Prevention by Rutin of gastric lesions induced by ethanol in rats: role of endogenous prostaglandins

Pérez‐Guerrero, Concepción; Martín, Maria J.; Marhuenda, E.

doi:10.1016/0306-3623(94)90217-8

Cited by 21 publications

(10 citation statements)

References 31 publications

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“…The results of this study showed that the seed extract of P. cupana prevents gastric damage caused by ethanol and indomethacin, the most commonly utilized experimental models in the evaluation of antiulcer activity in rats (Robert et al, 1979;Kapui et al, 1993). Phytochemical analysis showed that guarana extract contains flavonoids and caffeine, substances that have proven antiulcer activity (Pêrez Guerrero et al, 1994;Rao et al, 1997). Caffeine, the trimethylxanthine has previously been shown to possess gastroprotective property against acute gastic injury induced by ethanol and ibuprofen (Koyama et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Guarana (Paullinia cupana Mart.) offers protection against gastric lesions induced by ethanol and indomethacin in rats

Campos

Barros

Santos

et al. 2003

Phytotherapy Research

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The effects of guarana (Paullinia cupana) extract were analyzed in rats on acute gastric lesions induced by ethanol and indomethacin and were compared to those produced by caffeine, a methylxanthine. Guarana (50 and 100 mg/kg p.o.) pretreated animals showed a significant reduction in the severity of gastric lesions induced by absolute ethanol in a manner similar to caffeine (20 and 30 mg/kg p.o.). Against indomethacin-induced gastric ulceration, guarana at a higher dose offered significant protection but caffeine was ineffective at the doses tested. In 4 h pylorus-ligated rats, both guarana and caffeine caused significant diminution in the gastric secretory volume as well as the total acidity. Gastrointestinal transit in mice was not significantly affected by either of these agents. These findings indicate that guarana has a gastroprotective property that needs further elucidation as regards to its mechanism.

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Section: Discussionmentioning

confidence: 99%

Guarana (Paullinia cupana Mart.) offers protection against gastric lesions induced by ethanol and indomethacin in rats

Campos

Barros

Santos

et al. 2003

Phytotherapy Research

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show abstract

“…EBM which showed good protection against ulcers in aspirin-pylorus ligated model lagged in this model and just produced 48.21% ulcer protection. This may be hypothesized that rutin protects against aspirin-pylorus ligation induced gastric ulcers, does not modify the endogenous PGs disturbed due to the ethanol administration (Guerrero et al, 1994). But kaempferol-3-O-β-glucopyranoside was found to improve the cytoprotection against HCl-ethanol induced ulcers by altering the gastric mucosa (Yesilada & Gurbuz, 2010).…”

Section: Discussionmentioning

confidence: 99%

Role ofBlepharis maderaspatensisandAmmannia bacciferaplant extracts onin vitrooxygen radical scavenging, secretion of gastric fluid and gastroprotection on ulcer induced rats

Rajasekaran¹,

Sivakumar

Darlinquine

2012

Pharmaceutical Biology

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“…Moreover, it has been indicated that rutin can inhibit I/R-induced myocardial apoptosis and has a cardioprotective effect in rats (Ali et al, 2009). Previous studies also showed that rutin can affect the relaxation of mouse isolated stomach (Amira et al, 2008) and has a protective effect against stress-or ethanol-induced gastric mucosal lesions (Barnaulow et al, 1983;Pérez Guerrero et al, 1994). Furthermore, rutin is commonly present in many plants, especially buckwheat, onions, apples, tea and red wine (Hertog et al, 1993).…”

Section: Introductionmentioning

confidence: 97%

Protective effect of rutin against acute gastric mucosal lesions induced by ischemia-reperfusion

Liu

Gou

et al. 2013

Pharmaceutical Biology

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Context: Rutin, a flavonoid commonly present in onions, apples and tea, has been suggested to have a variety of pharmacological activities, including immunomodulator, anti-inflammatory and antioxidant activities. Objectives: The present study was to examine the protective effects of rutin on gastric mucosal damage induced by gastric ischemia-reperfusion (I/R) in rats. Materials and methods: Rutin (50, 100, 200 mg/kg) was administered intragastrically for five consecutive days before ischemia. Sixty minutes after the last administration of rutin, under anesthesia, the celiac artery was clamped for 30 min, and then the clamp was removed for 60 min reperfusion. After reperfusion, the stomach was removed for biochemical and histological examinations. Results: As compared with the I/R group (116.7 AE 21.5), administration of rutin at doses of 50, 100 and 200 mg/kg significantly prevented the increase of gastric mucosal injury index induced by gastric I/R (73.4 AE 14.8, 65.9 AE 9.6 and 26.9 AE 5.7, respectively). ED 50 value was 138.7 mg/kg. Moreover, rutin at doses of 50, 100 and 200 mg/kg showed an inhibition on the increased myeloperoxidase (24.6, 41.3 and 53.1% reduction) activity and malondialdehyde levels (27.4, 40.3 and 50.7% reduction) in gastric mucosa. Also, the elevation of inducible NO synthase (iNOS) activity as well as the decrease of constitutive NO synthase (cNOS) in the gastric mucosa were significantly prevented by rutin pretreatment. Conclusion: These results suggested that rutin has a protective effect against gastric mucosal injury induced by gastric I/R and that the gastroprotection was related to the NOS/NO pathway and its antioxidant activity.

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Prevention by Rutin of gastric lesions induced by ethanol in rats: role of endogenous prostaglandins

Cited by 21 publications

References 31 publications

Guarana (Paullinia cupana Mart.) offers protection against gastric lesions induced by ethanol and indomethacin in rats

Guarana (Paullinia cupana Mart.) offers protection against gastric lesions induced by ethanol and indomethacin in rats

Role ofBlepharis maderaspatensisandAmmannia bacciferaplant extracts onin vitrooxygen radical scavenging, secretion of gastric fluid and gastroprotection on ulcer induced rats

Protective effect of rutin against acute gastric mucosal lesions induced by ischemia-reperfusion

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