Prevention of adhesions to polypropylene mesh in a traumatized bowel model2 2

Dinsmore, Robert C.; Calton, William C.; Harvey, Stephen B.; Blaney, Michael W

doi:10.1016/s1072-7515(00)00337-9

Cited by 72 publications

(13 citation statements)

References 5 publications

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“…The polypropylene, the most used mesh currently is a synthetic material that produces little tissue reaction and has good tensile strength, resistance that this is maintained for several years after its use in living organisms 6 .…”

Section: Introductionmentioning

confidence: 99%

Effects of nitrofurazone on correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Effects of nitrofurazone on correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue

et al. 2015

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“…Recent studies showed that not only the foreign material or making of mesh but also the impairment of visceral peritoneum is a co-decisive factor for the development of intestine-to-mesh adhesions 18, 25, 26. This especially accounts for areas where intestine has been dissected from the hernia sac.…”

Section: Discussionmentioning

confidence: 99%

Adhesion Prevention Efficacy of Composite Meshes Parietex^®, Proceed^® and 4DryField^® PH Covered Polypropylene Meshes in an IPOM Rat Model

Winny¹,

Maegel²,

Grethe³

et al. 2016

Int. J. Med. Sci.

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Background: Adhesions to intraperitoneally implanted meshes (IPOM) are a common problem following hernia surgery and may cause severe complications. Recently, we showed that missing peritoneal coverage of the intestine is a decisive factor for adhesion formation and 4DryField® PH (4DF) gel significantly prevents intestine-to-mesh adhesions even with use of uncoated Ultrapro® polypropylene mesh (UPM). The present study investigates adhesion prevention capability of coated Parietex® mesh (PTM) and Proceed® mesh (PCM) in comparison to 4DF treated UPM.Methods: 20 rats were randomized into two groups. A 1.5 x 2 cm patch of PTM or PCM was attached to the abdominal wall and the cecum was depleted from peritoneum by abrasion. After seven days incidence of intestine-to-mesh adhesions was evaluated using Lauder and Hoffmann adhesion scores. Histological specimens were evaluated; statistics were performed using student's t-test. The data were compared with recently published data of 4DF treated uncoated UPM.Results: Use of PTM or PCM did not significantly diminish development of intestine-to-mesh adhesions (adhesion reduction rate PTM: 29%, p = 0.069 and PCM: 25%, p = 0.078). Histological results confirmed macroscopic finding of agglutination of intestine and abdominal wall with the mesh in between. Compared to these data, the use of UPM combined with 4DF gel reveals significantly better adhesion prevention capability (p < 0.0001) as shown in earlier studies. However, in clinical situation interindividual differences in adhesion induction mechanisms cannot be excluded by this experimental approach as healing responses towards the different materials might vary.Conclusion: This study shows that in case of impaired intestinal peritoneum coated PTM and PCM do not provide significant adhesion prevention. In contrast, use of UPM combined with 4DF gel achieved a significant reduction of adhesions. Hence, in case of injury of the visceral peritoneum, application of a polysaccharide barrier device such as 4DF gel might be considered more effective in reducing intestine-to-mesh adhesions than coated mesh devices.

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“…Indeed, pelvic dead space is related to a high rate of local complications, especially local infections, pelvic organs herniation, bowel loops prolapse and obstruction (Chiantera et al, 2014, Kolehmainen et al, 2013, Dinsmore et al, 2000, Bondioli et al, 2014, Silverman, 2011, Said et al, 2007, Momoh et al, 2010, Altman et al, 2008, Komatsu et al, 2013, Magrina et al, 1997, Rowland et al, 1987, Coleman, 1995, Dindo et al, 2004, Croak et al, 2004). These adverse events significantly compromise patient's quality of life and sometimes require a second aggressive surgical intervention.…”

Section: Discussionmentioning

confidence: 99%

“…Synthetic mesh used for pelvic reconstruction, despite increased mechanical support, attempts to adhesions and other relevant complications (Dinsmore et al, 2000). Primary reconstructive myocutaneous flap (MF) from abdomen or thigh is invasive and sometimes it cannot be performed because of previous incisions, hernia or insufficient flap tissue volume that compromise the donor site.…”

Section: Introductionmentioning

confidence: 99%

A surgical multi-layer technique for pelvic reconstruction after total exenteration using a combination of pedicled omental flap, human acellular dermal matrix and autologous adipose derived cells

Perrone

Livi

Fini

et al. 2016

Gynecologic Oncology Reports

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Prevention of adhesions to polypropylene mesh in a traumatized bowel model2 2

Cited by 72 publications

References 5 publications

Effects of nitrofurazone on correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue

Effects of nitrofurazone on correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue

Adhesion Prevention Efficacy of Composite Meshes Parietex^®, Proceed^® and 4DryField^® PH Covered Polypropylene Meshes in an IPOM Rat Model

A surgical multi-layer technique for pelvic reconstruction after total exenteration using a combination of pedicled omental flap, human acellular dermal matrix and autologous adipose derived cells

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Prevention of adhesions to polypropylene mesh in a traumatized bowel model2 2

Cited by 72 publications

References 5 publications

Effects of nitrofurazone on correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue

Effects of nitrofurazone on correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue

Adhesion Prevention Efficacy of Composite Meshes Parietex®, Proceed® and 4DryField® PH Covered Polypropylene Meshes in an IPOM Rat Model

A surgical multi-layer technique for pelvic reconstruction after total exenteration using a combination of pedicled omental flap, human acellular dermal matrix and autologous adipose derived cells

Contact Info

Product

Resources

About

Adhesion Prevention Efficacy of Composite Meshes Parietex^®, Proceed^® and 4DryField^® PH Covered Polypropylene Meshes in an IPOM Rat Model