Prevention of Atopic Dermatitis

Williams, Hywel C; Chalmers, Joanne R

doi:10.2340/00015555-3516

Cited by 26 publications

(25 citation statements)

References 65 publications

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“…The authors also studied the hypothesis that probiotics could reduce the incidence of AD by about 20%. Improving the skin barrier from birth to prevent AD and food allergy were also one of the prevention options addressed throughout the study [12].…”

Section: Resultsmentioning

confidence: 99%

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Skin microbiome vs. atopic dermatitis: A review

Maia¹,

Fonseca²

2022

Int. J. Sci. Res. Arch.

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Introduction: The human skin is home-grown to an abundant colonization of bacteria, fungi and viruses. Atopic dermatitis is a chronic or recurrent and pruritic inflammatory skin disease that affects mainly the flexed areas of the skin, affecting the quality of life of the patient. People. In a situation of normal skin without pathology, the bacteria present in greater quantity are Actinobacteria and Firmicutes, and the fungi most easily found are Malassezia and Candida. Aim: This review aims to observe the relationship between the skin microbiome and atopic dermatitis as well as to verify the changes that occur at the microbiome level when faced with this pathology and treatment options. Materials and Methods: To carry out this literature review, articles were collected from “Pubmed”, “NCBI” and “Google schoolar” databases, publications dates between 2005 and 2020. Results and discussion: There are several treatment options for this disease, the use of topical corticosteroids, emollients and topical moisturizing therapy remains the therapy of choice. When an exacerbation of bacterial proliferation is observed, the use of antibiotics, namely anti-staphylococcal drugs, is advisable since there is a considerable increase in the proliferation of Staphylococcus aureus (S. aureus) throughout the course of the disease. Conclusion: According to the bibliography used, it is concluded that during the disease there is an increase in the S. aureus community as well as the loss of bacterial diversity in the skin, and the increase in S. aureus colonization is facilitated by changes that occur in it due to the presence of the pathology.

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Section: Resultsmentioning

confidence: 99%

“…Primary prevention refers to intervention before health effects occur. Secondary prevention involves detecting the disease at an early stage in order to prevent its worsening and tertiary prevention is the reduction of symptoms or improvement in the quality of life of those with an already established disease [12].…”

Section:  Biological Therapymentioning

confidence: 99%

Skin microbiome vs. atopic dermatitis: A review

Maia¹,

Fonseca²

2022

Int. J. Sci. Res. Arch.

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“…Vitamin D is thought to have effects on skin barrier function as well as immune system function. 73,74 Atopic dermatitis seems to be correlated with low vitamin D; 73,[75][76][77] however, the causation of this relationship is disputed between 2 leading theories: (1) low sun exposure leads to decreased vitamin D production which impacts AD-related cytokine activity, 78 (2) the chronic inflammation caused by AD produces a low vitamin D state. 79 A systematic review of vitamin D supplementation for primary prevention 74 of atopic dermatitis found little evidence that antepartum or infant supplementation prevented development of atopic dermatitis.…”

Section: Vitamin D and Chronic Painmentioning

confidence: 99%

An Evidence-Based Review of Vitamin D for Common and High-Mortality Conditions

et al. 2022

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Background: Vitamin D is a fat-soluble vitamin available from food and sun exposure. Vitamin D receptors are present in cells throughout the body and cause it to act like a hormone. Observational studies document the association of low vitamin D levels with multiple health conditions. This article reviews the evidence for vitamin D in prevention and treatment in primary care.Methods: We performed a literature review of randomized controlled trials, meta-analyses, systematic reviews, and large prospective trials looking at the role of vitamin D deficiency in the most common conditions seen in primary care and the top 10 causes of mortality since 2010.Results: Vitamin D supplementation in patients with known cardiovascular disease does not reduce risk of stroke or heart attack. Vitamin D supplementation does not seem to have an effect in the treatment of hypertension or in cancer prevention. There is emerging evidence that supplementation reduces COVID-19 severity and risk of mechanical ventilation. Vitamin D at more moderate levels may reduce the risk of falls, but higher doses may cause increased fall risk. There does not seem to be a link between vitamin D supplementation and improved cognition. Vitamin D supplementation may be helpful in patients with major depression. High dose vitamin D may improve pain in people with fibromyalgia. Supplementing patients with prediabetes reduced the risk of progression to type 2 diabetes mellitus. Vitamin D supplementation in addition to standard emollient treatment helped to reduce symptoms in people with atopic dermatitis.Conclusion: Prospective studies of vitamin D supplementation demonstrate variable impact on disease specific and patient-oriented outcomes, suggesting a correlation but not a causal relationship between low vitamin D levels and disease pathogenicity. Future research should determine dosing standards and timing of vitamin D in treatment and prevention.

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“…Большинство периваскулярных Т-лимфоцитов выявляется в активированном состоянии, о чем свидетельствует высокая экспрессия HLA-DR и рецепторов к IL-2, что, в свою очередь, косвенно свидетельствует о постоянной готовности иммунных клеток кожи к специфическому ответу на антиген. Т-лимфоциты несут на своей поверхности кожный лимфоцитарный антиген (CLA), наличие которого обеспечивает быстрое перемещение этих клеток в кожу после экспозиции с чужеродным антигеном [17].…”

Section: основная частьunclassified

The main aspects of the immunopathogenesis of atopic dermatitis in children

Pobezhimova

Жестков

2021

Allergol. immunol. pediatr.

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Research objective Atopic dermatitis (AtD) is the earliest and most frequent manifestation of the body’s hypersensitivity reaction to environmental allergens. Often manifested in severe form, affecting the skin, can occur in early infancy, childhood. The disease is genetically determined and is chronic. AtD is one of the most common skin diseases (from 20 to 40% in the structure of skin diseases), which occurs in all countries in people of both sexes. In recent years, there has been an increase in the incidence of AtD throughout the world. The disease is more common in highly developed countries and cities (less commonly in rural areas). AtD significantly reduces the quality of life of children, causing psychological discomfort and disrupting their social adaptation. AtD in children is a risk factor for the «atopic march» — the further sequential development of other allergic diseases: allergic rhinitis, pollinosis, allergic conjunctivitis, bronchial asthma. With a reduced immune response of the body, AtD in children can be complicated by the addition of a secondary infection (bacterial, viral, fungal). Such a high incidence rate, a debut in early childhood, a frequently recurring course of the pathological process, and a tendency towards an increase in the forms of the disease resistant to traditional therapy make the details of the pathogenesis of AtD particularly relevant. One of the main roles in the pathogenesis of AtD belongs to the cells of the immune system. The purpose of this article: to systematize the information available today on the immunopathogenesis of atopic dermatitis.

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Prevention of Atopic Dermatitis

Cited by 26 publications

References 65 publications

Skin microbiome vs. atopic dermatitis: A review

Skin microbiome vs. atopic dermatitis: A review

An Evidence-Based Review of Vitamin D for Common and High-Mortality Conditions

The main aspects of the immunopathogenesis of atopic dermatitis in children

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