Prevention of peritendinous adhesions with electrospun polyethylene glycol/polycaprolactone nanofibrous membranes

Chen, Chih‐Hao; Chen, Shih-Hsien; Shalumon, K.T.; Chen, Jyh‐Ping

doi:10.1016/j.colsurfb.2015.06.012

Cited by 62 publications

(53 citation statements)

References 42 publications

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“…Clearly, the introduction of PCD significantly weakened the elongation at break but prominently increased the ultimate tensile strengths of present composite fibers. This change phenomena seemed similar to previous report about electrospun composite poly(ethylene glycol)/poly(caprolactone) nanofibrous membrane [67]. One explanation could be that the content of PCD increased with the decrease of solvents, resulting in the presence of hard segments or clusters.…”

Section: Resultssupporting

confidence: 90%

Fabrication and Highly Efficient Dye Removal Characterization of Beta-Cyclodextrin-Based Composite Polymer Fibers by Electrospinning

et al. 2019

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Dye wastewater is one of the most important problems to be faced and solved in wastewater treatment. However, the treatment cannot be single and simple adsorption due to the complexity of dye species. In this work, we prepared novel composite fiber adsorbent materials consisting of ε-polycaprolactone (PCL) and beta-cyclodextrin-based polymer (PCD) by electrospinning. The morphological and spectral characterization demonstrated the successful preparation of a series of composite fibers with different mass ratios. The obtained fiber materials have demonstrated remarkable selective adsorption for MB and 4-aminoazobenzene solutions. The addition of a PCD component in composite fibers enhanced the mechanical strength of membranes and changed the adsorption uptake due to the cavity molecular structure via host–guest interaction. The dye removal efficiency could reach 24.1 mg/g towards 4-aminoazobenzene. Due to the admirable stability and selectivity adsorption process, the present prepared beta-cyclodextrin-based composite fibers have demonstrated potential large-scale applications in dye uptake and wastewater treatment.

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Section: Resultssupporting

confidence: 90%

Fabrication and Highly Efficient Dye Removal Characterization of Beta-Cyclodextrin-Based Composite Polymer Fibers by Electrospinning

et al. 2019

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“…A conceptual combination of hyaluronan acid and a silver scaffold, however, could also bear some benefits but also bear some problems as a recent article suggested [ 32 ]: Peritendinous adhesions, one of the common complications after tendon injury and subsequent surgery has led to the interesting development and investigation on a physical barrier between the injured site and the surrounding tissue using silver (Ag) nanoparticles embedded in electrospun hyaluronan acid (HA)/polycaprolactone (PCL) nanofibrous scaffolds (NFMs) (HA/PCL + Ag NFMs) to prevent peritendinous adhesions and bacterial infection after tendon surgery. This in vitro cell culture experiments revealed that HA/PCL + Ag NFMs exhibited the highest inhibition of fibroblast attachment and proliferation.…”

Section: Discussionmentioning

confidence: 99%

Response of human dental pulp cells to a silver-containing PLGA/TCP-nanofabric as a potential antibacterial regenerative pulp-capping material

et al. 2017

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BackgroundDamage or exposure of the dental pulp requires immediate therapeutic intervention.MethodsThis study assessed the biocompatibility of a silver-containing PLGA/TCP-nanofabric scaffold (PLGA/Ag-TCP) in two in vitro models, i.e. the material adapted on pre-cultured cells and cells directly cultured on the material, respectively. Collagen saffolds with and without hyaluronan acid (Coll-HA; Coll) using both cell culturing methods and cells growing on culture plates served as reference. Cell viability and proliferation were assessed after 24, 48, and 72 h based on formazan formation and BrdU incorporation. Scaffolds were harvested. Gene expression of interleukin(IL)-6, tumor necrosis factor (TNF)-alpha, and alkaline phosphatase (AP) was assessed 24 h after stimulation.ResultsIn both models formazan formation and BrdU incorporation was reduced by PLGA/Ag-TCP on dental pulp cells, while no significant reduction was found in cells with Coll and Coll-HA. Cells with PLGA/Ag-TCP for 72 h showed similar relative BrdU incorporation than cells stimulated with Coll and Coll-HA. A prominent increase in the pro-inflammatory genes IL-6 and TNF-α was observed when cells were cultured with PLGA/Ag-TCP compared to the other groups. This increase was parallel with a slight increase in AP expression. Overall, no differences between the two culture methods were observed.ConclusionsPLGA/Ag-TCP decreased viability and proliferation rate of human dental pulp cells and increased the pro-inflammatory capacity and alkaline phosphatase expression. Whether these cellular responses observed in vitro translate into pulp regeneration in vivo will be assessed in further studies.

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“…To test the cell barrier function of these nanofibrous membrane, we evaluated the effects of the novel membranes on cell migration using a fibroblast cell line (L929 cell) according to a previous published paper 17) . The cells were cultured in MEM containing 2 or 10% FBS in a double chamber dish divided by a porous membrane (Transwell cell culture inserts, Corning, NY, USA).…”

Section: Cell Barrier Function Testing For Nanofibrous Membranementioning

confidence: 99%

Osteogenic induction of bone marrow mesenchymal cells on electrospun polycaprolactone/chitosan nanofibrous membrane

Wang

Tang

et al. 2017

Dental Materials Journal

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A novel chitosan/polycaprolactone (CS/PCL) nanofibrous membrane by electrospinning was developed for guided tissue regeneration (GTR) to improve mechanical properties and to promote osteogenic differentiation. Firstly, chitosan and PCL solutions of different weight ratios (0/100, 30/70, 50/50) were mixed and then electrospun. Our data demonstrated that the CS/PCL (30/70) nanofibrous membrane promoted an increased rBMSCs proliferation when compared to the CS/PCL (50/50) membrane and pure PCL (0/100) membrane. The highest ALP activity and extracellular calcium deposit were observed on the CS/PCL (30/70) nanofibrous membrane, followed by the CS/PCL (50/50) and pure PCL nanofibrous membrane. Furthermore, the expression of osteocalcin (OCN) and Runx2 were also significantly higher on the CS/PCL (30/70, 50/50) nanofibrous membrane as compared to the pure PCL nanofibrous membrane. In conclusion, the electrospun CS/PCL nanofibrous membrane was found to be a biocompatible material that could stimulate osteogenic differentiation, suggesting that the novel CS/PCL membrane has an interesting potential as use for GTR.

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Prevention of peritendinous adhesions with electrospun polyethylene glycol/polycaprolactone nanofibrous membranes

Cited by 62 publications

References 42 publications

Fabrication and Highly Efficient Dye Removal Characterization of Beta-Cyclodextrin-Based Composite Polymer Fibers by Electrospinning

Fabrication and Highly Efficient Dye Removal Characterization of Beta-Cyclodextrin-Based Composite Polymer Fibers by Electrospinning

Response of human dental pulp cells to a silver-containing PLGA/TCP-nanofabric as a potential antibacterial regenerative pulp-capping material

Osteogenic induction of bone marrow mesenchymal cells on electrospun polycaprolactone/chitosan nanofibrous membrane

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