Prevention of implantation metastases after resection of proximal bile duct tumours with pre-operative low dose radiation therapy

Low-Dose Neoadjuvant External Beam Radiation Therapy for Soft Tissue Sarcoma

“…By using a neoadjuvant EBRT regimen of 3.5 Gy for three fractions, the risk of seeding was reduced to 0% (14). Similar results were noted in an experience with bile duct cancers (15).…”

“…Specifically, 25 patients (59%) were treated with EBRT (median, 40 Gy; range, 20-56.2), 13 patients (31%) were treated with brachytherapy (median, 42 Gy; range, 26-50), and 4 patients (10%) were treated with intraoperative radiation therapy (IORT) (median, 12.5 Gy; range, [8][9][10][11][12][13][14][15][16][17][18][19][20]. The median total dose delivered was 63.3 Gy (range, 28-78.4).…”

Basic techniques in endoscopic ultrasound-guided fine needle aspiration for solid lesions: Adverse events and avoiding them

“…Limited data suggest that tumor seeding correlates with important clinical outcomes including tumor stage, prognosis, resectability, resection margin status, recurrence and survival. [5253545556575859606162] Others report a lack of correlation between tumor seeding and clinical outcomes. [63646566]…”

Role of Preoperative Biliary Drainage in Resectable Hilar Cholangiocarcinoma

“…In absence of dilated bile duct, this technique may be long and laborious. The risk of vascular lesion and post-procedural haemorrhage does exist as reported by Kawakami [12], and tumor seeding of the drain tract has been histologically shown in the specimen with a rate of 5-20% [13,14]. Gerhards and co-authors suggested that preoperative radiotherapy of patients with resectable main bile duct tumor may reduce the risk of tumor seeding [14].…”

“…The risk of vascular lesion and post-procedural haemorrhage does exist as reported by Kawakami [12], and tumor seeding of the drain tract has been histologically shown in the specimen with a rate of 5-20% [13,14]. Gerhards and co-authors suggested that preoperative radiotherapy of patients with resectable main bile duct tumor may reduce the risk of tumor seeding [14]. However, more recent studies reported a lower risk of seeding following PTBD compared to previous literature [15,16].…”