Prevention of oral mucositis in patients treated with high-dose chemotherapy and bone marrow transplantation: A randomised controlled trial comparing two protocols of dental care

Borowski, B; Benhamou, E; Jl, Pico; Laplanche, Agnès; Margainaud, J.-P.; Hayat, M.

doi:10.1016/0964-1955(94)90059-0

Cited by 161 publications

(116 citation statements)

References 15 publications

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“…Using the Somerfield criteria [64], they classified guidelines into three types: recommendation, suggestion, or no guideline possible (due to little or no evidence or a lack of consensus on the interpretation of existing evidence). The evidence for each intervention, and 1994 [6] HSCT with TBI T the draft guidelines, were discussed at a Guidelines Update Meeting held in Athens, Greece, in 2011. Based on this input, the preliminary guidelines were revised and subsequently finalized for presentation in this paper.…”

Section: Methodsmentioning

confidence: 99%

Systematic review of basic oral care for the management of oral mucositis in cancer patients

McGuire

Fulton²,

Park

et al. 2013

Support Care Cancer

219

151

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Purpose The purpose of this project was to evaluate research in basic oral care interventions to update evidence-based practice guidelines for preventing and treating oral mucositis (OM) in cancer patients undergoing radio-or chemotherapy. Methods A systematic review of available literature was conducted by the Basic Oral Care Section of the Mucositis Study Group of MASCC/ISOO. Seven interventions-oral care protocols, dental care, normal saline, sodium bicarbonate, mixed medication mouthwash, chlorhexidine, and calcium phosphate-were evaluated using the Hadorn (J Clin Epidemiol 49: [749][750][751][752][753][754] 1996) criteria to determine level of evidence, followed by a guideline determination of one of the following: recommendation, suggestion, or no guideline possible, using Somerfield's (Classic Pap Cur Comments 4:881-886, 2000) schema.Results Fifty-two published papers were examined by treatment population (radiotherapy, chemotherapy, and hematopoietic stem cell transplant) and by whether the intervention aimed to prevent or treat OM. The resulting practice suggestions included using oral care protocols for preventing OM across all treatment modalities and age groups and not using chlorhexidine mouthwash for preventing OM in adults with head and neck cancer undergoing radiotherapy. Considering inadequate and/or conflicting evidence, no guidelines for prevention or treatment of OM were possible for the interventions of dental care, normal saline, sodium bicarbonate, mixed medication mouthwash, chlorhexidine in patients receiving chemotherapy or hematopoietic stem cell transplant, or calcium phosphate. Conclusions The evidence for basic oral care interventions supports the use of oral care protocols in patient populations receiving radiation and/or chemotherapy and does not support chlorhexidine for prevention of mucositis in head and neck cancer patients receiving radiotherapy. Additional welldesigned research is needed for other interventions to improve the amount and quality of evidence guiding future clinical care.

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Section: Methodsmentioning

confidence: 99%

Systematic review of basic oral care for the management of oral mucositis in cancer patients

McGuire

Fulton²,

Park

et al. 2013

Support Care Cancer

219

151

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“…[23][24][25] The incidence of oral mucositis (WHO grades I-IV) in dose-intensified treatment settings has been reported in up to 90% with a range of severe mucositis (WHO grade III/IV) from 10% to 78%. 7,17,[24][25][26][27][28][29][30][31] Severe oral mucositis can be accentuated in patients treated with concomitant chemo-radiotherapy for head and neck cancer. In addition, susceptibility to cytotoxic drugs differs between different mucosal tissues ( Table 1).…”

Section: Incidence and Etiology Of Oral Mucositismentioning

confidence: 99%

Prophylaxis and treatment of chemo- and radiotherapy-induced oral mucositis – are there new strategies?

Karthaus

Rosenthal

Ganser

1999

Bone Marrow Transplant

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Summary:Oral mucositis is a major dose-limiting toxic effect of intensive cancer chemotherapy. Oral complications may lead to dose reduction or delay in further cancer treatment. Mucositis can be caused directly by cytotoxic effects and indirectly by sustained neutropenia after cytostatic therapy. An impaired mucosal barrier predisposes to life-threatening septic complications during aplasia. The prevalence of an oral focus in febrile neutropenia has been reported in up to 30% of cases and also reduces quality of life. The basic strategies aim at pain relief and prevention of bacterial and fungal infectious complications. However, no effective causal prophylaxis or treatment of oral mucositis is widely accepted. The introduction of cytokines, eg granulocytemacrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) for oral mucositis may be particularly effective and offer a new and hopeful approach. At present, the optimal growth factor, best schedule, effective dosage and best mode of application is not known.

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“…Granulokine® (Filgrastim G-CSF), a human granulocyte colony stimulating factor whose action over the bone marrow increases the production and mobilization of neutrophils, did not present a significant statistical difference reducing the mucositis seriousness (15)(16)(17)(18) . A study which compared the intensive oral hygiene regime (IOH) with limited oral hygiene (LOH) did not present significant statistical difference (19) . It is relevant highlighting that the IOH included a complete exam of the mouth, in order to detect and treat cavities, periodontal lesions, periapical disease, mispositioned teeth, and assess dental prostheses adequacy, while the LOH excluded the preventive treatment, as well as teeth and gums brushing.…”

Section: Resultsmentioning

confidence: 99%

Tratamento da mucosite em pacientes submetidos a transplante de medula óssea: uma revisão sistemática

Ferreira¹,

Gamba

Saconato

et al. 2011

Acta paul. enferm.

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Objective: To identify therapeutic measures to reduce the severity of oral mucositis in adult patients undergoing bone marrow transplantation (BMT). Methods: A systematic review using the following databases: LILACS, MEDLINE, CINAHL, EMBASE, CENTRAL (Cochrane Central) and DARE (Database of abstracts of reviews of effects), for the period between 1972 to July 2010, using the key words mucositis, stomatitis and bone marrow transplantation. Results: We identified 3,839 abstracts, 22 of which were included in the systematic review; these articles identified 14 topical and systemic interventions, among which eight showed statistical significance for the reduction of this complication. The topical therapies were: cryotherapy, chlorhexidine, glutamine, laser and Traumeel ®. The systemic therapies were: amifostine, Granulokine ®, and palifermin. Conclusion: The heterogeneity of the results of these interventions and the lack of better elucidation for healthcare practice indicate the need for more accurate research to identify the effectiveness of topical therapies for repair of mucosal cells.

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Prevention of oral mucositis in patients treated with high-dose chemotherapy and bone marrow transplantation: A randomised controlled trial comparing two protocols of dental care

Cited by 161 publications

References 15 publications

Systematic review of basic oral care for the management of oral mucositis in cancer patients

Systematic review of basic oral care for the management of oral mucositis in cancer patients

Prophylaxis and treatment of chemo- and radiotherapy-induced oral mucositis – are there new strategies?

Tratamento da mucosite em pacientes submetidos a transplante de medula óssea: uma revisão sistemática

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