Prevention and Treatment of Alzheimer Disease and Aging: Antioxidants

Liu, Quan; Xie, Fang; Rolston, Raj K.; Moreira, Paula I.; Nunomura, Akihiko; Zhu, Xiongwei; Smith, Mark A.; Perry, George

doi:10.2174/138955707779802552

Cited by 62 publications

(33 citation statements)

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“…Of note, an early-stage involvement of neuronal RNA oxidation is not only evident in age-associated neurodegenerative diseases, but also in cases with subacute sclerosing panencephalitis that is caused by persistent measles virus infection in the CNS and is pathologically accompanied with brain atrophy and neurofibrillary tangles [43]. From a clinical perspective, the notion of an early involvement of oxidative damage in the pathogenesis of these degenerative diseases should have a great importance to the establishment of diagnostic tools and therapeutic targets, as we have reviewed recently [9,78,79].…”

Section: Rna Oxidation: An Early-stage Event In the Process Of Neurodmentioning

confidence: 99%

Oxidative RNA Damage and Neurodegeneration

Nunomura¹,

Moreira

Takeda³

et al. 2007

CMC

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Section: Rna Oxidation: An Early-stage Event In the Process Of Neurodmentioning

confidence: 99%

Oxidative RNA Damage and Neurodegeneration

Nunomura¹,

Moreira

Takeda³

et al. 2007

CMC

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“…There is growing experimental evidence of the possible role of α-tocopherol in oxidative stress-related diseases including neurological conditions such as Alzheimer's, Parkinson's and Down's syndrome (Schrag et al, 2013;Sung et al, 2004;Buhmann et al, 2004;Liu et al, 2007;Perrone et al, 2007). Ascorbic acid (Vitamin C) is known to play a crucial role in immune system function (Maggini et al, 2007;Webb and Villamor, 2007) and amino acid metabolism.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Micronutrients in Fenugreek (Trigonella foenum-graecum L.): A Viable Alternative for Micronutrient Supplementation

Pant¹,

Tewari²,

Dhoundiyal³

et al. 2018

Int.J.Curr.Microbiol.App.Sci

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Journal homepage: http://www.ijcmas.com Dietary antioxidants (total ascorbate, α-tocopherol and total carotenoids) and micronutrient (iron, calcium, zinc, copper and manganese) content of 25 fenugreek (Trigonella foenum graecum L.) genotypes were evaluated under the present investigation. Higher α-tocopherol and total carotenoid content i.e., 43.080±1.542 mg α-tocopherol/100 g dry wt. and 4.890±0.047 g carotenoids/100 g dry wt. was observed in RMt-305. The genotype RMt-143 showed highest iron, calcium and manganese content i.e., 184.11±1.639, 781.20±4.790 and 25.65±0.695 µg/g dry wt., respectively. Total ascorbate content within fenugreek genotypes under investigation showed a positive correlation with α-tocopherol and total carotenoid content (i.e., 0.114 and 0.061, respectively). It also showed a significant (p≤0.05) positive correlation with manganese (0.298) and iron content (0.062) among the genotypes. α-tocopherol content within fenugreek genotypes also showed a significant (p≤0.01) positive correlation (0.328) with total carotenoid content another important lipid-soluble antioxidant. The iron content within the fenugreek genotypes showed a significant (p≤0.01) positive correlation with other micronutrients viz., calcium, zinc and manganese (i.e., 0.408, 0.502 and 0.299, respectively). A positive correlation was also observed between iron and total ascorbate, α-tocopherol content (i.e., 0.062 and 0.213, respectively) within the genotypes. Similarly other mineral elements viz., calcium, zinc, copper and manganese, respectively also showed a positive correlation with each other in general. The findings of the present investigation clearly show significant variation in dietary antioxidants and micronutrients among the fenugreek genotypes under investigation. Thus the genotypes with higher dietary antioxidants and micronutrient content viz., RMt-305, Pant ragini, RMt-143, Pusa early bunching, IC-066843, GM-2 and HM-355 could be utilized as a valuable source of dietary micronutrients and may serve as potential functional food to combact micronutrient malnutrition along with other favourable health promoting affect. K e y w o r d sAscorbate, α-Tocopherol, Carotenoid, Dietary antioxidants, Micronutrients

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“…The membrane of all aerobic organisms are susceptible to damage by reactive oxygen species (ROS) which consists of free radicals (FRs) (Aruoma, 1998). Because of their reactivity, ROS have been implicated in pathologic processes such as carcinogenesis, inflammation, aging, and radiation damage among others (Liu et al, 2007). An overabundance of FRs in the cells may lead to uncontrolled chain reactions with polyunsaturated fatty acids in cell membranes which ultimately lead to lipid peroxidation (LPO).…”

Section: Introductionmentioning

confidence: 99%

Gamma radiation effects in the brain of rats: antioxidant and radioprotective properties of <i>Vernonia amygdalina</i> leaf extract

Owoeye¹,

Adesida²,

Onwuka³

et al. 2011

International Journal of Biological and Chemical Sciences

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Radiotherapy side effects have been attributed to free radical reactions. This study evaluated the antioxidant activity of the methanolic extract of V. amygdalina (MEVA) against gamma irradiation-induced oxidative stress in rats' brain. Seventy male rats weighing 130-160 g were randomized into seven groups, with each group comprising ten rats namely: control, MEVA at 250, and 500 mg/kg/day, radiation only, radiation plus MEVA at 250, and 500 mg/kg/day, and alpha-tocopherol (TOCO). Rats were treated for 14 days, irradiated on the 15 th day, and euthanized on the 16 th day. Bioassays of malondialdehyde for lipid peroxidation (LPO), reduced glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) were carried out using standard techniques. Some of the brains were processed for paraffin wax embedment and stained with haematoxylin and eosin. Data were analyzed using ANOVA. Radiation caused a significant (p<0.01) elevation in LPO by about 142%. Pretreatment with 250 mg MEVA, 500 mg MEVA and TOCO reduced LPO significantly (p<0.01) by 56%, 65%, and 80% respectively, when compared with rats that received gamma radiation only. There was improvement in the histological alterations in the cerebellar layers and the Purkinje cell parameters of the pretreated groups when compared with the gamma-irradiated (R) group. MEVA demonstrated antioxidant and radioprotective effects in rats' brain.

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Prevention and Treatment of Alzheimer Disease and Aging: Antioxidants

Cited by 62 publications

References 0 publications

Oxidative RNA Damage and Neurodegeneration

Oxidative RNA Damage and Neurodegeneration

Evaluation of Micronutrients in Fenugreek (Trigonella foenum-graecum L.): A Viable Alternative for Micronutrient Supplementation

Gamma radiation effects in the brain of rats: antioxidant and radioprotective properties of <i>Vernonia amygdalina</i> leaf extract

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