Prevention of Alveolar Air Leakage after Video-Assisted Thoracic Surgery: Comparison of the Efficacy of Methods Involving the Use of Fibrin Glue

Kawai, Hideki; Harada, Kenji; Ohta, Hiroyuki; Tokushima, Takeshi; Oka, Shiro

doi:10.1055/s-0031-1293599

Cited by 37 publications

(23 citation statements)

References 13 publications

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“…Statistically significant improvement in duration of pleural drainage (2.7 ± 1.55 versus 4.2 ± 2.10 days, P < 0.01) as well as incidence of prolonged (>1 week) air leak (0 versus 14 {6.6%} patients, P < 0.01) was found using the second method. A second group of investigators [167] performed a similar study in 126 consecutive video assisted thoracic surgery patients (VATS) using three different application methods of fibrin sealant and PGA sheets. They found that rubbing fibrinogen into the defect area followed by application of a PGA sheet sprayed with fibrin sealant (as compared to two other methods) had the best success at preventing postoperative air leakage ( P < 0.05).…”

Section: Most Frequent Fibrin Sealant Clinical Literature Applicatmentioning

confidence: 99%

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

2014

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Background. Fibrin sealant became the first modern era material approved as a hemostat in the United States in 1998. It is the only agent presently approved as a hemostat, sealant, and adhesive by the Food and Drug Administration (FDA). The product is now supplied as patches in addition to the original liquid formulations. Both laboratory and clinical uses of fibrin sealant continue to grow. The new literature on this material also continues to proliferate rapidly (approximately 200 papers/year). Methods. An overview of current fibrin sealant products and their approved uses and a comprehensive PubMed based review of the recent literature (February 2012, through March 2013) on the laboratory and clinical use of fibrin sealant are provided. Product information is organized into sections based on a classification system for commercially available materials. Publications are presented in sections based on both laboratory research and clinical topics are listed in order of decreasing frequency. Results. Fibrin sealant remains useful hemostat, sealant, and adhesive. New formulations and applications continue to be developed. Conclusions. This agent remains clinically important with the recent introduction of new commercially available products. Fibrin sealant has multiple new uses that should result in further improvements in patient care.

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Section: Most Frequent Fibrin Sealant Clinical Literature Applicatmentioning

confidence: 99%

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

2014

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“…Fibrin glue is a bloodderived product that is used as a surgical tissue adhesive. The combination of PGA sheet and fibrin glue has been widely used in the surgical field [13][14][15], and it is subsequently being used as a prevention and treatment method for post-ESD adverse events [16][17][18][19][20]. Based on this background information, we assessed the efficacy and safety of the covering method using PGA sheets and fibrin glue in preventing post-ESD bleeding in patients receiving ongoing antithrombotic agents.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of polyglycolic acid sheets and fibrin glue for prevention of bleeding after gastric endoscopic submucosal dissection in patients under continued antithrombotic agents

et al. 2018

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“…PGA sheets are hydrolyzed in vivo , with subsequent degradation and absorption, and their coating effect is known to be enhanced if they are applied in combination with FG [24]. This combined PGA-FG therapy has been widely used in multiple surgical fields, and several studies have reported on its safety and efficacy [7, 9, 25,26,27]. In addition, PGA-FG composites have been utilized as sealants during orthopedic surgery and as a means of achieving hemostasis during liver and pancreatic surgery [31].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the wound healing efficacy of polyglycolic acid sheets with fibrin glue and gelatin sponge dressings in a rat cranial periosteal defect model

et al. 2016

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Oral surgical procedures occasionally require removal of the periosteum due to lesions, and these raw bone surfaces are prone not only to infection but also to scar formation during secondary healing. The objective of this study was to identify successful methods for reconstruction using periosteal defect dressings. We created 1-cm2 defects in the skin and cranial periosteum of 10-week-old male Wistar rats under isoflurane anesthesia. The animals were assigned to three defect treatment groups: (1) polyglycolic acid sheets with fibrin glue dressing (PGA-FG), (2) Spongel® gelatin sponge dressing (GS), and (3) open wound (control). Postoperative wound healing was histologically evaluated at 2, 4, and 6 weeks. The moist conditions maintained by the GS and PGA-FG treatments protected the bone surface from the destructive effects of drying and infection. Complete wound healing was observed in the GS group but not for all animals in the PGA-FG and control groups. Histologically, osteoblast proliferation on bone surfaces and complete epithelialization with adnexa were observed in the GS group at 6 weeks after surgery. In contrast, PGA sheets that had not been absorbed inhibited osteoblast proliferation and delayed wound healing in the PGA-FG group. Wound surface dressings maintain a moist environment that promotes wound healing, but PGA materials may not be suitable for cases involving exposed periosteum or bone surfaces due to the observed scar formation and foreign-body reaction.

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Prevention of Alveolar Air Leakage after Video-Assisted Thoracic Surgery: Comparison of the Efficacy of Methods Involving the Use of Fibrin Glue

Abstract: Method III was the most effective for preventing alveolar air leakage.

Cited by 37 publications

References 13 publications

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

Efficacy of polyglycolic acid sheets and fibrin glue for prevention of bleeding after gastric endoscopic submucosal dissection in patients under continued antithrombotic agents

Comparison of the wound healing efficacy of polyglycolic acid sheets with fibrin glue and gelatin sponge dressings in a rat cranial periosteal defect model

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