Prevention of cancer risk of workers of glass fibers manufacture

Abstract

In the long glass fibers manufacture, operators are exposed to a complex of carcinogenic chemicals discharged into the working environment (including formaldehyde, chloromethyl oxirane, hydrochloride, ethanoic Malignant neoplasm is one of the greatest medical concerns. The given pathology is the second leading cause of death, following just behind cardiovascular diseases. Official statistics show a steady increase in cancer incidence and mortality in Russia. The growth in the cancer morbidity rate over the last 10 years has exceeded 17% [5].

Fluorometric Paper-Based, Loop-Mediated Isothermal Amplification Devices for Quantitative Point-of-Care Detection of Methicillin-Resistant Staphylococcus aureus (MRSA)

“…This finding suggested no effect of the dried reagents and PVA and supported the user-friendly platform of the device since all of the LAMP ingredients were dried on the reaction pad and the users would only add 14 μL of sterile water and 1 μL of DNA sample upon use (Figure C, DNA sample from 5 min boiling). Using a cellulose membrane paper with simple fabrication offers our paper-based device to be able to be constructed at local settings, the low production cost, and safe health and environment compared to those that were constructed from glass fiber and plastic materials. ,, Next, we evaluated the shelf life of the paper-based LAMP device following different days of room temperature (25 °C) storage. Testing on crude DNA from individual bacterial species culture, the percent efficiency of the LAMP reaction (determined from five repetitive experiments) remained at 85 ± 2.98% for 35 days (Figure C).…”

“…Using a cellulose membrane paper with simple fabrication offers our paper-based device to be able to be constructed at local settings, the low production cost, and safe health and environment compared to those that were constructed from glass fiber and plastic materials. 23,24,52 Next, we evaluated the shelf life of the paper-based LAMP device following different days of room temperature (25 °C) storage. Testing on crude DNA from individual bacterial species culture, the percent efficiency of the LAMP reaction (determined from five repetitive experiments) remained at 85 ± 2.98% for 35 days (Figure 3C).…”

“…Additionally, the prototype construction of both designs are complicated and required some special instruments, such as a photolithograph and a plastic molder (CO 2 laser), , while we aimed to construct a prototype that could be made locally without any special instrument. For disposal recycling, the polymers glass fiber and PET are also known to induce carcinogenesis, so the waste requires special management. , We herein developed a ready-to-use and carcinogenic free (human health safe), cellulose paper-based LAMP device by utilizing the interaction between a biotin-tagged primer and a streptavidin central composite design (CCD) for optimizing LAMP reagents and conditions, coupled with a DNA fluorescent dye (e.g., SYBR Green I) for rapid point-of-care identification of MRSA. The sensitivity and specificity, as well as the stability of the paper-based LAMP activity and assay efficiency, were determined using laboratory strains and clinical blood samples.…”

Safety and Health Concerns for the Users of a Playground, Built with Reused Rotor Blades from a Dismantled Wind Turbine

“…[13,14] (p. 65)"). Since particles of the glass fibres could also reach the lungs through breathing, they are suspected of causing respiratory irritation and even cancer [11,12,[15][16][17]. In Wikado the health risks concerning these severe diseases are highly unlikely since the amount of glass fibres exposed is minimal.…”

Absence of GSTT1 and polymorphisms in GSTP1 and TP53 are associated with the incidence of acne vulgaris

“…13 The GST and TP53 genotype has been linked to a number of diseases in numerous investigations. [14][15][16] However, there is limited data available from Pakistan that reports the association between various single nucleotide polymorphisms (SNPs) and the incidence of acne vulgaris. Hence, the present investigation was aimed to report the effect of presence or absence of GSTM1 and/or GSTM1 and genotypes at SNPs in GSTP1 (rs1695) and TP53 (rs1042522) genes on the incidence of acne vulgaris.…”