Prevention and Treatment of Methotrexate-induced Hepatotoxicity: Potential of Natural Phytobioactive Compounds<strong> </strong>

Abstract

Methotrexate (MTX) is a potent drug for the treatment of various diseases globally amidst being a chemotherapeutic and immunosuppressant agent. However, hepatotoxicity induced by MTX could be life-threatening if left untreated. Folate supplementation is concurrently applied to reduce the adverse effects of MTX, albeit efficacy compromise. Therefore, there is the need to understand the process for the prevention and treatment strategies for MTX induced hepatotoxicity (MIH). In recent times, preliminary preclinical and clinical findings indicate the potential of natural phytobioactive compounds for MIH prevention and treatment. This mini review therefore summarizes proposed mechanisms of MIH and recent advances in the prevention and treatment prospects of natural phytobioactive compounds on MIH.

Andrographis paniculata (Burm.f.) Nees Alleviates Methotrexate-Induced Hepatotoxicity in Wistar Albino Rats

“…Furthermore, it has been demonstrated that TNF-α is Life 2023, 13, 1173 2 of 15 crucial for maintaining liver equilibrium and links inflammation to apoptosis. According to previous studies, elevated levels of TNF-α, IL-6, and other cytokines trigger apoptotic pathways resulting in methotrexate-induced hepatotoxicity [13,14]. MTX is reported to cause hepatotoxicity when used for a prolonged period, even at a minimal dosage [15].…”