Prevention of Colorectal Cancer by Colonoscopic Polypectomy

Sj, Winawer; Zauber, Ann G.; Ho, May Nah; O’Brien, Michael; Gottlieb, Leonard S.; Sternberg, Stephen S.; Waye, Jerome D.; Schapiro, Melvin; Bond, John H.; Panish, Joel F.

doi:10.1056/nejm199312303292701

Cited by 4,147 publications

(2,440 citation statements)

References 20 publications

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“…The rate of new cases has been declining steadily over the past two decades1 possibly due to increased screening and early detection and removal of precancerous lesions, adenomas or polyps 2, 3, 4, 5. Early mutations in colon adenomas can initiate tumor development 6.…”

Section: Introductionmentioning

confidence: 99%

Mutation analysis of adenomas and carcinomas of the colon: Early and late drivers

Wolff

Hoffman

Wolff

et al. 2018

Genes Chromosomes & Cancer

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Colorectal cancer (CRC) accounts for about 8% of all new cancer cases diagnosed in the US. We used whole exome sequence data from triplet samples (colon carcinoma, colon adenoma, and normal tissue) from 18 individuals to assess gene mutation rates. Of the 2 204 genes that were mutated, APC, TTN, TP53, KRAS, OBSCN, SOX9, PCDH17, SIGLEC10, MYH6, and BRD9 were consistent with genes being an early driver of carcinogenesis, in that they were mutated in multiple adenomas and multiple carcinomas. Fifty‐two genes were mutated in ≥12.5% of microsatellite stable (MSS) carcinomas but not in any of the adenomas, in line with the profile of a late driver event involved in tumor progression. Thirty‐eight genes were sequenced in a larger independent set of 148 carcinoma/normal tissue pairs to obtain more precise mutation frequencies. Eight of the genes, APC, TP53, ATM, CSMD3, LRP1B, RYR2, BIRC6, and MUC17, contained mutations in >20% of the carcinomas. Interestingly, mutations in four genes in addition to APC that are associated with dysregulation of Wnt signaling, were all classified as early driver events. Most of the genes that are commonly associated with colon cancer, including APC, TP53, and KRAS, were all classified as being early driver genes being mutated in both adenomas and carcinomas. Classifying genes as potential early and late driver events points to candidate genes that may help dissect pathways involved in both tumor initiation and progression.

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Section: Introductionmentioning

confidence: 99%

Mutation analysis of adenomas and carcinomas of the colon: Early and late drivers

Wolff

Hoffman

Wolff

et al. 2018

Genes Chromosomes & Cancer

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“…For instance, colonoscopic removal of focal lesions (adenomatous polyps) has been shown to dramatically reduce the incidence of future colorectal cancers (CRCs). 1 On the other hand, identification of field effect in the rectosigmoid may predict risk of neoplasia throughout the colon 2 . Commonly used means of sensing field carcinogenesis include flexible sigmoidoscopy, in which a distal adenoma portends a ~2.5 fold increased risk of neoplasia in the proximal colon 3 .…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic Microvascular Blood Detection From the Endoscopically Normal Colonic Mucosa: Biomarker for Neoplasia Risk

et al. 2008

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Background & Aims-We have previously utilized a novel biomedical optics technology, fourdimensional elastically-scattered light fingerprinting, to demonstrate that in experimental colon carcinogenesis, the predysplastic epithelial microvascular blood content is markedly elevated. In order to assess the potential clinical translatability of this putative field effect marker, we characterized the early increase in blood supply (EIBS) in humans in vivo.

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“…Generell führt die Abtragung kleiner, singulärer Adenome im Vergleich zur Normalbevölkerung zu einem um bis zu 90 % verminderten Risiko, ein metachrones KRK zu entwickeln [99,100,207,208]. Dieses reflektiert den Vorsorgewert der Koloskopie im Rahmen der Adenom-Karzinom-Sequenz.…”

Section: Hintergrundunclassified

S3-Leitlinie Kolorektales Karzinom Version 1.0 - Juni 2013 AWMF-Registernummer: 021/007OL

et al. 2013

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Prevention of Colorectal Cancer by Colonoscopic Polypectomy

Abstract: Colonoscopic polypectomy resulted in a lower-than-expected incidence of colorectal cancer. These results support the view that colorectal adenomas progress to adenocarcinomas, as well as the current practice of searching for and removing adenomatous polyps to prevent colorectal cancer.

Cited by 4,147 publications

References 20 publications

Mutation analysis of adenomas and carcinomas of the colon: Early and late drivers

Mutation analysis of adenomas and carcinomas of the colon: Early and late drivers

Spectroscopic Microvascular Blood Detection From the Endoscopically Normal Colonic Mucosa: Biomarker for Neoplasia Risk

S3-Leitlinie Kolorektales Karzinom Version 1.0 - Juni 2013 AWMF-Registernummer: 021/007OL

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