Prevention of Prosthetic Joint Infection: From Traditional Approaches towards Quality Improvement and Data Mining

Gallo, Jiří; Nieslanikova, Eva

doi:10.3390/jcm9072190

Cited by 20 publications

(13 citation statements)

References 221 publications

(218 reference statements)

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“…al recommended the nutritional status of patients be evaluated before joint replacement surgery, including indicators such as serum albumin level, lymphocyte count, and transferrin level (17). During the operation, strict disinfection should be performed on the skin of the surgical area (18,19), and the addition of disinfection records can also reduce the risk of infection (20,21). There are many studies on the use of antibiotics for preventive treatment during the perioperative period, but the optimal plan requires further study.…”

Section: Discussionmentioning

confidence: 99%

Periprosthetic joint infection after total knee arthroplasty: a bibliometrics analysis

Shen¹,

Zhang²,

Zhang³

et al. 2021

Ann Palliat Med

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Background: Total knee arthroplasty (TKA) has brought hope to patients with malignant knee joint diseases. Infection is one of the serious complications after TKA, and the purpose of this study was to use bibliometrics to analyze the current research status of infection after this surgery, to unmask any deficiencies with current research, and to provide references for future researchers.Methods: We used the Science Citation Index Expanded (SCI-E) database in the Web of Science Core Collection (WOSCC) as the data source, using the search terms "total knee arthroplasty" and "infection" respectively. The "And" operation was performed on the search results of the two subject terms, and the intersection of the two search results was taken as the final search result. CiteSpace software was used to analyze the results. Results:The search results consisted of 5,600 documents, with a total citation frequency of 148,871. The average number of citations for each literature was 26.58, and the h-index was 142. The top five countries in the number of publications were the United States, China, Germany, the United Kingdom, and Spain, while the top five centrally ranked countries were the United States, the Netherlands, Germany, the United Kingdom, and France. The top five institutions with the number of publications were

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Section: Discussionmentioning

confidence: 99%

Periprosthetic joint infection after total knee arthroplasty: a bibliometrics analysis

Shen¹,

Zhang²,

Zhang³

et al. 2021

Ann Palliat Med

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“…Hematogenous spread of organisms from distant sources of infection can rarely cause SSI by attachment to the prosthesis or other implant left in the operative site. The infection prevention and control practices of SSI are therefore aimed at minimizing the number of pathogens at surgical site [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Bacterial profile and antimicrobial susceptibility patterns of isolates among patients diagnosed with surgical site infection at a tertiary teaching hospital in Ethiopia: a prospective cohort study

Misha¹,

Chelkeba

Melaku

2021

Ann Clin Microbiol Antimicrob

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Background Globally, surgical site infections are the most reported healthcare-associated infection and common surgical complication. In developing countries such as Ethiopia, there is a paucity of published reports on the microbiologic profile and resistance patterns of an isolates. Objective This study aimed at assessing the bacterial profile and antimicrobial susceptibility patterns of isolates among patients diagnosed with surgical site infection at Jimma Medical Center in Ethiopia. Methods A prospective cohort study was employed among adult patients who underwent either elective or emergency surgical procedures. All the eligible patients were followed for 30 days for the occurrence of surgical site infection (SSI). From those who developed SSI, infected wound specimens were collected and studied bacteriologically. Results Of 251 study participants, 126 (50.2%) of them were females. The mean ± SD age of the patients was 38 ± 16.30 years. The overall postoperative surgical site infection rate was 21.1% and of these 71.7% (38/53) were culture positive. On gram stain analysis, 78% of them were Gram-negative, 11.5% were Gram-positive and 10.5% were a mixture of two microbial growths. Escherichia coli accounted for (21.43%), followed by Pseudomonas aeruginosa (19.05%), Proteus species (spp.) 14.29%), Staphylococcus aureus (11.90%), Klebsiella species (11.90%), Citrobacter spp. (9.5%), streptococcal spp. (7.14%), Coagulase-negative S. aureus (CoNS) (2.38%) Conclusion Gram-negative bacteria were the most dominant isolates from surgical sites in the study area. Among the Gram-negative bacilli, Escherichia coli were the most common bacteria causing surgical site infection. As there is high antibiotic resistance observed in the current study, it is necessary for routine microbial analysis of samples and their antibiogram.

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“…More complex PJIs preventative measures have been progressively applied in clinical practice, including perioperative and postoperative strategies [18]. However, in some cases, infection develops and current treatment includes antibiotherapy, which relies on systemic administration of a combination of antibiotics, such as rifampicin, daptomycin, fluoroquinolones, vancomycin, or amikacin [19].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Peptides in the Battle against Orthopedic Implant-Related Infections: A Review

et al. 2021

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Prevention of orthopedic implant-related infections is a major medical challenge, particularly due to the involvement of biofilm-encased and multidrug-resistant bacteria. Current therapies, based on antibiotic administration, have proven to be insufficient, and infection prevalence may rise due to the dissemination of antibiotic resistance. Antimicrobial peptides (AMPs) have attracted attention as promising substitutes of conventional antibiotics, owing to their broad-spectrum of activity, high efficacy at very low concentrations, and, importantly, low propensity for inducing resistance. The aim of this review is to offer an updated perspective of the development of AMPs-based preventive strategies for orthopedic and dental implant-related infections. In this regard, two major research strategies are herein addressed, namely (i) AMP-releasing systems from titanium-modified surfaces and from bone cements or beads; and (ii) AMP immobilization strategies used to graft AMPs onto titanium or other model surfaces with potential translation as coatings. In overview, releasing strategies have evolved to guarantee higher loadings, prolonged and targeted delivery periods upon infection. In addition, avant-garde self-assembling strategies or polymer brushes allowed higher immobilized peptide surface densities, overcoming bioavailability issues. Future research efforts should focus on the regulatory demands for pre-clinical and clinical validation towards clinical translation.

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Prevention of Prosthetic Joint Infection: From Traditional Approaches towards Quality Improvement and Data Mining

Cited by 20 publications

References 221 publications

Periprosthetic joint infection after total knee arthroplasty: a bibliometrics analysis

Periprosthetic joint infection after total knee arthroplasty: a bibliometrics analysis

Bacterial profile and antimicrobial susceptibility patterns of isolates among patients diagnosed with surgical site infection at a tertiary teaching hospital in Ethiopia: a prospective cohort study

Antimicrobial Peptides in the Battle against Orthopedic Implant-Related Infections: A Review

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