Prevention of Initial Biofilm Formation on Ureteral Stents Using a Sustained Releasing Varnish Containing Chlorhexidine: <i>In Vitro</i> Study

Zelichenko, Genady; Steinberg, Doron; Lorber, Gideon; Friedman, Michael; Zaks, Batia; Lavy, Eran; Hidas, Guy; Landau, Ezekiel H.; Gofrit, Ofer N; Pode, Dov; Duvdevani, Mordechai

doi:10.1089/end.2012.0193

Cited by 29 publications

(15 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The bacterial biofilm can survive in antibiotics with concentrations of 1,000-1,500 times higher than that in which the same type of floating bacteria can be killed. This is an important way for bacteria to fight against adverse environments, cause continuous infections, and generate drug resistance [2,11]. Once the bacterial biofilm is formed, antibacterial agents are, in general, difficult to penetrate into the bacterial biofilm.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Observations of Bacterial Biofilm on Ureteral Stent and Studies on the Distribution of Pathogenic Bacteria and Drug Resistance

et al. 2018

View full text Add to dashboard Cite

Objective: This study aims to observe the morphological characteristics of bacterial biofilm on the surface of ureteral stents and analyze distribution characteristics of pathogens on the bacterial biofilm and drug resistance. Methods: Ureteral stents were sampled from 129 patients. A scanning electron microscope was used to observe the morphological characteristics of bacterial biofilms, and the Congo red medium was applied to screen bacterial biofilm strains on the renal pelvis section, ureter section, and bladder section respectively. Urine culture was performed, and the drug sensitive test analysis was carried out for the pathogenic bacteria detected. Results: Bacterial biofilms can be observed on the surface of ureteral stents, and these bacteria are embraced by large amounts of fiber membranes. A total of 107 patients were found to be positive for biofilms with a positive rate of 82.9%. The positive rates of the bladder section, ureter section, renal pelvis section, and urine culture were 85.0, 42.9, 67.3, and 24.3% respectively. Pathogenic bacteria mainly concentrated on Escherichia coli, and the drug resistance rate of the bacterial biofilm strains on the ureteral stent was relatively higher. Conclusion: The bacterial biofilm on the ureteral stent is an important factor that induces catheter-associated urinary tract infections.

show abstract

Section: Discussionmentioning

confidence: 99%

“…It was found that the formation of bacterial biofilms on the surface of ure-teral stents play an important role in this process [2]. Hence, in this study, an analysis was conducted on the morphology of bacterial biofilm on the ureteral stent retained in patients and its etiology, in order to provide references for clinical treatment.…”

Section: Introductionmentioning

confidence: 99%

Observations of Bacterial Biofilm on Ureteral Stent and Studies on the Distribution of Pathogenic Bacteria and Drug Resistance

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Ethylcellulose varnish formulations containing chlorhexidine were also applied to ureteral stents to minimize urinary tract bacterial colonization and proliferation on the stent surface. They effectively prolonged growth inhibition of Enterococci , Pseudomonas , and Escherichia coli for between 1 and 2 weeks (Zelichenko et al, 2013).…”

Section: Macro-structured Delivery Systems Fabricated From Ethylcellumentioning

confidence: 99%

Premium ethylcellulose polymer based architectures at work in drug delivery

Adeleke

2019

International Journal of Pharmaceutics: X

View full text Add to dashboard Cite

show abstract

“…Stents become blocked due to encrustation caused by the formation of these structures [18]. To reduce the adhesion of microbial cells and the rate of bacterial biofilm development, urological catheters are coated with different substances, such as nano-silver [7,19,20], metallic nanoparticles [20,21], Lysostaphin [22], Chlorhexidine [23], antifouling zwitterionic moieties (containing an equal number of positively and negatively charged functional groups) [24], polyvinylpyrrolidone (PVP, a water-soluble polymer) [8], nitrofurazone [19], polytetrafluoroethylene (PTFE), hydrogel [5], and impregnation with a combination of rifampicin, sparfloxacin, and triclosan [25]. Bacterial biofilm formation and encrustation may cause obstruction or blockage of ureteral stents [8].…”

Section: Introductionmentioning

confidence: 99%

Surface analysis of ureteral stent before and after implantation in the bodies of child patients

2020

View full text Add to dashboard Cite

The aim of this work was to determine which part of a double-J ureteral stent (DJ stents) showed the highest tendency to crystal, calculi, and biofilm deposition after ureterorenoscopic-lithotripsy procedure (URS-L) to treat calcium oxalate stones. Additionally, the mechanical strength and the stiffness of DJ stents were evaluated before and after exposure to urine. Obtained results indicated that the proximal (renal pelvis) and distal (urinary bladder) part is the most susceptible for post-URS-L fragments and urea salt deposition. Both, the outer and inner surfaces of the DJ ureteral stents were completely covered even after 7 days of implantation. Encrustation of DJ stents during a 31-day period results in reducing the Young’s modulus by 27–30%, which confirms the loss of DJ stent elasticity and increased probability of cracks or interruption. Performed analysis pointed to the need to use an antibacterial coating in the above-mentioned part of the ureteral stent to prolong its usage time and to prevent urinary tract infection.

show abstract

Prevention of Initial Biofilm Formation on Ureteral Stents Using a Sustained Releasing Varnish Containing Chlorhexidine: In Vitro Study

Abstract: We believe this technique may play a significant role in reducing ureteral stent-associated UTIs. Further studies are needed before this approach can be implemented in clinical practice.

Cited by 29 publications

References 25 publications

Observations of Bacterial Biofilm on Ureteral Stent and Studies on the Distribution of Pathogenic Bacteria and Drug Resistance

Observations of Bacterial Biofilm on Ureteral Stent and Studies on the Distribution of Pathogenic Bacteria and Drug Resistance

Premium ethylcellulose polymer based architectures at work in drug delivery

Surface analysis of ureteral stent before and after implantation in the bodies of child patients

Contact Info

Product

Resources

About