Prevention of Postoperative Nausea and Vomiting With Antiemetics in Patients Undergoing Middle Ear Surgery

Fujii, Yoshitaka; Tanaka, Hiroyoshi; Kimura, Noriaki

doi:10.1001/archotol.127.1.25

Cited by 21 publications

(9 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our study coincides with the findings of various studies of Fuji et al [6,7,[10][11][12] where complete response rate were between 78 and 86% with varying doses of granisetron having the PONV 14-22%. PONV was much less in our study although we had used granisetron in lesser dose as compared to these studies.…”

Section: Discussionsupporting

confidence: 92%

Randomized Double Blind Comparative Study Comparing Efficacy of Granisetron and Ondansetron for the Prophylactic Control of Postoperative Nausea and Vomiting in Patients Undergoing Middle Ear Surgery

Dua

Sethi

Sood

et al. 2012

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

The objective is to evaluate the prophylactic profile, efficacy of granisetron and ondansetron to prevent postoperative nausea and vomiting (PONV) after middle ear surgery. In a randomized, double blind trial, one hundred patients undergoing middle ear surgery received either granisetron 1 mg or ondansetron 8 mg in equal volume (n = 50 for each) intravenously towards the end of surgery and before reversal of anaesthesia. A standard general anaesthetic technique was employed. Postoperatively, during the first 24 h after anaesthesia, the incidence of PONV, recovery score, time to first feeding, willingness to have the same prophylactic antiemetic drug in future and adverse events were recorded. The incidence of vomiting once (PONV score 2) was significantly less, 4% with granisetron and 22% with ondansetron (P = 0.002) respectively and the incidence of vomiting twice or more times in 30 min interval (PONV score 3) was significantly less, 8% with granisetron as compared to 34% with ondansetron (P = 0.001). The requirement of rescue antiemetic drug was significantly higher in ondansetron group, i.e. 34 vs. 8% in granisetron group (P = 0.001). The incidence of adverse events, recovery score and time to first feeding were comparable among the groups. Willingness to have the same prophylactic antiemetic drug in future was significantly high in patients receiving granisetron. Granisetron is more efficacious and desirable drug than ondansetron for reducing the incidence of PONV in patients undergoing middle ear surgery.

show abstract

Section: Discussionsupporting

confidence: 92%

Randomized Double Blind Comparative Study Comparing Efficacy of Granisetron and Ondansetron for the Prophylactic Control of Postoperative Nausea and Vomiting in Patients Undergoing Middle Ear Surgery

Dua

Sethi

Sood

et al. 2012

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

“… 5,6 No data were available regarding the dose of ramosetron to be used in children, but the single dose of ramosetron used in this study was extrapolated from an investigation in adults. 8 …”

Section: Methodsmentioning

confidence: 99%

“…7 We have recently demonstrated that prophylactic therapy with ramosetron is more effective than granisetron for the prevention of postoperative nausea and vomiting within a 48‐hour period after anesthesia in patients undergoing middle ear surgery. 8 However, there have been no reports comparing the antiemetic efficacy of ramosetron with granisetron in children at high risk of vomiting after tonsillectomy. We designed this prospective, randomized, double‐blinded study to compare the efficacy and safety of granisetron and ramosetron for the prevention of vomiting after pediatric tonsillectomy.…”

Section: Introductionmentioning

confidence: 99%

Prevention of Vomiting After Tonsillectomy in Children: Granisetron Versus Ramosetron

Fujii¹,

Saitoh²,

Kimura³

2001

The Laryngoscope

Self Cite

View full text Add to dashboard Cite

show abstract

“…(23) Propofol also resulted in less PONV than sevoflurane (24) and was better than droperidol and metoclopramide. (72)(73) Pretreatment with oral clonidine enhances the antiemetic effect of propofol, preventing postoperative vomiting. (74) It has been reported that CP-122,721, a neurokinin-1 antagonist, at a dose of 200 mg orally before induction of anesthesia resulted in decreased emetic episodes compared to ondansetron.…”

Section: Treatmentmentioning

confidence: 99%

Postoperative Nausea and Vomiting: Cause, Prevention, and Treatment

Shiffman¹

2003

International Journal of Cosmetic Surgery and Aesthetic Dermato

View full text Add to dashboard Cite

Postoperative nausea and vomiting (PONV) occur in an average of 20-40% of patients. There are many drugs and combinations of drugs for the prevention and treatment of PONV. Prophylactic antiemetics should be considered in the high-risk patient (prior history of motion sickness, past history of PONV, certain surgical procedures such as strabismus surgery and middle ear surgery). Avoid perioperative opioids, which are known to cause PONV, when possible by substituting a drug such as Stadol. Female nonsmokers have a higher risk for PONV than other groups, but there probably would not be an indication to use prophylactic agents in such patients unless another risk factor is also present. 87

show abstract

Prevention of Postoperative Nausea and Vomiting With Antiemetics in Patients Undergoing Middle Ear Surgery

Abstract: A small dose of propofol is a better antiemetic than droperidol or metoclopramide for the prevention of postoperative nausea and vomiting after middle ear surgery.

Cited by 21 publications

References 15 publications

Randomized Double Blind Comparative Study Comparing Efficacy of Granisetron and Ondansetron for the Prophylactic Control of Postoperative Nausea and Vomiting in Patients Undergoing Middle Ear Surgery

Randomized Double Blind Comparative Study Comparing Efficacy of Granisetron and Ondansetron for the Prophylactic Control of Postoperative Nausea and Vomiting in Patients Undergoing Middle Ear Surgery

Prevention of Vomiting After Tonsillectomy in Children: Granisetron Versus Ramosetron

Postoperative Nausea and Vomiting: Cause, Prevention, and Treatment

Contact Info

Product

Resources

About