total of 506 deep venous thrombosis (DVTs) and 127 PEs were reported in these studies. A total of 656 individuals received LMWH and 150 received UFH. There were 21 cases of antenatal bleeding and 259 cases of peri and post-delivery bleeding. UFH was given intravenously and subcutaneously in accordance with activated partial thromboplastin time results. Fifteen recurrent VTEs: four were DVTs and 11 were PEs (one death).

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Preventing Postpartum Venous Thromboembolism in 2022: A Narrative Review

Cited by 7 publications

References 48 publications

Challenges in Cerebral Venous Thrombosis Management—Case Reports and Short Literature Review

Challenges in Cerebral Venous Thrombosis Management—Case Reports and Short Literature Review

Wochenbett – evidenz- und eminenzbasierte Empfehlungen

scoping review of venous thromboembolism and antithrombotic therapy in pregnancy

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