Prevention and Control of Influenza by Chemoprophylaxis and Chemotherapy

Jackson, George Gee

doi:10.1001/jama.1976.03260510033021

Cited by 25 publications

(1 citation statement)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may be due in part to concern regarding reported central nervous system side effects, such as inability to concentrate, insomnia, and nervousness, which are usually infrequent and minimal (3,7,10,11). Rimantadine, an analog of amantadine, has been shown to have similar antiviral efficacy but reportedly fewer side effects ( 483,1978).…”

mentioning

confidence: 99%

Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine

Millet¹,

Dreisbach²,

Bryson³

1982

Antimicrob Agents Chemother

View full text Add to dashboard Cite

A total of 52 healthy, adult volunteers were randomly assigned to five treatment groups to be treated twice daily for 4 days with 100 mg of amantadine, 100 mg of rimantadine, 4 mg of chlorpheniramine or placebo alone, or 100 mg of amantadine in combination with chlorpheniramine. The results of tests measuring performance on tasks of attention, reasoning, and memory were unaffected by treatment. Subjective side effects in recipients of amantadine, rimantadine, and chlorpheniramine were comparable and minimal. Side effects appeared to be enhanced in subjects receiving both amantadine and chlorpheniramine.

show abstract

mentioning

confidence: 99%

Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine

Millet¹,

Dreisbach²,

Bryson³

1982

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

Influenza: Vaccines or Amantadine?

Chanin¹

1977

JAMA

View full text Add to dashboard Cite

Prevention of Russian Influenza by Amantadine

Monto¹

1979

JAMA

104

View full text Add to dashboard Cite

We tested the effectiveness of amantadine hydrochloride in prevention of illness and infection caused by Russian (h1n1) influenza. The trial lasted seven weeks and was double-blind and placebo controlled. The dosage used was 200 mg daily. Efficacy in prevention of serologically confirmed clinical influenza was 70.7%. Efficacy in prevention of infection, symptomatic or asymptomatic, was 39.4%. Side effects seen were all mild, began within two days of the start of the trial, and terminated rapidly on cessation of prophylaxis. The withdrawal rate attributable to use of amantadine was 6.2%. Those who continued to receive prophylaxis for the remainder of the trial did not exhibit excess side effects. It is concluded that amantadine is safe and effective in prophylaxis of H1N1 strains, as has been shown previously for other subtypes of A influenza.

show abstract

Prevention and Control of Influenza by Chemoprophylaxis and Chemotherapy

Cited by 25 publications

References 34 publications

Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine

Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine

Influenza: Vaccines or Amantadine?

Prevention of Russian Influenza by Amantadine

Contact Info

Product

Resources

About