Prevention and treatment of Candida colonization on denture liners: A systematic review

Skupien, Jovito Adiel; Valentini, Fernanda Danieli Antoniazzi; Boscato, Noéli; Pereira‐Cenci, Tatiana

doi:10.1016/j.prosdent.2013.07.003

Cited by 112 publications

(94 citation statements)

References 60 publications

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“…For example, Nystatin and silver-based antimicrobial agents have been demonstrated to inhibit Candida growth 13,14) . However, indication for these antimicrobials is limited to patients with xerostomia with movement disorders, because there is a risk of developing resistant bacteria 15) . Thus, they have not been widely used in the clinical setting.…”

Section: Introductionmentioning

confidence: 99%

Effect of incorporation of surface pre-reacted glass ionomer filler in tissue conditioner on the inhibition of Candida albicans adhesion

et al. 2018

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We investigated the effects of incorporation of surface pre-reacted glass ionomer (S-PRG) filler in tissue conditioner (TC) on Candida albicans adhesion. We prepared specimens containing 0, 5, 10, or 20 wt% of S-PRG filler, and measured the amount of C. albicans on the surface using a colony forming unit (CFU) assay and scanning electron microscopic images. In addition, we measured the consistency, penetration depth, and surface roughness (Ra). CFU values for 10 and 20 wt% were significantly lower than that for the control (p<0.05). Hyphal density on the surface was greater in the control. The 10 and 20 wt% specimens showed significantly higher consistency and Ra, lower penetration depth ratio than control (p<0.05). These results suggest that incorporation of S-PRG filler may reduce C. albicans adhesion onto TC surface; however, the optimal amount of filler is dictated by the influence of filler incorporation on mechanical and surface characters of TC.

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Section: Introductionmentioning

confidence: 99%

Effect of incorporation of surface pre-reacted glass ionomer filler in tissue conditioner on the inhibition of Candida albicans adhesion

et al. 2018

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“…37,38 Nystatin was shown to be as effective as a Candida growth inhibitor, but no consensus was reached on the best concentration of nystatin. 22 The present study found that 300,000 U was the most effective concentration of nystatin, therefore nystatin may be a good choice to prevent colonization of Candida albicans on soft liners. Because of the usage times of this type soft liners vary between a few weeks and a few months, we think that nystatin addition will extend the maximum usage period.…”

mentioning

confidence: 50%

“…Several investigations showed that the antimicrobial effect of nystatin supplemented tissue conditioners 19,20 and soft denture liners. 21,22 …”

Section: Introductionmentioning

confidence: 99%

Comparison of the Effect of Nystatin and Titanium Dioxide Addition on Candida Colonization in Soft Lining Material

Bayındır¹,

Aktaş²,

Baştopçu³

2017

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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Material and methods. Disks of Ufi Gel P and Mollosil cold-curing, soft relining materials with a diameter of 5 mm and thickness of 2 mm were prepared with nystatin and TiO 2 powders in a concentration of 5%, 10%, and 15% (w/v). For the control group, only discs not containing nystatin and TiO 2 were prepared, which consisted only of soft lining material. C. albicans was inoculated on Sabouraud dextrose agar (SDA)-coated plates. The disks were placed on these plates and incubated aerobically at 37° C.The Ufi Gel P and Mollosil disks, including 10% w/v nystatin, (re-prepared for the second step of the study) were immersed in water for separate intervals (1, 7, 14, and 16 days) to determine the fungicidal action over time. The disks were then removed and placed on SDA plates inoculated with C. albicans. In each group, one control disk without nystatin or TiO 2 was included. Results.A univariate analysis of variance test revealed that the activity of C. albicans was not significantly inhibited on the control disks (p < 0.001). The addition of nystatin in powder form to the soft liners prevented the colonization of C. albicans in vitro. The immersion time of the disks plunged in water appeared to affect the degree of inhibition. However, the addition of TiO 2 did not prevent colonization by C. albicans of the soft liners.Conclusions. This study showed that the addition of nystatin in powder form to soft liners prevented the colonization of C. albicans in vitro but that the addition of the same amount of TiO 2 powder did not.

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“…Polyene agents such as nystatin and amphotericin are remedial treatments for primary oral candidosis (1,9,11). Nystatin binds to ergosterol within the cell membrane of Candida and creates pores in the fungal cell membrane, resulting in leakage of fungal cell contents and potassium ions, which results in cell death (7,12,13). Polyenes are not absorbed from the gastrointestinal tract, and drug-induced resistance is extremely rare (9,12).…”

Section: Introductionmentioning

confidence: 99%

In vivo study of antifungal effects of low-molecular-weight chitosan against Candida albicans

Atai

Amini

et al. 2017

Journal of Oral Science

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This study investigated the antifungal effects of low-molecular-weight chitosan solution onCandida albicans in denture stomatitis in comparison with nystatin suspension. This randomized, singleblind clinical trial included 40 patients diagnosed with denture stomatitis. Patients were divided into two groups, wherein one was treated with chitosan and the other with nystatin for 2 weeks. Changes in the erythematous area were recorded during and after treatment. A palatal smear was obtained for each patient before and after treatment to determine the number of blastospores and mycelia of C. albicans. The results were compared using the MannWhitney U test, revealing that the chitosan solution significantly decreased the erythematous surface area, burning sensation, time required for clinical improvement, and number of blastospores and mycelia. The antifungal efficacy of chitosan along with its inherent biocompatibility makes it a promising candidate for use as an antifungal mouthwash.

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Prevention and treatment of Candida colonization on denture liners: A systematic review

Cited by 112 publications

References 60 publications

Effect of incorporation of surface pre-reacted glass ionomer filler in tissue conditioner on the inhibition of <i>Candida albicans</i> adhesion

Effect of incorporation of surface pre-reacted glass ionomer filler in tissue conditioner on the inhibition of <i>Candida albicans</i> adhesion

Comparison of the Effect of Nystatin and Titanium Dioxide Addition on Candida Colonization in Soft Lining Material

<i>In vivo</i> study of antifungal effects of low-molecular-weight chitosan against <i>Candida albicans </i>

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