Prevention of Orthopedic Device-Associated Osteomyelitis Using Oxacillin-Containing Biomineral-Binding Liposomes

Liu, Xin Ming; Zhang, Yijia; Fu, Changhong; Khutsishvili, Irine; Fehringer, Edward V.; Marky, Luis A.; Bayles, Kenneth W.; Wang, Dong

doi:10.1007/s11095-012-0812-7

Cited by 30 publications

(19 citation statements)

References 41 publications

(41 reference statements)

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“…The BBL pretreated discs showed almost complete biofilm inhibition. [56] Similarly, liposomes that can adhere to the dental surface can prevent caries by sustained release of antimicrobial agents. It was shown that cariogenic Streptococci can deposit insoluble glucans on the dental enamel which provide support for bacterial colonization.…”

Section: Prolonged Contact Time: Treatment and Prevention Of Biofilm mentioning

confidence: 99%

Lipid and polymer nanoparticles for drug delivery to bacterial biofilms

Forier

Raemdonck

Smedt

et al. 2014

Journal of Controlled Release

372

320

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Biofilms are matrix-enclosed communities of bacteria that show increased antibiotic resistance and the capability to evade the immune system. They can cause recalcitrant infections which cannot be cured with classical antibiotic therapy. Drug delivery by lipid or polymer nanoparticles is considered a promising strategy for overcoming biofilm resistance. These particles are able to improve the delivery of antibiotics to the bacterial cells, thereby increasing the efficacy of the treatment. In this review we give an overview of the types of polymer and lipid nanoparticles that have been developed for this purpose. The antimicrobial activity of nanoparticle encapsulated antibiotics compared to the activity of the free antibiotic is discussed in detail. In addition, targeting and triggered drug release strategies to further improve the antimicrobial activity are reviewed. Finally, ample attention is given to advanced microscopy methods that shed light on the behavior of nanoparticles inside biofilms, allowing further optimization of the nanoformulations. Lipid and polymer nanoparticles were found to increase the antimicrobial efficacy in many cases. Strategies such as the use of fusogenic liposomes, targeting of the nanoparticles and triggered release of the antimicrobial agent ensured the delivery of the antimicrobial agent in close proximity of the bacterial cells, maximizing the exposure of the biofilm to the antimicrobial agent. The majority of the discussed papers still present data on the in vitro anti-biofilm activity of nanoformulations, indicating that there is an urgent need for more in vivo studies in this field.

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Section: Prolonged Contact Time: Treatment and Prevention Of Biofilm mentioning

confidence: 99%

Lipid and polymer nanoparticles for drug delivery to bacterial biofilms

Forier

Raemdonck

Smedt

et al. 2014

Journal of Controlled Release

372

320

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“…Liposomes, phospholipid bilayer vesicles, confer antiadhesive properties to abiotic surfaces (7,14,15) and concentrate the antimicrobial pay load at the device surface and biofilm interfaces (15,20). In addition, liposomes can be designed to fuse with microbial cell membrane, enhancing antimicrobial efficacy (21) and to bind with the device-related infection site (22). Similar to liposomes, niosomes are bilayer hydrated vesicles of non-ionic surfactants and cholesterol (23).…”

Section: Introductionmentioning

confidence: 99%

Vancomycin-Eluting Niosomes: A New Approach to the Inhibition of Staphylococcal Biofilm on Abiotic Surfaces

et al. 2014

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Abstract. A new vancomycin (VCM)-eluting mixed bilayer niosome formulation was evaluated for the control of staphylococcal colonization and biofilm formation on abiotic surfaces, a niosome application not explored to date. Cosurfactant niosomes were prepared using a Span 60/Tween 40/cholesterol blend (1: 1: 2). Tween 40, a polyethoxylated amphiphile, was included to enhance VCM entrapment and confer niosomal surface properties precluding bacterial adhesion. VCM-eluting niosomes showed good quality attributes including relatively high entrapment efficiency (∼50%), association of Tween 40 with vesicles in a constant proportion (∼87%), biphasic release profile suitable for inhibiting early bacterial colonization, and long-term stability at 4°C for a 12-month study period. Niosomes significantly enhanced VCM activity against planktonic bacteria of nine staphylococcal strains. Using microtiter plates as abiotic surface, VCM-eluting niosomes proved superior to VCM in inhibiting biofilm formation, eradicating surface-borne biofilms, inhibiting biofilm growth, and interfering with biofilm induction by VCM subminimal inhibitory concentrations. Data suggest dual functionality of cosurfactant VCM-eluting niosomes as passive colonization inhibiting barrier and active antimicrobial-controlled delivery system, two functions recognized in infection control of abiotic surfaces and medical devices.

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“…These systems may be administered intravenously but they may also be incorporated into nonbiodegradable (i.e., poly(methyl methacrylate) -PMMA) and biodegradable (i.e., calcium sulphate and phosphate) bone cements for local delivery to the bone (Table 1). Regarding the formulations intended for intravenous administration, oxacilin-loaded biomineral-binding liposomes are a promising strategy for targeted antibiotic delivery to the bone [19]. Due to their high affinity to hydroxyapatite (HA), which resembles the chemical composition of bone and therefore is the main component of calcium phosphate bone cements, these liposomes are able to accumulate on the surface of HA implants thus increasing the local antibiotic concentrations.…”

Section: Lipid Nanoparticlesmentioning

confidence: 99%

“…However, HA as well as other calcium-based biomaterials have also been used as coatings for stainless steel and titanium implants in order to enhance their biocompatibility and reduce 10 Oxacillin-containing biomineral-binding liposomes showed stronger in vitro inhibition of biofilm formation on hydroxyapatite (HA) discs, compared with the nonbinding formulation and free drug [19] Lecithin, stearylamine and cholesterol (cationic liposomes); lecithin, La-phosphatidyl-DL-glycerol and cholesterol (anionic liposomes); and lecithin and cholesterol (neutral liposomes)…”

Section: Calcium-based Nanoparticlesmentioning

confidence: 99%

Nanoparticulate Platforms for Targeting Bone Infections: Meeting a Major Therapeutic Challenge

Ferreira

Bettencourt

Almeida

2015

Nanomedicine (Lond.)

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Bone infections are devastating complications in orthopedics due to biofilm formation. Treatment requires high antibiotic doses, which may lead to systemic toxicity thus limiting the drug therapeutic effectiveness. In this context, nanoparticles are well-known controlled release drug carriers that are able to modulate release rate, versatile in terms of administration routes and may be used as local delivery systems. Regarding bone infections, although nanoparticles are a promising strategy for overcoming biofilm tolerance, there are clearly technical, safety, regulatory and clinical challenges that need to be overcome before such nanomedicines may be translated into clinical use. In this paper, we present a critical overview on the high expectations against the real potential of the nanotechnological approaches to bone infection treatment.

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Prevention of Orthopedic Device-Associated Osteomyelitis Using Oxacillin-Containing Biomineral-Binding Liposomes

Cited by 30 publications

References 41 publications

Lipid and polymer nanoparticles for drug delivery to bacterial biofilms

Lipid and polymer nanoparticles for drug delivery to bacterial biofilms

Vancomycin-Eluting Niosomes: A New Approach to the Inhibition of Staphylococcal Biofilm on Abiotic Surfaces

Nanoparticulate Platforms for Targeting Bone Infections: Meeting a Major Therapeutic Challenge

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