Prevention of cisplatin-induced kidney epithelial cell apoptosis with a Cu superoxide dismutase-mimetic

Wangila, Grant W.; Nagothu, Kiran K.; Steward, Richard; Bhatt, Renu; Iyere, Peter Abeta; Willingham, William M.; Sorenson, John R. J.; Shah, Sudhir V.; Portilla, Didier

doi:10.1016/j.tiv.2006.04.002

Cited by 21 publications

(22 citation statements)

References 36 publications

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“…The IC 50 for complex 1 is comparable with that reported for the trans-bis (benzimidazole) 2 bis (salicylato) copper (II) complex (Table 2) [15]. The IC 50 values for complexes 2-4 were of the same order or better than those obtained for copper complexes showing pharmacological properties associated with the dismutation of O ÅÀ 2 radical, such as those for copper complexes of non-steroidal antiinflammatory drugs, showing enhanced anti-inflammatory effects [2,5,12,15,16].…”

Section: Superoxide Dismutase Activitysupporting

confidence: 80%

“…Salicylic acid (a) and its derivatives have been used for many years as anti-inflammatory, antipyretic and analgesic drugs. Binary and ternary Cu (II) complexes of salicylic acid and its derivatives with basic ligands have been found to exhibit several pharmacological effects suggesting treatment of many pathological disease states [3][4][5][6][7][8][9][10]. These disease states include many inflammations, seizures, gastric and intestinal ulcers, diabetes, neoplasias carcinogenesis, convulsion, mutagenesis, ischemia-reperfusion injury, and radiation injury.…”

Section: Introductionmentioning

confidence: 99%

“…The use of SOD enzyme as pharmaceutical agent is limited because of its instability and low membrane permeability, resulting from its high molecular weight (about 32 KDa). So, low molecular weight mononuclear and binuclear Cu (II) complexes have designed and synthesized as mimics for Cu, Zn-SOD [5][6][7], including binary and ternary copper complexes of anti-inflammatory drugs [2,[5][6][7]. Because the native SOD enzyme has four imidazole nitrogen atoms coordinated to Cu (II) [11], it was proposed that the presence of coordination sites belonging to nitrogen hetero-aromatic rings such as imidazole, pyridine and pyrazole is important for high SOD activity [15,29,30].…”

Section: Introductionmentioning

confidence: 99%

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Mononuclear copper (II) salicylate complexes with 1,2-dimethylimidazole and 2-methylimidazole: Synthesis, spectroscopic and crystal structure characterization and their superoxide scavenging activities

Abuhijleh

2010

Journal of Molecular Structure

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Section: Superoxide Dismutase Activitysupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mononuclear copper (II) salicylate complexes with 1,2-dimethylimidazole and 2-methylimidazole: Synthesis, spectroscopic and crystal structure characterization and their superoxide scavenging activities

Abuhijleh

2010

Journal of Molecular Structure

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“…The metal complexes Cu(II)(DIPS) 4 (8), Zn(II)(DTBS) 2 (8), and Cu(II) 2 (DTBS) 4 (9) were synthesized by methods reported in the literature. Cu(II) 2 (DBS) 4 and Zn(II)(DTBS) 2 were synthesized in our laboratory by a procedure listed below.…”

Section: Methodsmentioning

confidence: 99%

Thorough Study of Reactivity of Various Compound Classes toward the Folin−Ciocalteu Reagent

Everette

Bryant

Green

et al. 2010

J. Agric. Food Chem.

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684

469

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A thorough study was done to test the reactivity of the Folin-Ciocalteu (F-C) reagent towards various compound classes. Over 80 compounds were tested. Compound classes included phenols, thiols, vitamins, amino acids, proteins, nucleotide bases, unsaturated fatty acids, carbohydrates, organic acids, inorganic ions, metal complexes, aldehydes and ketones. All phenols, proteins and thiols tested were reactive towards the reagent. Many vitamin derivatives were also reactive, as were the inorganic ions Fe+2, Mn+2, I− and SO3−2. Other compounds showing reactivity included the nucleotide base guanine and the trioses glyceraldehyde and dihydroxyacetone. Copper complexation enhanced the reactivity of salicylate derivatives towards the reagent while zinc complexation did not. Several amino acids and sugars which were reported to be reactive towards the F-C reagent in earlier studies were found not to be reactive in our study, at least in the concentrations used. Reaction kinetics of each compound with the F-C reagent were also measured. Most compounds tested showed a biphasic kinetic pattern with half lives under one minute. Trolox and ascorbic acid displayed a rapid monophasic pattern in which the reaction reached endpoint within one minute. In summary, our study has shown that the F-C reagent is significantly reactive towards other compounds besides phenols. As other investigators have suggested, the F-C assay should be seen as a measure of total antioxidant capacity rather than phenolic content. Since phenolics are the most abundant antioxidants in most plants, it gives a rough approximation of total phenolic content in most cases.

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“…The adverse changes in some animals were almost completely abolished with CN treatment (el-Saadani 2004;Salama et al 2007). Copper complex is antiapoptotic, control cellular differentiation and proliferation, superoxide dismutase (SOD)-mimetic free radical scavengers (Sorenson 2002;Wangila et al 2006). Salama et al (2007) found that copper nicotinate reduces total lipids in sera hepatic tissue as well as regulate levels of alanine transaminase, aspartate transaminase, alkaline phosphatase, gamma glutamyl transpeptidase and oxidative markers such as nitric oxide and lipid peroxidation in rat models.…”

Section: Introductionmentioning

confidence: 99%

Physiological studies on the effect of copper nicotinate (Cu–N complex) on the fish, Clarias gariepinus, exposed to mercuric chloride

Al-Salahy

2010

Fish Physiol Biochem

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Female catfish, Clarias gariepinus, were collected from the Nile River at Assiut region, were divided into 7 groups. The first group was left as control, and the second was treated with mercuric chloride (MC) for 3 weeks following by normal water for 1 week. The third, fourth and fifth groups were provided by MC (150 μg/ l of water). This treatment was continued for 3 weeks. Then, the fish were received CN instead of MC, for 1 week, with 15 and 25 mg CN/100 g wet food. The fifth fish group received diet supplemented with vit E (α-tocopherol) (100 mg/kg wet diet), for 1 week, instead of MC treatment. Vitamin E was used as standard antioxidant drug. Following 3 weeks of normal ambient water, the sixth and seventh aquaria received only CN for 1 week, with 15 and 25 mg CN respectively/100 g wet food, respectively. At the end of the experiment, Samples of liver, kidneys (posterior part), gills (right gills) and ovary were excised. The measurement included the oxidative stress parameters: carbonyl protein and total peroxide and the antioxidant enzyme activities superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST) in all selected organs. MC treatment induced harmful effect in fish, probably due to its enhancing effect on reactive oxygen species (ROS) production in fish organs especially the respiratory and osmoregulatory organs namely gills. The result suggests that this gill damage may exert hypoxic case, anoxia for different organs and some Cu excretion resulting in a magnification of ROS overproduction. Also, the observed oxidative stress in ovary tissue of MC-treated fish may affect fish fertility. The addition of CN in fish diets could protect the fish C. gariepinus against MC-induced oxidative damage showing recovery of fish organs. It could suggest that the detoxifying mechanism of action of CN is mainly due to its scavenging activity of free radicals rather than tissue healing.

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Prevention of cisplatin-induced kidney epithelial cell apoptosis with a Cu superoxide dismutase-mimetic

Cited by 21 publications

References 36 publications

Mononuclear copper (II) salicylate complexes with 1,2-dimethylimidazole and 2-methylimidazole: Synthesis, spectroscopic and crystal structure characterization and their superoxide scavenging activities

Mononuclear copper (II) salicylate complexes with 1,2-dimethylimidazole and 2-methylimidazole: Synthesis, spectroscopic and crystal structure characterization and their superoxide scavenging activities

Thorough Study of Reactivity of Various Compound Classes toward the Folin−Ciocalteu Reagent

Physiological studies on the effect of copper nicotinate (Cu–N complex) on the fish, Clarias gariepinus, exposed to mercuric chloride

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