Prevention of acute cadmium toxicity by Picroliv

Yadav, Neelam; Dogra, R.K.S.; Khan, M. Y.; Khandelwal, Shashi

doi:10.1191/0960327105ht563oa

Cited by 17 publications

(8 citation statements)

References 25 publications

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“…Protection against acute and chronic Cd toxicity by reducing oxidative stress has been reported by many groups (Sunitha et al 2001;Khandelwal et al 2002;Shaikh and Tang 2002;Ray et al 2002;Yadav et al 2005). Similarly in our studies, antioxidant property could be one of the main triggering factors, responsible for mitigation of all downstream events initiating with ROS and GSH preceding mitochondrial membrane potential, caspase-3 activation followed by DNA damage and phenotypic alterations at 18 h and blastogenesis and cytokine release at a much later stage.…”

Section: Discussionsupporting

confidence: 70%

“…Curcumin treatment also prevented the GSH oxidation and maintained GSH/GSSH ratio in rats after oral administration of CCl 4 (Reyes- Gordillo et al 2007). Yadav et al (2005) and Yadav and Khandelwal (2008) have reported the antioxidative potential of picroliv in liver and testis of rats against cadmium. Cadmium induced enhanced lipid peroxidation, membrane fluidity and reduced levels of nonprotein sulphydryls and Na + K + ATPase were significantly restored by picroliv.…”

Section: Discussionmentioning

confidence: 97%

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Comparative efficacy of piperine, curcumin and picroliv against Cd immunotoxicity in mice

Pathak

Khandelwal

2008

Biometals

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Cadmium (Cd), a well known environmental carcinogen, is a potent immunotoxicant. In rodents, it is primarily characterized by marked thymic atrophy and splenomegaly. Cadmium induces apoptosis in murine lymphocytes and alters the immune functions. Thus, for the amelioration of its effect, three structurally different bioactive herbal extracts such as piperine-alkaloid, picroliv-glycosides and curcumin-polyphenols were evaluated and their efficacy compared. For ascertaining their immunomodulatory role, various biochemical indices of cell damage such as cytotoxicity, oxidative stress (ROS, GSH), apoptosis (mitochondrial membrane potential, caspase-3 activity, phosphatidylserine externalization, apoptotic DNA) along with lymphocyte phenotyping, blastogenesis and cytokine secretion were assessed in thymic and splenic cell suspensions. Of the three herbals examined, piperine displayed maximum efficacy. All the three doses of piperine (1, 10 and 50 microg/ml) increased cell viability in a dose dependent manner, whereas curcumin and picroliv were also effective, but to a lesser degree. Only the two higher doses exhibited cell viability efficacy. The median doses ie 10 microg/ml, were therefore selected, for comparison of their antioxidant, anti-apoptotic and immune function modulation. Restoration of ROS and GSH was most prominent with piperine. The anti-apoptotic potential was directly proportional to their antioxidant nature. In addition, Cd altered blastogenesis, T and B cell phenotypes and cytokine release were also mitigated best with piperine. The ameliorative potential was in order of piperine > curcumin > picroliv and former could be considered the drug of choice under immunocompromised conditions.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 97%

Comparative efficacy of piperine, curcumin and picroliv against Cd immunotoxicity in mice

Pathak

Khandelwal

2008

Biometals

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“…Recently, some phytochemicals and plant extracts with antioxidative properties have been found to have the capacity to decrease tissue cadmium levels and cadmium-induced oxidative stress (15)(16)(17)(18). Such natural compounds have few side effects, and some of them can be served as dietary nutritional ingredients.…”

mentioning

confidence: 99%

Protective Effects of Lactobacillus plantarum CCFM8610 against Acute Cadmium Toxicity in Mice

Zhai

Wang

Zhao

et al. 2013

Appl Environ Microbiol

174

113

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bThis study evaluated the protective effects of Lactobacillus plantarum CCFM8610, a selected probiotic with good cadmium binding capacity, against acute cadmium toxicity in mice. Ninety mice were divided into prevention and therapy groups. In the prevention groups, CCFM8610 was administered at 10 9 CFU once daily for 7 days, followed by a single oral dose of cadmium chloride at 1.8 mg cadmium for each mouse. In the therapy groups, the same dose of CCFM8610 was administered for 2 days after an identical single dose of cadmium exposure. Mice that received neither cadmium nor culture or that received cadmium alone served as negative and positive controls, respectively. The effects of both living and dead CCFM8610 on cadmium ion concentrations in feces, liver, and kidney were determined. Moreover, the alterations in reduced glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and histopathology in the liver and kidney were investigated. The results showed that compared to the mice that received cadmium only, CCFM8610 treatment can effectively decrease intestinal cadmium absorption, reduce tissue cadmium accumulation, alleviate renal and hepatic oxidative stress, and ameliorate hepatic histopathological changes. Living CCFM8610 administered after cadmium exposure offered the most significant protection. Our results suggested that CCFM8610 is more effective against acute cadmium toxicity than a simple antioxidant treatment due to its special physiological functions and that it can be considered a new dietary therapeutic strategy against acute cadmium toxicity.

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“…The supplementation of vanaspati with ferrous sulfate resulted in an elevated activity of ALP. The results are in accordance with those of Demerdesh et al .,[ 11 ] Kara et al ,[ 12 ] and Yadav et al .,[ 13 ] who reported an increase in the activities of ALT and ALP in plasma following cadmium toxicity.…”

Section: Resultsmentioning

confidence: 99%

Effect of dietary vanaspati alone and in combination with stressors on sero-biochemical profile and immunity in white leghorn layers

Raj¹,

Reddy²,

Reddy³

et al. 2011

Toxicol Int

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A total of 160 White Leghorns of 20 wk age were divided randomly into eight groups. Groups 1, 3, 4 and 5 were fed basal feed and the rest were fed 5% vanaspati supplemented feed until 42 wk of age. From 42 to 54 wk, groups 3, 4 and 5 were fed 1% ferrous sulfate, 100 ppm chlorpyrifos (CPS) and 100 ppm cadmium, respectively, along with basal feed and groups 6, 7 and 8 were fed similar stressors, respectively, along with 5% vanaspati. Groups 1 and 2 served as controls for basal feed and 5% vanaspati feed. Alkaline phosphatase (ALP), alanine transaminase (ALT), total protein, albumin, globulin, A/G ratio, total cholesterol, high density cholesterol (HDL), triglycerides, creatinine, hemagglutination inhibition (HI) titer, and phytohemagglutination (PHA) index were studied. Supplementation of vanaspati resulted in a significant reduction in PHA, cholesterol, albumin and HI titer. Cadmium significantly increased ALP, AST, creatinine and paradoxically increased HDL cholesterol and HI titers. Vanaspati along with cadmium showed similar effects. Administration of CPS lowered PHA index, whereas supplementation along with vanaspati decreased the HI titers and increased the PHA index. Supplementation of vanaspati alone and in combination revealed harmful effects and aggravated the toxicities of CPS and cadmium. Hence, it is concluded that consumption of vanaspati could be harmful.

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Prevention of acute cadmium toxicity by Picroliv

Cited by 17 publications

References 25 publications

Comparative efficacy of piperine, curcumin and picroliv against Cd immunotoxicity in mice

Comparative efficacy of piperine, curcumin and picroliv against Cd immunotoxicity in mice

Protective Effects of Lactobacillus plantarum CCFM8610 against Acute Cadmium Toxicity in Mice

Effect of dietary vanaspati alone and in combination with stressors on sero-biochemical profile and immunity in white leghorn layers

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