Prevention of Experimentally Induced Irritant Contact Dermatitis by Isatis Tinctoria and Tryptanthrin and Its Impact on Uvb-Induced Erythema

Heinemann, Christian; Schliemann‐Willers, S.; Elsner, Peter; Oberthür, Christine; Hamburger, Matthias

doi:10.1097/01206501-200306000-00025

Cited by 27 publications

(43 citation statements)

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“…191 A prenylated derivative 165 of resveratrol, purified from fungally infected peanuts, reduced the LPS-induced COX-2 protein expression better than resveratrol in J774 cells. Resveratrol and 165 suppressed the COX-2 mRNA level by 35 resveratrol isolated from Caragana chamlagu, showed a more potent inhibitory activity on COX-2 than COX-1 enzyme. a-Viniferin inhibited the synthesis of the COX-2 and the iNOS transcript in LPS-activated RAW 264.7 cells.…”

Section: F Stilbenesmentioning

confidence: 96%

“…The treatment with extracts showed significant effects than tryptanthrin in sodium lauryl sulfate (SLS)-induced irritant contact dermatitis in the eliciting phase as compared to the untreated volunteers. 35 Fruits of Evodia rutaecarpa have long been used for inflammatory disorders and contain the active constituents such as rutaecarpine (2), dehydroevodiamine (3), and evodiamine (4) (Fig. 2).…”

Section: Alkaloidsmentioning

confidence: 99%

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Recent developments in anti‐inflammatory natural products

Gautam

Jachak

2009

Medicinal Research Reviews

399

230

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Many of the inflammatory diseases are becoming common in aging society throughout the world. The clinically used anti-inflammatory drugs suffer from the disadvantage of side effects and high cost of treatment (in case of biologics). Alternative to these drugs are traditional medicines and natural products, which offer a great hope in the identification of bioactive lead compounds and their development into drugs for treating inflammatory diseases. Since ancient times traditional medicines and phytopharmaceuticals are being used for the treatment of inflammatory and other disorders. The present review article describes anti-inflammatory natural products derived from plants and marine sources reported during last decade. The compounds described belong to different chemical classes such as alkaloids, steroids, terpenoids, polyphenolics, phenylpropanoids, fatty acids and lipids, and various miscellaneous compounds. The attempt is also being made to enumerate the possible leads, e.g. curcumin, resveratrol, baicalein, boswellic acid, betulinic acid, ursolic acid, and oleanolic acid, for further development with the help of structure-activity relationship (SAR) studies and their current status. In addition SAR studies carried out on the anti-inflammatory activity of flavonoid compounds and clinical studies performed on anti-inflammatory natural products are also discussed.

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Section: F Stilbenesmentioning

confidence: 96%

Section: Alkaloidsmentioning

confidence: 99%

Recent developments in anti‐inflammatory natural products

Gautam

Jachak

2009

Medicinal Research Reviews

399

230

View full text Add to dashboard Cite

show abstract

“…However, clinical trials on the antiinflammatory activity of tryptanthrin conducted in human volunteers using two different models of inflammation did not come up with promising results. While one of which displayed some inhibitory effect, though not statistically significant, the other did not display any activity at all [113].…”

Section: Anti-inflammatory Activitymentioning

confidence: 77%

Quercetin and Tryptanthrin

2015

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“…It was found that they possessed pronounced bronchodilating activity [115,[184][185][186][187]. The alkaloid tryptanthrin (195) showed antibacterial, anti-inflammatory, and antimalarial activity [188][189][190][191][192] (Fig. 6).…”

Section: Electrophilic Substitution In the Aromatic Ring Of Tricyclicmentioning

confidence: 99%