Prevention of Hypertension and Arterial Stiffness by Combination of Centella asiatica and Curcuma longa in Rats

Hasimun, Patonah; Mulyani, Yani; Suprijono, Agus; Sara, Dewa Ayu Embas

doi:10.3923/ajbs.2019.173.179

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…The present study demonstrates that the combination of Centella asiatica and Curcuma longa has a synergistic antihypertensive impact and may help prevent cardiovascular disease through vascular repair. The results on this study corroborate previous reports of antihypertensive and anti-arterial stiffness in the combination of Centella asiatica and Curcuma longa in fresh juice preparations (Hasimun, et al, 2019). The pharmacological effects of ethanol extract from Centella asiatica and Curcuma longa are greater than those of water extracts.…”

Section: Evaluation Of Pulse Wave Velocity (Pwv)supporting

confidence: 91%

“…The study refers to previous studies that reported antihypertensive effects of a combination of Curcuma longa and Centella asiatica in juice preparations with a ratio of 1:1 (Hasimun, et al, 2019). The study of antihypertensive activity was conducted in-vivo for 28 days in male Wistar rats induced by a high-fat diet and 15% fructose drinking water.…”

Section: Animals Protocolmentioning

confidence: 99%

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Influences of Centella Asiatica and Curcuma Longa on Arterial Stiffness in a Hypertensive Animal Model

2021

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There is a strong relationship between arterial stiffness and high blood pressure. Arterial stiffness increases the risk of a cardiovascular event and sudden death, especially in hypertensive patients. This study aimed to determine the effective combination of Centella asiatica and Curcuma longa on arterial stiffness in hypertensive animal models. Twenty-five male rats aged 2-3 months were randomly into five groups. The groups comprising the negative control and positive control group (receiving drug carriers), the test drug group receiving captopril 2.5 mg/kg, the combination of Centella asiatica (CA) and Curcuma longa (CL) doses of 50 and 100 mg/kg. Except for the control group, all groups received a high-fat diet and 25% fructose drinking water for 28 days. On day 15, they received test medicines. On days 0, 14, and 28, systolic and diastolic blood pressures, as well as the PWV (pulse wave velocity), were assessed. Nitric oxide levels in serum were measured using Griess reagents on day 28. The results showed that a combination of CA and CL doses of 50 and 100 mg/kg reduced systolic and diastolic blood pressure accompanied by a decrease in PWV and a statistically significant increase in serum NO levels (p <0.05). It concluded that a combination of CA and CL has the potential as antihypertensive, improving arterial elasticity.

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Section: Evaluation Of Pulse Wave Velocity (Pwv)supporting

confidence: 91%

Section: Animals Protocolmentioning

confidence: 99%

Influences of Centella Asiatica and Curcuma Longa on Arterial Stiffness in a Hypertensive Animal Model

2021

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“…Also, treatment with curcumin can improve aortic stiffness in mice (Nakmareong et al, 2011;Nakmareong et al, 2012). Additionally, Centella asiatica and Curcuma longa reduced blood pressure and enhanced arterial stiffness (Hasimun et al, 2019).…”

Section: Introductionmentioning

confidence: 97%

Antihypertensive activity and acute toxicity of turmeric (Curcuma longa L.) in L-NAME-induced hypertension animals

Hasimun¹,

Mulyani²,

Yulianti³

2022

CRBB

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Hypertension is one of the significant risk factors for cardiovascular disease and can lead to complications. Uncontrolled hypertension can lead to vascular endothelial dysfunction and other complications of cardiovascular disease. This study aimed to determine the effect of turmeric rhizome (Curcuma longa L.) in extracts and the fractions on a hypertensive rat’s model induced by L-NAME 40 mg/kg for three weeks and an acute toxicity study of the extract. Antihypertensive research was performed on male Wistar rats utilizing non-invasive procedures. Turmeric extract at doses of 50, 100, and 200 mg/kg and its fraction of n-hexane, acetyl acetate, and ethanol at a dose of 25 mg/kg, respectively, were given daily per oral for three weeks to 2.5 mg/kg captopril. The systolic and diastolic blood pressure were measured at 0, 21, and 42 days after treatment and was calculated as mean arterial blood pressure (MAP). Acute toxicity testing refers to the OECD 420 Fixed-Dose method with several dosage levels, consists of 300, 2000, and 5000 mg/kg. The turmeric extract at doses of 50, 100, and 200 mg/kg and its fraction of n-hexane, acetyl acetate, and ethanol significantly reduced mean arterial blood pressure (p<0.05) compared to the control group. Acute administration of turmeric extracts up to a dose of 5000 mg/kg in test animals did not show any death. Turmeric and its components are considered to possess antihypertensive actions. Antihypertensive activity increased in a dose-dependent manner. Turmeric extract is categorized as being almost entirely non-toxic.

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“…One of the medicinal plants used by Indonesians is the turmeric plant, which has the Latin name Curcuma longa Linn and is widely known by the public to possess diverse medicinal uses (Winarsih et al, 2012). The plant has pharmacological activity, one of which is used in antihypertensive treatment (Hasimun et al, 2019). Meanwhile, hypertension is a major risk factor for cardiovascular disease (Mozaffarian et al, 2015) which is one of the most common causes of death in the world (WHO, 2018).…”

Section: Introductionmentioning

confidence: 99%

Subcrhonic Toxicity of Curcuma longa (Tumeric) Rhizoma Extract on Rats

Mulyani¹,

Hasimun²,

Nurjanah³

2022

Trad.Med.J

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Toxicity is a condition that indicates a harmful effect contained in a substance such as turmeric, which is an effective traditional medicinal plant used for antihypertensive treatment. Therefore, this study aims to determine the effect of repeated dosing of turmeric (Curcuma longa L.) rhizome extract. This subchronic toxicity study was divided into 4 groups, namely 1 normal treated with 0.5% Na-CMC, and 3 treatments with turmeric extract at doses of 50, 100, and 200 mg/kg BW for 28 days with each group consisting of 5 males and 5 female Wistar rats. The results showed that the turmeric extract at doses of 50, 100, and 200 mg/kg BW did not cause toxicity to liver and kidney biochemistry nor contain any toxic substances that might cause anemia or other abnormalities. Furthermore, histopathological examination showed that the tissues were normal. This indicates that the turmeric rhizome extract at all dose variations indicate non-toxic when used in traditional medicine.

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Prevention of Hypertension and Arterial Stiffness by Combination of Centella asiatica and Curcuma longa in Rats

Cited by 6 publications

References 9 publications

Influences of Centella Asiatica and Curcuma Longa on Arterial Stiffness in a Hypertensive Animal Model

Influences of Centella Asiatica and Curcuma Longa on Arterial Stiffness in a Hypertensive Animal Model

Antihypertensive activity and acute toxicity of turmeric (Curcuma longa L.) in L-NAME-induced hypertension animals

Subcrhonic Toxicity of Curcuma longa (Tumeric) Rhizoma Extract on Rats

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