Prevention of postoperative nausea and vomiting with a subhypnotic dose of Propofol in patients undergoing lower abdominal surgery: A prospective, randomized, double-blind study

Abstract

Background:Postoperative nausea and vomiting (PONV) is a common complication after general anesthesia in patients undergoing elective lower abdominal surgery. We aimed to compare the effect of a sub hypnotic dose of Propofol in the prevention of PONV after lower abdominal surgery with that of the conventional antiemetic drug Metoclopramide.Materials and Methods:In this prospective, randomized, double-blind, placebo-controlled study, 104 patients with American Society of Anesthesiologists (ASA) class I or II status, aged 18–65 years, and undergoing elective lower abdominal surgery were randomized to one of four groups (n = 26 each). The patients in the four groups were administered intravenously Propofol 20 mg (G1), Propofol 30 mg (G2), Metoclopramide 10 mg (G3), and placebo (G4), 15 min before skin closure. All episodes of PONV during the first 24 h after anesthesia were recorded by an investigator who was blinded to treatment assignment.Results:There were no significant differences between the treatment groups with regard to their gender, age, ASA class, duration of surgery, duration of recovery time and hospital stay, and also body mass index (BMI) (P > 0.05). The prevalence of PONV 0-6 h after anesthesia was 23.08% with Propofol 20 mg (P = 0.005), 15.38% with Propofol 30 mg (P = 0.016), 15.38% with Metoclopramide 10 mg (P = 0.016), compared to 30.77% with placebo (P = 0.005).Conclusions:Administration of a subhypnotic dose of Propofol (30 mg) was found to be as effective as 10 mg Metoclopramide in reducing the incidence and severity of PONV in adult patients undergoing elective lower abdominal surgeries under Isoflurane-based anesthesia in the early postoperative period.

Incidence of nausea/vomiting following propofol sedation with adaptive servo‐ventilation for atrial fibrillation ablation

“…As noted above, propofol has been recognized for its antiemetic effects 26 . The administration of sub‐hypnotic doses of propofol has been reported to reduce PONV in parturients undergoing cesarean section and in patients undergoing abdominal surgery 27 . Notably, these previous studies administered propofol just before the end of surgery.…”

“…26 The administration of sub-hypnotic doses of propofol has been to reduce PONV in parturients undergoing cesarean section and in patients undergoing abdominal surgery. 27 Notably, these previous studies administered propofol just before the end of surgery. In contrast, propofol was administered continuously during the AF ablation procedure in our study, and the propofol dosage was adjusted to maintain a sedation level of 6 on the Ramsay sedation scale.…”

Clasificación y tratamiento de náusea y vómito postoperatorio en el paciente oncológico sometido a cirugía

“…Actualmente, son un fármaco de segunda o tercera línea para la profilaxis y tratamiento de (NVPO). La escopolamina transdérmica es un anticolinérgico que sería útil para prevenir las (NVPO) como coadyuvante de otras terapias antieméticas, administrada el día previo a la cirugía o 2 h previas al inicio de la anestesia [31].…”