Prevention of Microvascular Complications of Diabetes

Crasto, Winston; Patel, Vinod; Davies, Melanie J.; Khunti, Kamlesh

doi:10.1016/j.ecl.2021.05.005

Cited by 50 publications

(40 citation statements)

References 53 publications

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“…The onset and progression of diabetic microvascular complications (retinopathy, nephropathy, and neuropathy) can be delayed by intensive glycemic control. This finding has been shown in type 1 DM, but the current evidence in type 2 DM is weak[ 30 - 32 ]. However, no specific therapeutic agent or approach other than glycemic control can modify the progression of microvascular complications[ 7 , 10 ].…”

Section: Current Evidence For Preventionsupporting

confidence: 53%

Management of diabetic foot ulcers and the challenging points: An endocrine view

Doğruel¹,

Aydemir²,

Balcı³

2022

WJD

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Diabetic foot ulcers (DFU) are one of the most challenging complications of diabetes. Up to one-third of patients with diabetes mellitus (DM) may suffer from DFUs during their life. DFU is one of the leading causes of morbidity in patients with DM. The treatment period is challenging, and the recurrence rate of DFUs is high. Hence, establishing prevention strategies is the most important point to be emphasized. A multidisciplinary approach is necessary in the prevention and treatment of DFUs. Patients at risk should be identified, and prevention measures should be taken based on the risk category. Once a DFU is formed, the appropriate classification and evidence-based treatment interventions should be executed. Glycemic control, diagnosis and treatment of vascular disease, local wound care, diagnosis, and treatment of infection should be addressed along with the proper evaluation and management of general health status.

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Section: Current Evidence For Preventionsupporting

confidence: 53%

Management of diabetic foot ulcers and the challenging points: An endocrine view

Doğruel¹,

Aydemir²,

Balcı³

2022

WJD

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“…Serious complications affecting the nerves and blood vessels can occur as the course of diabetes progresses. Specifically, cardiovascular disease is one of the most common clinical complications of diabetes [ 1 ]. Elevated blood sugar levels can lead to lipid metabolism problems among vascular endothelial cells and cardiomyocytes and the accumulation of local inflammatory factors.…”

Section: Introductionmentioning

confidence: 99%

Curcumin Attenuates Ferroptosis-Induced Myocardial Injury in Diabetic Cardiomyopathy through the Nrf2 Pathway

Zhang

Shaohuan

Kang

et al. 2022

Cardiovascular Therapeutics

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Diabetes causes lipid peroxide to accumulate within cardiomyocytes. Furthermore, lipid peroxide buildup is a risk factor for ferroptosis. This study is aimed at examining whether curcumin can ameliorate ferroptosis in the treatment of diabetic cardiomyopathy. Hematoxylin and eosin and Masson sections were used to examine the morphology, arrangement, and degree of fibrosis of the myocardium of diabetic rabbit models. The expression levels of nuclear Nrf2, Gpx4, Cox1, and Acsl4 in diabetic animal and cell models were quantitatively analyzed using immunofluorescence and western blotting. Nrf2-overexpression lentivirus vectors were transfected into cardiomyocytes, and the protective effects of curcumin and Nrf2 on cardiomyocytes under high glucose stimulation were assessed using terminal deoxynucleotidyl transferase dUTP nick-end labelling and reactive oxygen species probes. Diabetes was found to disorder myocardial cell arrangement and significantly increase the degree of myocardial fibrosis and collagen expression in myocardial cells. Curcumin treatment can increase nuclear transfer of Nrf2 and the expression of Gpx4 and HO-1, reduce glucose induced myocardial cell damage, and reverse myocardial cell damage caused by the ferroptosis inducer erastin. This study confirmed that curcumin can promote the nuclear translocation of Nrf2, increase the expression of oxidative scavenging factors, such as HO-1, reduce excessive Gpx4 loss, and inhibit glucose-induced ferroptosis in cardiomyocytes. This highlights a potentially new therapeutic route for investigation for the treatment diabetic cardiomyopathy.

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“…The largest cluster for co-cited reference was labeled as “diabetes complications.” The most relevant citer in the cluster was Winston Crasto. He has discussed the microvascular complications of diabetes, including DN, DR, and diabetic neuropathy, and provides best practice clinical care recommendations to guide health care professionals to better manage people with these conditions ( Crasto et al, 2021 ). Additionally, cluster #2 was labeled as “methylenetetrahydrofolate reductase (MTHFR)”.…”

Section: Discussionmentioning

confidence: 99%

Status and Trends of the Association Between Diabetic Nephropathy and Diabetic Retinopathy From 2000 to 2021: Bibliometric and Visual Analysis

et al. 2022

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Background: Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of diabetes that share a similar pathogenesis and clinical relevance. The study aimed to visually analyze the research status and development trend of the relationship between DN and DR by means of bibliometrics and knowledge mapping.Methods: Publications were collected from the Science Citation Index-Expanded of the Web of Science Core Collection between 2000 and 2021. CiteSpace, Alluvial Generator, and Microsoft Excel were used to analyze and present the data.Results: A total of 3,348 publications were retrieved and 3,285 were included in the analysis after deduplication. The publications demonstrated an annually increasing trend. The results of the collaborative network analysis showed that the United States, Steno Diabetes Center, and Tien Y. Wong were the most influential country, institution and author, in this field of research, respectively. The analysis of references and keywords showed that the pathogenesis of DN and DR and their relationship with cardiovascular disease are research hotspots. The clinical relevance and drug therapy for DN and DR will become frontiers of future research in this field.Conclusion: This study is the first to visualize the correlation between DN and DR using a bibliometric approach. This study provides a reference of research trends for scholars.

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Prevention of Microvascular Complications of Diabetes

Cited by 50 publications

References 53 publications

Management of diabetic foot ulcers and the challenging points: An endocrine view

Management of diabetic foot ulcers and the challenging points: An endocrine view

Curcumin Attenuates Ferroptosis-Induced Myocardial Injury in Diabetic Cardiomyopathy through the Nrf2 Pathway

Status and Trends of the Association Between Diabetic Nephropathy and Diabetic Retinopathy From 2000 to 2021: Bibliometric and Visual Analysis

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