Prevention of Ocular Inflammation Induced by Lens Protein, Endotoxin, and Interleukin-1 with Synthetic Interleukin-1 Blockers

Chiou, George C.Y.; Yao, Quansheng; Okawara, Tadashi

doi:10.1089/jop.1994.10.577

Cited by 23 publications

(30 citation statements)

References 8 publications

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“…They were much more potent than prednisolone which required at least 20 mg/kg t.i.d. to reach a lesser extent of anti-inflammation than these 3 compounds [8].…”

Section: Resultsmentioning

confidence: 92%

“…CK 125, CK 126 and CK 128 showed 2-to 7-fold higher potency than prednisolone in inhib- iting IL-1-induced uveitis in this study ( fig. 2-4) [8]. Furthermore, they inhibited the proliferation of fibroblast-like corneal and conjunctival cells ( fig.…”

Section: Discussionmentioning

confidence: 94%

“…Some stable synthetic compounds have been developed in this lab [8][9][10][11][12], and CK 125, CK 126 and CK 128 are the newest compounds tested in the IL-1-induced uveitis of the rat model.…”

Section: Introductionmentioning

confidence: 99%

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Antiuveitis and Inhibition of Fibroblast-Like Corneal and Conjunctival Cell Cultures by Interleukin-1 Blockers, CK 125, CK 126 and CK 128

et al. 1998

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Three new interleukin-1 (IL-1) blockers, CK 125, CK 126 and CK 128, were studied for their effects on IL-1-induced uveitis in rat eyes. They were more potent (at 3–10 mg/kg t.i.d.) than prednisolone (20 mg/kg t.i.d.) in effectively inhibiting posterior uveitis. They were also found to inhibit fibroblast-like corneal cells at 10–300 µg/ml concentrations and conjunctival cells at 1–30 µg/ml levels. The incorporation of leucine into corneal and conjunctival cells was either stimulated or unaffected by CK 126, indicating that the inhibition of cell growth has nothing to do with the protein synthesis. However, the incorporation of uridine into corneal and conjunctival cells was markedly inhibited by CK 126 at 3–30 µg/ml concentrations whereas the incorporation of thymidine into the cells was inhibited at a lesser extent than that of uridine. These results indicate that cell inhibition by CK 126 could be related mainly to the synthesis of mRNA and, to a lesser extent, to DNA synthesis.

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“…They were much more potent than prednisolone which required at least 20 mg/kg t.i.d. to reach a lesser extent of anti-inflammation than these 3 compounds [8].…”

Section: Resultsmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 94%

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Antiuveitis and Inhibition of Fibroblast-Like Corneal and Conjunctival Cell Cultures by Interleukin-1 Blockers, CK 125, CK 126 and CK 128

et al. 1998

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“…The recent discovery of synthetic IL-1 blockers which produce potent anti-inflammatory actions with few sideeffects, if any, is most exciting and warrants further studies [1,[4][5][6]. It has been found in this study that CK130 is the most potent anti-inflammatory agent of approximately 150 compounds investigated [1,[4][5][6][7][8][9][10][11].…”

Section: Resultsmentioning

confidence: 99%

“…Recently, it has been found that interleukin-1 (IL-1) is a major cytokine producing broadspectrum inflammation [1]. Thus, IL-1 blockers could become strong NSAIDs, much more so than arachidonate-related NSAIDs to prevent/treat ocular inflammation [1,[4][5][6][7][8]. In this study, two potent IL-1 blockers, CK130 and CK131, have been identified which block effectively IL-l-induced uveitis in rat eyes.…”

Section: Introductionmentioning

confidence: 99%

Anti-uveitis and inhibition of fibroblast-like corneal and conjunctival cells by interleukin-1 blockers

Xuan

Chiou

1998

Inflammopharmacol

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Effects of interleukin-1 (IL-1) blockers, CK130 and CK131, on IL-1-induced uveitis and proliferation of fibroblast-like corneal and conjunctival cells were investigated in this study. It was found that CK130 and CK131 inhibited IL-1-induced uveitis in rat eyes effectively at 3 mg/kg and 10 mg/kg, respectively. Further, CK130 and CK131 inhibited fibroblast-like corneal and conjunctival cell growth effectively at 10-300 microg/ml and 30-300 microg/ml, respectively. It was also found that DNA synthesis was markedly reduced by CK130 and CK131 at 30-100 microg/ml. RNA synthesis was also inhibited by these CK compounds but protein synthesis was little affected or enhanced.

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Metal‐Free Selective Synthesis of 1,4‐Dihydropyridazines from Hydroxypyrrolines and Hydrazines

et al. 2017

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Prevention of Ocular Inflammation Induced by Lens Protein, Endotoxin, and Interleukin-1 with Synthetic Interleukin-1 Blockers

Cited by 23 publications

References 8 publications

Antiuveitis and Inhibition of Fibroblast-Like Corneal and Conjunctival Cell Cultures by Interleukin-1 Blockers, CK 125, CK 126 and CK 128

Antiuveitis and Inhibition of Fibroblast-Like Corneal and Conjunctival Cell Cultures by Interleukin-1 Blockers, CK 125, CK 126 and CK 128

Anti-uveitis and inhibition of fibroblast-like corneal and conjunctival cells by interleukin-1 blockers

Metal‐Free Selective Synthesis of 1,4‐Dihydropyridazines from Hydroxypyrrolines and Hydrazines

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